Zobrazeno 1 - 10
of 195
pro vyhledávání: '"K, Jonsdottir"'
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. H
Externí odkaz:
https://doaj.org/article/ff89181888414cdebed058704ff392b1
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/36bf3afec36e4aac961dcc7fb75d1e5e
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Autor:
Claudia B. G. Barnes, Madeline G. Dans, Thorey K. Jonsdottir, Brendan S. Crabb, Paul R. Gilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+ homeostasis in malaria parasites and has been implicated in the mechanism of action of many structurally diverse antimalarial agents, including >7% of the antimalarial compo
Externí odkaz:
https://doaj.org/article/08cdd3cfaeed4e469e4110a4b51aef51
Autor:
Unnur D. Teitsdottir, Taher Darreh-Shori, Sigrun H. Lund, Maria K. Jonsdottir, Jon Snaedal, Petur H. Petersen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundCholinergic drugs are the most commonly used drugs for the treatment of Alzheimer’s disease (AD). Therefore, a better understanding of the cholinergic system and its relation to both AD-related biomarkers and cognitive functions is of hig
Externí odkaz:
https://doaj.org/article/b0c2d4ff77d7468baf3255263f5fea5f
Autor:
Unnur D. Teitsdottir, Maria K. Jonsdottir, Sigrun H. Lund, Taher Darreh-Shori, Jon Snaedal, Petur H. Petersen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2020)
Abstract Background Neuroinflammation has gained increasing attention as a potential contributing factor in the onset and progression of Alzheimer’s disease (AD). The objective of this study was to examine the association of selected cerebrospinal
Externí odkaz:
https://doaj.org/article/e8fabdb2be5d4280a3456fea0bd2b61c
Autor:
Mikha Gabriela, Kathryn M Matthews, Cas Boshoven, Betty Kouskousis, Thorey K Jonsdottir, Hayley E Bullen, Joyanta Modak, David L Steer, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1009977 (2022)
Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of those
Externí odkaz:
https://doaj.org/article/255e629500da4e7bab4f1622c9b59485
Autor:
Hrafnhildur Eymundsdottir, Alfons Ramel, Olof G. Geirsdottir, Sigrun S. Skuladottir, Larus S. Gudmundsson, Palmi V. Jonsson, Vilmundur Gudnason, Lenore Launer, Maria K. Jonsdottir, Milan Chang
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction We aim to investigate the longitudinal associations between changes in body weight (BW) and declines in cognitive function and risk of mild cognitive impairment (MCI)/dementia among cognitively normal individuals 65 years or old
Externí odkaz:
https://doaj.org/article/068db37f76864c8083e67193007d5add
Autor:
Hayley E. Bullen, Paul R. Sanders, Madeline G. Dans, Thorey K. Jonsdottir, David T. Riglar, Oliver Looker, Catherine S. Palmer, Betty Kouskousis, Sarah C. Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo‐Anne Chan, Tania F. de Koning‐Ward, Jake Baum, James W. Kazura, James G. Beeson, Alan F. Cowman, Paul R. Gilson, Brendan S. Crabb
Publikováno v:
Molecular Microbiology. 117:1245-1262
Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite's success is their ability to invade and subsequently grow within human erythrocytes. Parasite proteins involved in para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e333ce452776bb3cf5ddf9a8f4b7c1
https://doi.org/10.1111/mmi.14904
https://doi.org/10.1111/mmi.14904
Creativity, leisure activities, social engagement and cognitive impairment: the AGES-Reykjavík study
Autor:
Helga Hansdottir, María K. Jonsdottir, Diana E. Fisher, Gudny Eiriksdottir, Palmi V. Jonsson, Vilmundur Gudnason
Publikováno v:
Aging Clinical and Experimental Research. 34:1027-1035
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::138d388bfc815a85d643d09323765e11
https://doi.org/10.1007/s40520-021-02036-1
https://doi.org/10.1007/s40520-021-02036-1