Zobrazeno 1 - 10
of 357
pro vyhledávání: '"K, Hock"'
Autor:
Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom, Karen H. Vousden
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion
Externí odkaz:
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
Autor:
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT The indiscriminate use and overuse of various antibiotics have caused the rapid emergence of antibiotic-resistant bacteria (ARB) in poultry products and the surrounding environment, giving rise to global public health issues. This study aime
Externí odkaz:
https://doaj.org/article/d5dee49440a44215bbed35faa83b2da0
Autor:
Helge M. Magnussen, Syed F. Ahmed, Gary. J. Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden, Allan M. Weissman, Danny T. Huang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
p53 is an important tumor suppressor protein which is regulated by the E3 ubiquitin ligase MDM2. Here the authors reveal that DNA damage-induced Ser429 phosphorylation of MDM2 serve to boost the activity of MDM2 homodimer by stabilizing the active E2
Externí odkaz:
https://doaj.org/article/80e8bf383dda460bb88d16b6b1cd6555
Autor:
Julianna Blagih, Fabio Zani, Probir Chakravarty, Marc Hennequart, Steven Pilley, Sebastijan Hobor, Andreas K. Hock, Josephine B. Walton, Jennifer P. Morton, Eva Gronroos, Susan Mason, Ming Yang, Iain McNeish, Charles Swanton, Karen Blyth, Karen H. Vousden
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 481-496.e6 (2020)
Summary: Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequences of p53 mutation have been studied extensively, the role of p53 in regulating the anti-tumor immune response is still poorly understood. H
Externí odkaz:
https://doaj.org/article/9e8f02a81ba8423a9ff553a069bb7e18
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Background In response to oncogenic stress, the tumour suppressor protein p53 can induce the elimination of cells through induction of cell death or senescence, helping to restrain malignant progression. Conversely, under nutrient stress, p5
Externí odkaz:
https://doaj.org/article/7c35c7f3fc3e4313a228b2be6844b89a
Autor:
Andreas K. Hock, Eric C. Cheung, Timothy J. Humpton, Tiziana Monteverde, Viola Paulus-Hock, Pearl Lee, Ewan McGhee, Alessandro Scopelliti, Daniel J. Murphy, Douglas Strathdee, Karen Blyth, Karen H. Vousden
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling with visible light fluorescent proteins such as GFP and RFP suffers from poor tis
Externí odkaz:
https://doaj.org/article/4c0cb0ea555f4d09bb9cec3a0e510cea
Akademický článek
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Akademický článek
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Autor:
Vipin Suri, Mylène Tajan, Owen J. Sansom, Vivian S. W. Li, Rachel A. Ridgway, Laura Novellasdemunt, Eric C. Cheung, Robert L. Ludwig, Marc Hennequart, Nathalie Legrave, Nicola Valeri, Georgios Vlachogiannis, Fabio Zani, Andreas K. Hock, Alejandro Suárez-Bonnet, Nello Mainolfi, Karen Blyth, Mark Manfredi, Adam L. Friedman, Nikolaos Angelis, Karen H. Vousden, Oliver D. K. Maddocks, Dimitris Athineos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f606433f50b018c4e02014a01e9a1511
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
Autor:
Charles Swanton, Marc Hennequart, Sebastijan Hobor, Julianna Blagih, Ming Yang, Susan M. Mason, Steven Pilley, Josephine Walton, Karen H. Vousden, Fabio Zani, Karen Blyth, Jennifer P. Morton, Probir Chakravarty, Andreas K. Hock, Iain A. McNeish, Eva Grönroos
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 481-496.e6 (2020)
196.e6
Cell Reports
196.e6
Cell Reports
Summary Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequences of p53 mutation have been studied extensively, the role of p53 in regulating the anti-tumor immune response is still poorly understood. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739f1f60383121c624cb1664777663b3
http://www.sciencedirect.com/science/article/pii/S221112471931678X
http://www.sciencedirect.com/science/article/pii/S221112471931678X