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Autor:
J.-D. Horisberger, K. Geering
The distribution of Na,K-ATPase isoforms in the nervous system is rather complex, but it can be roughly summarized as follows: α1 isoform is ubiquitous, α2 isoform is mostly expressed in astrocytes, and α3 isoform is generally restricted to neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98dd2f397a83093da783d96b50860d7
https://doi.org/10.1016/b978-008045046-9.01737-x
https://doi.org/10.1016/b978-008045046-9.01737-x
Autor:
K, Geering
Publikováno v:
Journal of bioenergetics and biomembranes. 33(5)
Na,K-ATPase and gastric and nongastric H,K-ATPases are the only P-type ATPases of higher organisms that are oligomeric and are associated with a beta subunit, which is obligatory for expression and function of enzymes. Topogenesis studies suggest tha
Publikováno v:
The Journal of biological chemistry. 275(37)
The structural and molecular determinants that govern the correct membrane insertion and folding of membrane proteins are still ill-defined. By following the addition of sugar chains to engineered glycosylation sites (glycosylation mapping) in Na,K-A
Publikováno v:
Acta physiologica Scandinavica. Supplementum. 643
Na,K-ATPase activity must be finely controlled to meet the constantly changing physiological demands and to avoid destabilization of body homeostasis. Recent experimental evidence suggests that certain regulatory mechanisms are closely linked to the
Publikováno v:
The American journal of physiology. 275(1)
The catalytic alpha-subunit of oligomeric P-type ATPases such as Na-K-ATPase and H-K-ATPase requires association with a beta-subunit after synthesis in the endoplasmic reticulum (ER) to become stably expressed and functionally active. In this study,
Autor:
A T, Beggah, K, Geering
Publikováno v:
Annals of the New York Academy of Sciences. 834
Publikováno v:
Molecular biology of the cell. 8(3)
The effect of protein kinase C (PKC) stimulation on the pump current (Ip) generated by the Na,K-ATPase was measured in A6 epithelia apically permeabilized with amphotericin B. Phorbol 12-myristate 13-acetate (PMA) produced a decrease in Ip carried by
Publikováno v:
The Sodium Pump ISBN: 9783642725135
Assembly of catalytic α-subunits of Na+,K+-ATPase with β-subunits is a prerequisite for the structural and functional maturation of newly synthesized α-subunit and its intracellular transport from the ER to the plasma membrane (2). Little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b9e47a98f99f5329e10f69b832b5c52
https://doi.org/10.1007/978-3-642-72511-1_32
https://doi.org/10.1007/978-3-642-72511-1_32
Publikováno v:
Biochemistry. 32(51)
To define the structural basis of oligomerization for the alpha- and beta-subunits of Na,K-ATPase, we have attempted to identify the amino acids in the C-terminus of the beta-subunit that are involved in subunit assembly. We predicted that the last 1