Zobrazeno 1 - 10
of 313
pro vyhledávání: '"K, Görlitzer"'
Publikováno v:
Die Pharmazie. 62(2)
2,5-Dichloro-4-methyl-benzo[c][2,7]naphthyridine (1) reacted with aromatic amines selectively by substitution at the 5-position to yield the amidines 2. The 4-aminophenol 2c could also be synthesized by cleavage of the ether 2b. The structure of 2c w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3cd54333b59d0772f4bce5dbd0e0f13
https://pubmed.ncbi.nlm.nih.gov/17341024
https://pubmed.ncbi.nlm.nih.gov/17341024
Publikováno v:
Die Pharmazie. 62(1)
The chloroimine 1a reacted with the novaldiamine-base to yield the 5-(2-methylpyrrolidinyl)-derivative 3. The 5-chloro-benzonaphthyridines 1 and 9 reacted with secondary aliphatic amines to give the amidines 5-8 and 10, while the aromatic amidines 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cb81f005a17fd5d02e57a8dd3d9c1fb
https://pubmed.ncbi.nlm.nih.gov/17294807
https://pubmed.ncbi.nlm.nih.gov/17294807
Publikováno v:
Die Pharmazie. 61(12)
The 2,5-dichlorobenzo[c][2,7]naphthyridine 6 was synthesized starting from the 2-pyridone 1 in four or five steps, respectively. The 5-yl amine 7 and the 2,5-diyl amines 8 and 9 were isolated by the reaction of compound 6 with the novaldiamine base.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::319faf910c87686d62a97c0da47a1fc9
https://pubmed.ncbi.nlm.nih.gov/17283651
https://pubmed.ncbi.nlm.nih.gov/17283651
Publikováno v:
Die Pharmazie. 61(11)
The 4-aryl derivative 3, obtained by Suzuki cross coupling of the methyl 4-bromothiophene-3-carboxylate (2) with 2-nitrophenylboronic acid cyclizes under reductive conditions pH-dependant to yield the tricyclic hydroxamic acid 4 or the lactam 5. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc48f1d1c433e05615c75c8ef52ebb9a
https://pubmed.ncbi.nlm.nih.gov/17152980
https://pubmed.ncbi.nlm.nih.gov/17152980
Publikováno v:
Die Pharmazie. 61(7)
The irreversible aromatase inhibitor exemestane (6) reacts with nitromethane and sodium ethanolate to yield the Michael adduct 9. The aldehyde 10 is obtained by Nef reaction of the nitro compound 9 and affords the 1,4-dihydropyridine (DHP) 11 by Hant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c666032e92fb5d9ed94505209a1113f1
https://pubmed.ncbi.nlm.nih.gov/16889062
https://pubmed.ncbi.nlm.nih.gov/16889062
Publikováno v:
Die Pharmazie. 61(3)
The 8,8'-biquinoline-5,5'-diones 2A are formed by the erythroquine and thalleioquine reaction from the 6-methoxyquinolines 1 as model compounds. The red substances 2A react with hydrochloric acid to yield the yellow biquinolinedihydrochlorides 3. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83b35b21a4f944e61944b8d0dd418ee0
https://pubmed.ncbi.nlm.nih.gov/16599256
https://pubmed.ncbi.nlm.nih.gov/16599256
Publikováno v:
Die Pharmazie. 61(1)
The pyridone 1a reacts with POCl3/DMF to yield the title compound 2a. After irradiation of 2a the enolether 3 is isolated, as shown by an X-ray structure determination. The pyridine 4 obtained by dehydrogenation of 2a leads under reductive conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdfcbcd49268be62df6e1abe645ef784
https://pubmed.ncbi.nlm.nih.gov/16454197
https://pubmed.ncbi.nlm.nih.gov/16454197
Publikováno v:
Die Pharmazie. 60(8)
The o-nitrobenzylidene acetoacetic esters 1 dimerize in the presence of BuLi or LDA to give the cyclohexenes 2 in poor yield. Two diastereomer of 2b were isolated, whose configuration is deduced by nmr-spectroscopic methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2168d2557a62c9fcb77522e521aec0d
https://pubmed.ncbi.nlm.nih.gov/16124397
https://pubmed.ncbi.nlm.nih.gov/16124397
Publikováno v:
Die Pharmazie. 60(7)
The reaction of the 1,5-diketones 1 with acetic anhydride/acetic acid in the presence of zinc chloride yields the 4-aryl-4H-pyrans 2 as main products. The annulated lactone 3 and the cyclohexene derivatives 5 are isolated as by-products. The configur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa6e1f1ce84bed26beee41d9f930f489
https://pubmed.ncbi.nlm.nih.gov/16076073
https://pubmed.ncbi.nlm.nih.gov/16076073
Publikováno v:
Die Pharmazie. 60(4)
Colour reaction of chlorhexidine and proguanil with hypobromite The antimalarial agent proguanil reacts with hypobromite to yield the red coloured (E)-3-[(4-chlorophenyl)imino]-N-isopropyl-3H-1,2,4-triazol-5-amine (6B). The structure of 6B was proven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b4f4faa02bfd7220a7694a994fccac1
https://pubmed.ncbi.nlm.nih.gov/15881606
https://pubmed.ncbi.nlm.nih.gov/15881606