Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction

Autor: Esteban M. Lucero, Ronald K. Freund, Alexandra Smith, Noah R. Johnson, Breanna Dooling, Emily Sullivan, Olga Prikhodko, Md. Mahiuddin Ahmed, David A. Bennett, Timothy J. Hohman, Mark L. Dell’Acqua, Heidi J. Chial, Huntington Potter

Publikováno v: iScience, Vol 25, Iss 11, Pp 105288- (2022)

Summary: Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. T

Externí odkaz: https://doaj.org/article/b454f82fd1d14209a2333f435a60d98d

Characterization of 30 $$^{76}$$ 76 Ge enriched Broad Energy Ge detectors for GERDA Phase II

Autor: M. Agostini, A. M. Bakalyarov, E. Andreotti, M. Balata, I. Barabanov, L. Baudis, N. Barros, C. Bauer, E. Bellotti, S. Belogurov, G. Benato, A. Bettini, L. Bezrukov, T. Bode, D. Borowicz, V. Brudanin, R. Brugnera, D. Budjáš, A. Caldwell, C. Cattadori, A. Chernogorov, V. D’Andrea, E. V. Demidova, N. Di Marco, A. Domula, E. Doroshkevich, V. Egorov, R. Falkenstein, K. Freund, A. Gangapshev, A. Garfagnini, C. Gooch, P. Grabmayr, V. Gurentsov, K. Gusev, J. Hakenmüller, A. Hegai, M. Heisel, S. Hemmer, R. Hiller, W. Hofmann, M. Hult, L. V. Inzhechik, J. Janicskó Csáthy, J. Jochum, M. Junker, V. Kazalov, Y. Kermaïdic, T. Kihm, I. V. Kirpichnikov, A. Kirsch, A. Kish, A. Klimenko, R. Kneißl, K. T. Knöpfle, O. Kochetov, V. N. Kornoukhov, V. V. Kuzminov, M. Laubenstein, A. Lazzaro, B. Lehnert, Y. Liao, M. Lindner, I. Lippi, A. Lubashevskiy, B. Lubsandorzhiev, G. Lutter, C. Macolino, B. Majorovits, W. Maneschg, G. Marissens, M. Miloradovic, R. Mingazheva, M. Misiaszek, P. Moseev, I. Nemchenok, K. Panas, L. Pandola, K. Pelczar, A. Pullia, C. Ransom, S. Riboldi, N. Rumyantseva, C. Sada, F. Salamida, M. Salathe, C. Schmitt, B. Schneider, S. Schönert, A.-K. Schütz, O. Schulz, B. Schwingenheuer, O. Selivanenko, E. Shevchik, M. Shirchenko, H. Simgen, A. Smolnikov, L. Stanco, L. Vanhoefer, A. A. Vasenko, A. Veresnikova, K. von Sturm, V. Wagner, A. Wegmann, T. Wester, C. Wiesinger, M. Wojcik, E. Yanovich, I. Zhitnikov, S. V. Zhukov, D. Zinatulina, A. J. Zsigmond, K. Zuber, G. Zuzel, GERDA Collaboration

Publikováno v: European Physical Journal C: Particles and Fields, Vol 79, Iss 11, Pp 1-24 (2019)

Abstract The GERmanium Detector Array (Gerda) is a low background experiment located at the Laboratori Nazionali del Gran Sasso in Italy, which searches for neutrinoless double-beta decay of $$^{76}$$ 76 Ge into $$^{76}$$ 76 Se+2e$$^-$$ - . Gerda has

Externí odkaz: https://doaj.org/article/0be83c1e9d19421fbece90e02ed87d49

BATMAN: Fast and Accurate Integration of Single-Cell RNA-Seq Datasets via Minimum-Weight Matching

Autor: Igor Mandric, Brian L. Hill, Malika K. Freund, Michael Thompson, Eran Halperin

Publikováno v: iScience, Vol 23, Iss 6, Pp 101185- (2020)

Summary: Single-cell RNA-sequencing (scRNA-seq) is a set of technologies used to profile gene expression at the level of individual cells. Although the throughput of scRNA-seq experiments is steadily growing in terms of the number of cells, large dat

Externí odkaz: https://doaj.org/article/2909a4f5b59d4a5cb7c42672dd077ee0

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Calcineurin activation and scaffolding in Aß‐induced synaptic dysfunction

Autor: Olga Prikhodko, Jennifer L Sanderson, Ronald K Freund, Emily Sullivan, Matthew J Kennedy, Mark L Dell'Acqua

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b01ce4146c7e0dffe75a15a66d8eef14
https://doi.org/10.1002/alz.068826