Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity.

Autor: M, Wadkins Randy, L, Hyatt Janice, P, Yoon Kyoung Jin, L, Morton Christopher, E, Lee Richard, Komath, Damodaran, Paul, Beroza, K, Danks Mary, M, Potter Philip

Publikováno v: Molecular Pharmacology; June 2004, Vol. 65 Issue: 6 p1336-43, 8p

p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).

Autor: Monika, Wierdl, L, Morton Christopher, C, Harris Linda, K, Danks Mary, D, Schuetz John, M, Potter Philip

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; February 2003, Vol. 304 Issue: 2 p699-705, 7p