Zobrazeno 1 - 10
of 94
pro vyhledávání: '"K, Conners"'
Autor:
K-Y. Chen, J.K. Lai, J. Wang, A.M. Russell, K. Conners, M.E. Rutter, B. Condon, F. Tung, L. Kodandapani, B. Chau, X. Zhao, J. Benach, K. Baker, E.J. Hembre, P. Barth
Protein catalysis and allostery require the atomic-level orchestration and motion of residues, ligand, solvent and protein effector molecules, but the ability to design protein activity through precise protein-solvent cooperative interactions has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9215c365a07d3c25e0762826104ab945
https://doi.org/10.1101/2021.09.29.462228
https://doi.org/10.1101/2021.09.29.462228
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
https://doi.org/10.1021/acs.jmedchem.6b01119
Autor:
Min Song, Christopher Groshong, Frances Lu, Yanyun Chen, Steven D. Kahl, Chahrzad Montrose-Rafizadeh, Jayana Pankaj Lineswala, Melbert-Brian Decipulo Saflor, Nichole A. Reynolds, Michaël Genin, Anjana Patel Lewis, Tarun Gheyi, Hsiu-Chiung Yang, Russell E. Madsen, Betty Chau, Chafiq Hamdouchi, Matthew R. Lee, Kenton A. Baker, Anne Reifel Miller, Joseph D. Ho, Keith A. Otto, Kelly L. Wilbur, K. Conners, Jordi Benach, Jonathan P. Riley, Logan Rodgers
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Activation of free fatty acid receptor 1 (GPR40) by synthetic partial and full agonists occur via distinct allosteric sites. A crystal structure of GPR40-TAK-875 complex revealed the allosteric site for the partial agonist. Here we report the 2.76-Å
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e03e48d8920a531cb284d811890c17
https://doi.org/10.1038/s41467-017-01240-w
https://doi.org/10.1038/s41467-017-01240-w
Publikováno v:
Encyclopedia of Clinical Neuropsychology ISBN: 9783319567822
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63822bbd114ffdc1098b1faaa242641b
https://doi.org/10.1007/978-3-319-56782-2_1536-2
https://doi.org/10.1007/978-3-319-56782-2_1536-2
Autor:
Shane Atwell, Christie G. Brouillette, K. Conners, Patricia C. Weber, Jorg Hendle, S.R. Wasserman, William B. Guggino, Diana R. Wetmore, Hal A. Lewis, Tarun Gheyi, R. Romero, Irina I. Protasevich, Feiyu F. Zhang, Frances Lu, John F. Hunt, Logan Rodgers, S. Emtage, Xun Zhao
Publikováno v:
Protein Engineering, Design and Selection. 23:375-384
Upon removal of the regulatory insert (RI), the first nucleotide binding domain (NBD1) of human cystic fibrosis transmembrane conductance regulator (CFTR) can be heterologously expressed and purified in a form that remains stable without solubilizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadd76d9da4d00a6e87bfef5fbefe72a
https://doi.org/10.1093/protein/gzq004
https://doi.org/10.1093/protein/gzq004
Autor:
Peter S. Jensen, Joseph Biederman, Christopher Gillberg, James M. Swanson, Rachel G. Klein, T Sagvolden, C. K. Conners, J Rapoport, M Huss, Nora D. Volkow, Thomas J. Spencer, L. Greenhill, James L. Kennedy, D H Beyer, David Shaffer, J Finkleson
Publikováno v:
Scopus-Elsevier
Objective: To review published algorithms for guiding the use of methylphenidate (MPH) in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adolescents. Methods: A consensus roundtable of 12 experts was convened to revi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a8c3cc0bd0c56e9437f0c3d22bf011
https://doi.org/10.1177/070674370200601s11
https://doi.org/10.1177/070674370200601s11
Publikováno v:
Journal of Attention Disorders. 4:7-13
Objective To develop treatment guidelines for attention-deficit/hyperactivity disorder (ADHD) based upon consensus among physicians and psychologists, particularly concerning aspects of management not yet well established by controlled research. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::870b1f1bcef86d3748641e0a5f3a231a
https://doi.org/10.1177/108705470000401s02
https://doi.org/10.1177/108705470000401s02
Autor:
C. K. Conners, Stephen P. Hinshaw, L. E. Arnold, Julie Sarno Owens, James M. Swanson, William E. Pelham, Betsy Hoza, Helena C. Kraemer
Publikováno v:
Journal of Abnormal Child Psychology. 28:569-583
Using a subsample of 105 children and their parents (100 mothers, 57 fathers) from the Multimodal Treatment Study of Children with ADHD (the MTA), the value of parents' baseline cognitions as predictors of children's treatment outcome at 14 months wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c01a00980f8704353adbd494231befa6
https://doi.org/10.1023/a:1005135232068
https://doi.org/10.1023/a:1005135232068
Autor:
Karen C. Wells, William E. Pelham, L. G. Elliott, Howard Abikoff, Benedetto Vitiello, John S. March, C. K. Conners, P. S. Jensen, Joanne B. Severe, Betsy Hoza, Laurence L. Greenhill, Lily Hechtman, James M. Swanson, L. E. Arnold, Helena C. Kraemer, Stephen P. Hinshaw, Jeffrey H. Newcorn
Publikováno v:
Journal of Abnormal Child Psychology. 28:527-541
Initial moderator analyses in the Multimodal Treatment Study of Children with ADHD (MTA) suggested that child anxiety ascertained by parent report on the Diagnostic Interview Schedule for Children 2.3 (DISC Anxiety) differentially moderated the outco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba6b3071f80d9b2f7bb0ffbf7986b6a
https://doi.org/10.1023/a:1005179014321
https://doi.org/10.1023/a:1005179014321
Autor:
C. K. Conners, James D. A. Parker, Jeffery N. Epstein, G. Sitarenios, E. Sparrow, Drew Erhardt
Publikováno v:
Journal of Attention Disorders. 3:141-151
Background: Although well-standardized behavior rating scales are routinely utilized in children for evaluations of Attention Deficit Hyperactivity Disorder (ADHD), comparable measures for adults with ADHD symptomatology have been sparse. Based on cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b4194e5073dcdd67e3a254b761f6cc6
https://doi.org/10.1177/108705479900300303
https://doi.org/10.1177/108705479900300303