Zobrazeno 1 - 10 of 893 pro vyhledávání: '"K, Conners"'
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4
Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks
Autor: K-Y. Chen, J.K. Lai, J. Wang, A.M. Russell, K. Conners, M.E. Rutter, B. Condon, F. Tung, L. Kodandapani, B. Chau, X. Zhao, J. Benach, K. Baker, E.J. Hembre, P. Barth
Protein catalysis and allostery require the atomic-level orchestration and motion of residues, ligand, solvent and protein effector molecules, but the ability to design protein activity through precise protein-solvent cooperative interactions has not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9215c365a07d3c25e0762826104ab945
https://doi.org/10.1101/2021.09.29.462228
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6
Akademický článek
Test Review: C. K. Conners. Conners Early Childhood Manual.
Autor: Wiley, Colby P., Wedeking, Travis, Galindo, Addy M.
Publikováno v: Journal of Psychoeducational Assessment; Dec2013, Vol. 31 Issue 6, p606-610, 5p
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7
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
Autor: Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v: Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
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8
Structural basis for GPR40 allosteric agonism and incretin stimulation
Autor: Min Song, Christopher Groshong, Frances Lu, Yanyun Chen, Steven D. Kahl, Chahrzad Montrose-Rafizadeh, Jayana Pankaj Lineswala, Melbert-Brian Decipulo Saflor, Nichole A. Reynolds, Michaël Genin, Anjana Patel Lewis, Tarun Gheyi, Hsiu-Chiung Yang, Russell E. Madsen, Betty Chau, Chafiq Hamdouchi, Matthew R. Lee, Kenton A. Baker, Anne Reifel Miller, Joseph D. Ho, Keith A. Otto, Kelly L. Wilbur, K. Conners, Jordi Benach, Jonathan P. Riley, Logan Rodgers
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Activation of free fatty acid receptor 1 (GPR40) by synthetic partial and full agonists occur via distinct allosteric sites. A crystal structure of GPR40-TAK-875 complex revealed the allosteric site for the partial agonist. Here we report the 2.76-Å
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e03e48d8920a531cb284d811890c17
https://doi.org/10.1038/s41467-017-01240-w
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10
Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant
Autor: Shane Atwell, Christie G. Brouillette, K. Conners, Patricia C. Weber, Jorg Hendle, S.R. Wasserman, William B. Guggino, Diana R. Wetmore, Hal A. Lewis, Tarun Gheyi, R. Romero, Irina I. Protasevich, Feiyu F. Zhang, Frances Lu, John F. Hunt, Logan Rodgers, S. Emtage, Xun Zhao
Publikováno v: Protein Engineering, Design and Selection. 23:375-384
Upon removal of the regulatory insert (RI), the first nucleotide binding domain (NBD1) of human cystic fibrosis transmembrane conductance regulator (CFTR) can be heterologously expressed and purified in a form that remains stable without solubilizing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadd76d9da4d00a6e87bfef5fbefe72a
https://doi.org/10.1093/protein/gzq004
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