Zobrazeno 1 - 10
of 159
pro vyhledávání: '"K, Clawson"'
Autor:
B. W. Butler, N. S. Wagenbrenner, J. M. Forthofer, B. K. Lamb, K. S. Shannon, D. Finn, R. M. Eckman, K. Clawson, L. Bradshaw, P. Sopko, S. Beard, D. Jimenez, C. Wold, M. Vosburgh
Publikováno v:
Atmospheric Chemistry and Physics, Vol 15, Iss 7, Pp 3785-3801 (2015)
A number of numerical wind flow models have been developed for simulating wind flow at relatively fine spatial resolutions (e.g., ~ 100 m); however, there are very limited observational data available for evaluating these high-resolution models. This
Externí odkaz:
https://doaj.org/article/6c37001b8aba4b798d793b7de4804411
Autor:
Kristy Kikly, Howard Barff Broughton, William Chang, Selma Sapmaz, Richard Morphy, Holly A. Bina, Jim D. Durbin, Sherry Y Guo, Timothy Ivo Richardson, Jimmy P Steele, Ryan Edward Stites, Brian G. Getman, Vaught Grant Matthews, Veavi Ching-Yun Chang, Pamela K. Shetler, Greg L Durst, Denise D Edmondson, Rob Barr, Helene Rudyk, Charles Willis Lugar, Nita J. Patel, Christian Alexander Clarke, Kelly Wayne Furness, Nicole E New, David K. Clawson, Keith R. Stayrook, Mark Chambers, Brian Michael Mathes, Stephanie L. Stout, Wendy H. Gough
Publikováno v:
Journal of Medicinal Chemistry. 64:5470-5484
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a80dc241f7e50c8ddb367cc37ea913c
https://doi.org/10.1021/acs.jmedchem.0c01918
https://doi.org/10.1021/acs.jmedchem.0c01918
Autor:
Charles W, Lugar, Christian A, Clarke, Richard, Morphy, Helene, Rudyk, Selma, Sapmaz, Ryan E, Stites, Grant M, Vaught, Kelly, Furness, Howard B, Broughton, Greg L, Durst, David K, Clawson, Stephanie L, Stout, Sherry Y, Guo, Jim D, Durbin, Keith R, Stayrook, Denise D, Edmondson, Kristy, Kikly, Nicole E, New, Holly A, Bina, Mark G, Chambers, Pamela, Shetler, William Y, Chang, Veavi Ching-Yun, Chang, Rob, Barr, Wendy H, Gough, Jimmy P, Steele, Brian, Getman, Nita, Patel, Brian M, Mathes, Timothy I, Richardson
Publikováno v:
Journal of medicinal chemistry. 64(9)
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef03d39fb502b855beadc34c7a19e1e7
https://pubmed.ncbi.nlm.nih.gov/33852312
https://pubmed.ncbi.nlm.nih.gov/33852312
Autor:
Assimina A. Pelegri, James Zheng, James Neal Singletary, Ioannis Chasiotis, Suzanne Horner, Jan K. Clawson, Korhan Sahin
Publikováno v:
Polymer. 140:96-106
The evolution of crystalline domain orientation vs. mechanical properties of aramid fibers under mechanical loading was investigated for initial crystalline domain orientations between 16.7° and 9.7°. The latter resulted in a broad range of longitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f6bf9d121df6a8e62cfcc732f582d8
https://doi.org/10.1016/j.polymer.2018.02.018
https://doi.org/10.1016/j.polymer.2018.02.018
Autor:
Frances Lu, Bryan G. Johnson, Daniel Ursu, Joan H. Carter, Lisa M. Broad, Kofi Adragni, Shane Atwell, Jing Wang, David K. Clawson, Beverly A. Heinz, Steven P. Swanson, James A. Monn, Qi Chen, Helene E. Sanger, David B. Shaw, Steven Marc Massey, Xushan Wang, Marijane Russell, Steven S. Henry, Junliang Hao, Rajni M. Bhardwaj, Diseroad Benjamin Alan, David L. McKinzie, Brian G. Getman, John T. Catlow
Publikováno v:
Journal of Medicinal Chemistry. 61:2303-2328
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu3) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify potent, selective, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fd3a986aac486e41e6ea738f1a4465
https://doi.org/10.1021/acs.jmedchem.7b01481
https://doi.org/10.1021/acs.jmedchem.7b01481
Autor:
Michael Lahn, Faming Zhang, William T. McMillen, Jeremy R. Graff, Rikke B. Holmgaard, Chandrasekar V. Iyer, Jason Manro, Bryan D. Anderson, Douglas W. Beight, Maria Jose Lallena, Kyla Driscoll, Lei Yan, J. Scott Sawyer, Michael Kalos, Karen S. Britt, David K. Clawson, Philip W. Iversen, Rolf A. Brekken, Karim A. Benhadji, Xiaohong Xu, Durisala Desaiah, Jonathan Michael Yingling, Huocong Huang
Publikováno v:
Oncotarget
Transforming growth factor-β (TGFβ) is an important driver of tumor growth via intrinsic and extrinsic mechanisms, and is therefore an attractive target for developing cancer therapeutics. Using preclinical models, we characterized the anti-tumor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d8441d71dc2f3af0b1cfba12364fde
https://doi.org/10.18632/oncotarget.23795
https://doi.org/10.18632/oncotarget.23795
Autor:
Holly A. Bina, Bryan Edward Jones, Yan Ji, Jirong Lu, Victor J. Wroblewski, Robert J. Benschop, Qing Chai, Stacy Torgerson, Barrett Allan, James Nelson, Shane Atwell, Ningjie Hu, Chi-Kin Chow, Yu Tian, David K. Clawson, Mahmoud Ghanem, Barbra Barmettler, J.R. Fitchett, Joseph Manetta
Publikováno v:
MAbs
We describe a bispecific dual-antagonist antibody against human B cell activating factor (BAFF) and interleukin 17A (IL-17). An anti-IL-17 single-chain variable fragment (scFv) derived from ixekizumab (Taltz®) was fused via a glycine-rich linker to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875fe1f65f13696c2fbf292fb27f362d
https://pubmed.ncbi.nlm.nih.gov/31181988
https://pubmed.ncbi.nlm.nih.gov/31181988
Akademický článek
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Autor:
Corey A. Richards, Matthew K. Clawson, J. A. N. T. Soares, Christian R. Ocier, Neil A. Krueger, Daniel Bacon-Brown, Paul V. Braun
Publikováno v:
Optical Materials Express. 10:868
The effect of spatially varying birefringence on the focusing behavior of porous silicon (PSi) and porous silicon dioxide (PSiO2) gradient refractive index (GRIN) lenses is investigated. Both materials attain broad, tunable refractive indexes and bir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a42420d4a02b82c0133d2efaa10fc26
https://doi.org/10.1364/ome.385013
https://doi.org/10.1364/ome.385013
Publikováno v:
Polymer. 186:122034
Novel shear experiments with homopolymer and copolymer high performance aramid fibers were conducted via a custom designed MEMS device to examine the correlation between shear and tensile strength. A finite element analysis was utilized to design the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5114bb5ba590dc9771f85867b89ef233
https://doi.org/10.1016/j.polymer.2019.122034
https://doi.org/10.1016/j.polymer.2019.122034