Výsledky vyhledávání - "K, Chennakesava Rao"

Synthetic investigation on chirally pure Mannich derivatives of pseudophenylpropanolamine and their anticancer properties against HepG-2 cells with inhibition of JAK2/STAT3

Autor: Naoki Yamamoto, K. Chennakesava Rao, K. Easwaramoorthi, Chandrasekar Balachandran, Y. Arun, Akinao Okamoto, Nobuhiko Emi, Y. Inaguma, Paramasivam T. Perumal

Publikováno v: RSC Advances. 6:96946-96962

A novel series of Mannich derivatives of 3a–g and 3a′–g′ were designed and synthesized from pseudophenylpropanolamine (Ψ-PPA). The stereo chemical aspects of the synthesized compounds were studied and all compounds were well characterized wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b5f3b82d9dfb60e9eaf8dd08e07d268
https://doi.org/10.1039/c6ra22480f

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Synthesis of BF3 catalyzed Mannich derivatives with excellent ee from phenylpropanolamine, study of their antimicrobial activity and molecular docking

Autor: P. T. Perumal, K. Easwaramoorthi, K. S. Muralidhara Rao, Nobuhiko Emi, Chandrasekar Balachandran, Y. Arun, K. Chennakesava Rao, M. Govindhan, T. Prakasam

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:4232-4238

Antimicrobial agents 4a–g and 5a–g with very good potency were synthesized with 100% ee from phenylpropanolamine (norephedrine) by BF3 catalyzed three components one pot Mannich reaction in good yields. Obtained compounds were characterized using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f49cc29b461a4a1c43efd50ae12fc028
https://doi.org/10.1016/j.bmcl.2015.07.096

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Synthesis of novel 4-hydroxycoumarin derivatives: evaluation of antimicrobial, antioxidant activities and its molecular docking studies

Autor: K. Subramanian, M. Govindhan, K. Easwaramoorthi, P. Senthilkumar, Paramasivam T. Perumal, K. Chennakesava Rao

Publikováno v: Medicinal Chemistry Research. 24:4181-4190

A series of novel 4-hydroxycoumarin derivatives 4a–n were synthesized by treating 2-(2-oxo-2H-chromen-4-yloxy)acetic acid 3 with various amines. Acid 3 was obtained from the hydrolysis of corresponding ester 2 which was prepared from 4-hydroxycouma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db8df854c8093472fc3a4acbe568cc45
https://doi.org/10.1007/s00044-015-1448-z

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Synthesis of novel 1,4-disubstituted 1,2,3-triazolo-bosentan derivatives – evaluation of antimicrobial and anticancer activities and molecular docking

Autor: K. Chennakesava Rao, A. Jeya Rajendran, K. Easwaramoorthi, Veeramuthu Duraipandiyan, Chandrasekar Balachandran, Y. Arun, Naif Abdullah Al-Dhabi, Paramasivan T. Perumal, Sakkarapalayam M. Mahalingam, Nobuhiko Emi

Publikováno v: RSC Advances. 5:105266-105278

Novel 1,4-disubstituted 1,2,3-triazolo bosentan derivatives 1a–n from bosentan 2 were synthesized in good yields by sequential chlorination, azidation followed by Cu(I) catalyzed 1,3-dipolar cycloaddition. All obtained compounds 1a–n were evaluat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08ef12b8127797718f15c30ddc51a7d4
https://doi.org/10.1039/c5ra18618h

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Synthesis, antimicrobial and molecular docking studies of enantiomerically pure N-alkylated β-amino alcohols from phenylpropanolamines

Autor: Paramasivam T. Perumal, Chandrasekar Balachandran, K. Easwaramoorthi, K. Chennakesava Rao, T. Prakasam, T. Eswara Yuvaraj, Y. Arun

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:3057-3063

Enantiomerically pure N-alkylated β-amino alcohols 1a, 1a', 1c, 1c', 1d, 1d', 1e and 1e', with ee 100% have been synthesized from phenylpropanolamines 2. Effect of the neighboring chiral environment on the newly formed chiral center has been studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f389fd9c25d27573d62b3572b7780d
https://doi.org/10.1016/j.bmcl.2014.05.027

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ChemInform Abstract: Synthesis of BF3Catalyzed Mannich Derivatives with Excellent ee from Phenylpropanolamine, Study of Their Antimicrobial Activity and Molecular Docking

Autor: Chandrasekar Balachandran, K. Easwaramoorthi, P. T. Perumal, K. S. Muralidhara Rao, K. Chennakesava Rao, Nobuhiko Emi, M. Govindhan, T. Prakasam, Y. Arun

Publikováno v: ChemInform. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f65dfe3401e8fd63de47f55c652de27
https://doi.org/10.1002/chin.201605095

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Synthesis of BF₃ catalyzed Mannich derivatives with excellent ee from phenylpropanolamine, study of their antimicrobial activity and molecular docking

Autor: K, Chennakesava Rao, K, Easwaramoorthi, Y, Arun, C, Balachandran, K S, Muralidhara Rao, M, Govindhan, Nobuhiko, Emi, T, Prakasam, P T, Perumal

Publikováno v: Bioorganicmedicinal chemistry letters. 25(19)

Antimicrobial agents 4a-g and 5a-g with very good potency were synthesized with 100% ee from phenylpropanolamine (norephedrine) by BF3 catalyzed three components one pot Mannich reaction in good yields. Obtained compounds were characterized using spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99cd140c950fad620823363802b40a36
https://pubmed.ncbi.nlm.nih.gov/26296475

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