Zobrazeno 1 - 10
of 581
pro vyhledávání: '"K, Chalmers"'
Autor:
Mattia Deluigi, Lena Morstein, Matthias Schuster, Christoph Klenk, Lisa Merklinger, Riley R. Cridge, Lazarus A. de Zhang, Alexander Klipp, Santiago Vacca, Tasneem M. Vaid, Peer R. E. Mittl, Pascal Egloff, Stefanie A. Eberle, Oliver Zerbe, David K. Chalmers, Daniel J. Scott, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
This study reports the X-ray structure of the α1B-adrenergic G protein-coupled receptor bound to an inverse agonist, and unveils key determinants of subtype-selective ligand binding that may help the design of aminergic drugs with fewer side-effects
Externí odkaz:
https://doaj.org/article/9eae3c81d8e34aff9e67ac17ad3df5fe
Autor:
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Publikováno v:
Molecules, Vol 28, Iss 7, p 3103 (2023)
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 rema
Externí odkaz:
https://doaj.org/article/c7cd4c19945d4662b4ccbad1fae4b33e
Autor:
Vivian Cody, Jia Q. Truong, Bruce A. Holdsworth, Jessica K. Holien, Samantha J. Richardson, David K. Chalmers, David J. Craik
Publikováno v:
Molecules, Vol 27, Iss 21, p 7206 (2022)
Human transthyretin (hTTR) can form amyloid deposits that accumulate in nerves and organs, disrupting cellular function. Molecules such as tafamidis that bind to and stabilize the TTR tetramer can reduce such amyloid formation. Here, we studied the i
Externí odkaz:
https://doaj.org/article/456a38735a2245eab13bbe0e53f542cb
Publikováno v:
Journal of Chemical Information and Modeling. 63:3043-3053
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c89fcf4152c4d424352f0e9905a5cc
https://doi.org/10.1021/acs.jcim.2c01237
https://doi.org/10.1021/acs.jcim.2c01237
Autor:
Wenxiao K. Yue, Tianxia Zhang, Rekha Shandre Mugan, Nicholas Barlow, David K. Chalmers, Colin W. Pouton, Philip E. Thompson
Publikováno v:
Journal of Medicinal Chemistry. 66:3273-3283
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::622b532371e7699c72f2f79be3836a42
https://doi.org/10.1021/acs.jmedchem.2c01587
https://doi.org/10.1021/acs.jmedchem.2c01587
Publikováno v:
International Journal of Economics and Financial Issues, Vol 10, Iss 5 (2020)
The aim of this study was to contribute to the literature debate on financial behavior and corporate capital structure by focusing on two aspects. First of all, we analyzed how the intensity of exports and therefore the percentage weight of foreign s
Externí odkaz:
https://doaj.org/article/3a491e122c754baaa00c7d32c84fb59f
Autor:
Luke Richards, Adrian Lutz, David K. Chalmers, Ailsa Jarrold, Tim Bowser, Geoffrey W. Stevens, Sally L. Gras
Publikováno v:
Biotechnology Reports, Vol 24, Iss , Pp - (2019)
Cytochrome P450 enzymes are a promising tool for the late-stage diversification of lead drug candidates and can provide an alternative route to structural modifications that are difficult to achieve with synthetic chemistry. In this study, a library
Externí odkaz:
https://doaj.org/article/42595d0cef4d49519d7152a942e1fe52
Autor:
Billy J. Williams-Noonan, Melissa N. Speer, Tu C. Le, Maiada M. Sadek, Philip E. Thompson, Raymond S. Norton, Elizabeth Yuriev, Nicholas Barlow, David K. Chalmers, Irene Yarovsky
Publikováno v:
Journal of Chemical Information and Modeling. 62:4605-4619
The ability to predict cell-permeable candidate molecules has great potential to assist drug discovery projects. Large molecules that lie beyond the Rule of Five (bRo5) are increasingly important as drug candidates and tool molecules for chemical bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1f09dc8c084643e7256bb460c5debc
https://doi.org/10.1021/acs.jcim.2c00809
https://doi.org/10.1021/acs.jcim.2c00809
Autor:
Jeffrey Seow, Sreedam C. Das, Rodrigo A. V. Morales, Ricardo Ataide, Bankala Krishnarjuna, Mitchell Silk, David K. Chalmers, Jack Richards, Robin F. Anders, Christopher A. MacRaild, Raymond S. Norton
Publikováno v:
Vaccines, Vol 9, Iss 8, p 855 (2021)
The malaria vaccine candidate merozoite surface protein 2 (MSP2) has shown promise in clinical trials and is in part responsible for a reduction in parasite densities. However, strain-specific reductions in parasitaemia suggested that polymorphic reg
Externí odkaz:
https://doaj.org/article/153ed481a87347559293e8de6e143253
Publikováno v:
Molecular Pharmaceutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a76a4479f5d1231774688a96233e733
https://doi.org/10.1021/acs.molpharmaceut.3c00049
https://doi.org/10.1021/acs.molpharmaceut.3c00049