Zobrazeno 1 - 10 of 409 pro vyhledávání: '"K, Brocklehurst"'
2
Evidence for independent molecular identity and functional interaction of the haemagglutinin and cysteine proteinase (gingivain) of Porphyromonas gingivalis
Autor: Haroun N. Shah, Ann Progulske-Fox, Saheer E. Gharbia, K. Brocklehurst
Publikováno v: Journal of Medical Microbiology. 36:239-244
Summary The sequence of events involved in haemagglutination and lysis of erythrocytes by washed cells, vesicles and the culture supernate of Porphyromonas gingivalis strain W83 was monitored by 51Cr release and transmission electronmicroscopy. All p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22feed393950d9ab8db3a9791c59e918
https://doi.org/10.1099/00222615-36-4-239
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3
Variation in aspects of cysteine proteinase catalytic mechanism deduced by spectroscopic observation of dithioester intermediates, kinetic analysis and molecular dynamics simulations
Autor: J D, Reid, S, Hussain, S K, Sreedharan, T S, Bailey, S, Pinitglang, E W, Thomas, C S, Verma, K, Brocklehurst
Publikováno v: The Biochemical journal. 357(Pt 2)
The possibility of a slow post-acylation conformational change during catalysis by cysteine proteinases was investigated by using a new chromogenic substrate, N-acetyl-Phe-Gly methyl thionoester, four natural variants (papain, caricain, actinidin and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d14bd327ec10247938739960ccf6b30
https://pubmed.ncbi.nlm.nih.gov/11439083
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4
Ionization characteristics and chemical influences of aspartic acid residue 158 of papain and caricain determined by structure-related kinetic and computational techniques: multiple electrostatic modulators of active-centre chemistry
Autor: M A, Noble, S, Gul, C S, Verma, K, Brocklehurst
Publikováno v: The Biochemical journal.
The pK(a) of (Asp(158))-CO(2)H of papain (EC 3.4.22.2) was determined as 2.8 by using 4-chloro-7-nitrobenzofurazan (Nbf-Cl) as a reactivity probe targeted on the thiolate anion component of the Cys(25)/His(159) nucleophilic-acid/base motif of the cat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b173d5c27e7543e49d0ce5b51f6aa9b8
https://pubmed.ncbi.nlm.nih.gov/11042128
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6
Comparative studies on the 5-aminolaevulinic acid dehydratases from Pisum sativum, Escherichia coli and Saccharomyces cerevisiae
Autor: N M, Senior, K, Brocklehurst, J B, Cooper, S P, Wood, P, Erskine, P M, Shoolingin-Jordan, P G, Thomas, M J, Warren
Publikováno v: The Biochemical journal. 320
5-Aminolaevulinic acid dehydratase (ALAD) is an essential enzyme in most organisms, catalysing an inaugural step in the tetrapyrrole biosynthetic pathway, the Knorr-type condensation reaction of two molecules of 5-aminolaevulinic acid (ALA) to form t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::491030f3f6c4fc62704dc4f29b37d6b9
https://pubmed.ncbi.nlm.nih.gov/8973546
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