Zobrazeno 1 - 10
of 2 031
pro vyhledávání: '"K, Bradley"'
Autor:
Austin M. Gabel, Andrea E. Belleville, James D. Thomas, Jose Mario Bello Pineda, Robert K. Bradley
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood. Results We describe an unbiased
Externí odkaz:
https://doaj.org/article/3e221b88df34409f92e5f01950f1eca2
Autor:
J. E. Ralph, J. S. Ross, A. B. Zylstra, A. L. Kritcher, H. F. Robey, C. V. Young, O. A. Hurricane, A. Pak, D. A. Callahan, K. L. Baker, D. T. Casey, T. Döppner, L. Divol, M. Hohenberger, S. Le Pape, P. K. Patel, R. Tommasini, S. J. Ali, P. A. Amendt, L. J. Atherton, B. Bachmann, D. Bailey, L. R. Benedetti, L. Berzak Hopkins, R. Betti, S. D. Bhandarkar, J. Biener, R. M. Bionta, N. W. Birge, E. J. Bond, D. K. Bradley, T. Braun, T. M. Briggs, M. W. Bruhn, P. M. Celliers, B. Chang, T. Chapman, H. Chen, C. Choate, A. R. Christopherson, D. S. Clark, J. W. Crippen, E. L. Dewald, T. R. Dittrich, M. J. Edwards, W. A. Farmer, J. E. Field, D. Fittinghoff, J. Frenje, J. Gaffney, M. Gatu Johnson, S. H. Glenzer, G. P. Grim, S. Haan, K. D. Hahn, G. N. Hall, B. A. Hammel, J. Harte, E. Hartouni, J. E. Heebner, V. J. Hernandez, H. W. Herrmann, M. C. Herrmann, D. E. Hinkel, D. D. Ho, J. P. Holder, W. W. Hsing, H. Huang, K. D. Humbird, N. Izumi, L. C. Jarrott, J. Jeet, O. Jones, G. D. Kerbel, S. M. Kerr, S. F. Khan, J. Kilkenny, Y. Kim, H. Geppert-Kleinrath, V. Geppert-Kleinrath, C. Kong, J. M. Koning, J. J. Kroll, M. K. G. Kruse, B. Kustowski, O. L. Landen, S. Langer, D. Larson, N. C. Lemos, J. D. Lindl, T. Ma, M. J. MacDonald, B. J. MacGowan, A. J. Mackinnon, S. A. MacLaren, A. G. MacPhee, M. M. Marinak, D. A. Mariscal, E. V. Marley, L. Masse, K. D. Meaney, N. B. Meezan, P. A. Michel, M. Millot, J. L. Milovich, J. D. Moody, A. S. Moore, J. W. Morton, T. J. Murphy, K. Newman, J.-M. G. Di Nicola, A. Nikroo, R. Nora, M. V. Patel, L. J. Pelz, J. L. Peterson, Y. Ping, B. B. Pollock, M. Ratledge, N. G. Rice, H. G. Rinderknecht, M. Rosen, M. S. Rubery, J. D. Salmonson, J. Sater, S. Schiaffino, D. J. Schlossberg, M. B. Schneider, C. R. Schroeder, H. A. Scott, S. M. Sepke, K. Sequoia, M. W. Sherlock, S. Shin, V. A. Smalyuk, B. K. Spears, P. T. Springer, M. Stadermann, S. Stoupin, D. J. Strozzi, L. J. Suter, C. A. Thomas, R. P. J. Town, C. Trosseille, E. R. Tubman, P. L. Volegov, C. R. Weber, K. Widmann, C. Wild, C. H. Wilde, B. M. Van Wonterghem, D. T. Woods, B. N. Woodworth, M. Yamaguchi, S. T. Yang, G. B. Zimmerman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Indirect Drive Inertial Confinement Fusion Experiments on the National Ignition Facility (NIF) have achieved a burning plasma state with neutron yields exceeding 170 kJ, roughly 3 times the prior record and a necessary stage for igniting pla
Externí odkaz:
https://doaj.org/article/269b30b0fbbf4e519e1e759f9f698844
An autoregulatory poison exon in Smndc1 is conserved across kingdoms and influences organism growth.
Autor:
Andrea E Belleville, James D Thomas, Jackson Tonnies, Austin M Gabel, Andrea Borrero Rossi, Priti Singh, Christine Queitsch, Robert K Bradley
Publikováno v:
PLoS Genetics, Vol 20, Iss 8, p e1011363 (2024)
Many of the most highly conserved elements in the human genome are "poison exons," alternatively spliced exons that contain premature termination codons and permit post-transcriptional regulation of mRNA abundance through induction of nonsense-mediat
Externí odkaz:
https://doaj.org/article/2702abd2857a40798e0927e14c8e9f70
Autor:
Austin M. Gabel, Andrea E. Belleville, James D. Thomas, Siegen A. McKellar, Taylor R. Nicholas, Toshihiro Banjo, Edie I. Crosse, Robert K. Bradley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Alternative polyadenylation (APA) is strikingly dysregulated in many cancers. Although global APA dysregulation is frequently associated with poor prognosis, the importance of most individual APA events is controversial simply because few ha
Externí odkaz:
https://doaj.org/article/38f1b82c8b184f27a198e5de36ed4995
Publikováno v:
eLife, Vol 12 (2024)
Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation tha
Externí odkaz:
https://doaj.org/article/fd7d1d0ccf2346e9aa165a47751997e3
Autor:
H. Sio, A. Krygier, D. G. Braun, R. E. Rudd, S. A. Bonev, F. Coppari, M. Millot, D. E. Fratanduono, N. Bhandarkar, M. Bitter, D. K. Bradley, P. C. Efthimion, J. H. Eggert, L. Gao, K. W. Hill, R. Hood, W. Hsing, N. Izumi, G. Kemp, B. Kozioziemski, O. L. Landen, K. Le Galloudec, T. E. Lockard, A. Mackinnon, J. M. McNaney, N. Ose, H.-S. Park, B. A. Remington, M. B. Schneider, S. Stoupin, D. B. Thorn, S. Vonhof, C. J. Wu, Y. Ping
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract Large laser facilities have recently enabled material characterization at the pressures of Earth and Super-Earth cores. However, the temperature of the compressed materials has been largely unknown, or solely relied on models and simulations
Externí odkaz:
https://doaj.org/article/258382f7cab343e8ac2471967b385953
Publikováno v:
Journal of Cannabis Research, Vol 5, Iss 1, Pp 1-6 (2023)
Abstract Background Delta-8 tetrahydrocannabinol (THC) is a psychoactive cannabinoid from the cannabis plant that can be synthetically converted from cannabidiol (CBD). Most states permit the full or restricted sale of hemp and hemp-derived CBD produ
Externí odkaz:
https://doaj.org/article/944c8cb6e1c841c4ad004ba99c18a696
Autor:
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SR
Externí odkaz:
https://doaj.org/article/7052b61a50574159ad243b8dd55f38e5
Publikováno v:
Crop, Forage & Turfgrass Management; Dec2024, Vol. 10 Issue 2, p1-9, 9p