Výsledky vyhledávání - "K, Blumenthal"

Akademický článek

Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

Autor: Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Simon M. Sandford, Susan S. Taylor, Gianluigi Veglia

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric c

Externí odkaz: https://doaj.org/article/43c1fcd3a0854b83a040ab4779192c9e

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Periodical

Increased rate of major birth malformations in infants with neonatal “asymmetric crying face”: A hospital‐based cohort studyHow to cite this article: Dubnov‐Raz G, Merlob P, Geva‐Dayan K, Blumenthal D, Finkelstein Y. 2007. Increased rate of major birth malformations in infants with neonatal “asymmetric crying face”: A hospital‐based cohort study. Am J Med Genet Part A 143A:305–310.

Autor: Dubnov‐Raz, Gal, Merlob, Paul, Geva‐Dayan, Karen, Blumenthal, Danith, Finkelstein, Yaron

Publikováno v: American Journal of Medical Genetics. Part A; February 2007, Vol. 143 Issue: 4 p305-310, 6p

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Akademický článek

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

Autor: Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David DT Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia

Publikováno v: eLife, Vol 9 (2020)

In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.

Externí odkaz: https://doaj.org/article/34c13da9463648a9980c22009c9c1bf8

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Akademický článek

Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

Autor: Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Sanford M. Simon, Susan S. Taylor, Gianluigi Veglia

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)

A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-02006-3

Externí odkaz: https://doaj.org/article/7c24fd9db8f04d64a2a736102b658354

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517 Clinical manifestations of DRESS in pediatric patients

Autor: A.J. Ezeofor, Y. Lo, K. Blumenthal, L. Zhou, D. Kroshinsky

Publikováno v: Journal of Investigative Dermatology. 143:S89

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfe93ed87592b7085050fb0022f4af7f
https://doi.org/10.1016/j.jid.2023.03.523

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Rational design, synthesis, and evaluation of uncharged, 'smart' bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

Autor: Xiaolin Cheng, Carlo Ballatore, Xiaotian Kong, Zoran Radić, Palmer Taylor, Lukas Gorecki, Andrey Kovalevsky, Donald K. Blumenthal, Oksana Gerlits

Publikováno v: The Journal of biological chemistry, vol 295, iss 13
J Biol Chem

Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime–based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into the central nervous syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4649c3e494b09cb5e29a444296e402ce
https://doi.org/10.1074/jbc.ra119.012400

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Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering

Autor: Oksana, Gerlits, Mikolai, Fajer, Xiaolin, Cheng, Donald K, Blumenthal, Zoran, Radić, Andrey, Kovalevsky

Publikováno v: Structure. 30:1538-1549.e3

Organophosphorus (OP) compounds, including nerve agents and some pesticides, covalently bind to the catalytic serine of human acetylcholinesterase (hAChE), thereby inhibiting acetylcholine hydrolysis necessary for efficient neurotransmission. Oxime a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26207fbde3999e2ea3fe56810bf73f2
https://doi.org/10.1016/j.str.2022.09.006

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Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects

Autor: Palmer Taylor, Andrey Kovalevsky, Donald K. Blumenthal, Zoran Radić, Mikolai Fajer, Puneet Juneja, Kwok-Yiu Ho, Jacqueline Rohrer, Oksana Gerlits, Xiaolin Cheng

Publikováno v: The Journal of biological chemistry, vol 297, iss 3
The Journal of Biological Chemistry

Acetylcholinesterase (EC 3.1.1.7), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, C-terminally disulfide-linked homodimers, homotetramers, and up to three tetram

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03351602374b055c8336577d63112ba
https://escholarship.org/uc/item/46z0j5wg

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