Zobrazeno 1 - 10
of 137
pro vyhledávání: '"K, Biron"'
Autor:
Karen K. Biron
Publikováno v:
Antiviral Research. 71:154-163
Cytomegalovirus infections are associated with severe morbidity and mortality is patients at risk for disease because of immune system disabilities; in particular, recipients of stem cell (HSCT) or solid organ (SOT) transplants. There are three syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f67e7ff8690f40da6c2e2c655ea5d4
https://doi.org/10.1016/j.antiviral.2006.05.002
https://doi.org/10.1016/j.antiviral.2006.05.002
Autor:
Earl R. Kern, Karen K. Biron, Stephanie L. Williams, Emma A. Harden, Leroy B. Townsend, Deborah J. Bidanset, Mark R. Underwood, John C. Drach, Nicole L. Kushner, Caroll B. Hartline
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:2186-2192
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), and human herpesvirus 8 (HHV-8) are responsible for a number of clinical manifestations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c9e586affcd539663967b57a79ea83
https://doi.org/10.1128/aac.47.7.2186-2192.2003
https://doi.org/10.1128/aac.47.7.2186-2192.2003
Autor:
Paula M. Krosky, Karen K. Biron, Michelle G. Davis, Roger G. Ptak, Katherine Z. Borysko, M. Reza Nassiri, Leroy B. Townsend, Rodrigo V. Devivar, John C. Drach
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:478-486
We have previously reported that 2,5,6-trichloro-1-(β- d -ribofuranosyl)benzimidazole (TCRB) and its 2-bromo analog (2-bromo-5,6-dichloro-1-(β- d -ribofuranosy)benzimidazole [BDCRB]) are potent and selective inhibitors of human cytomegalovirus (HCM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab3bd8f3c2123f6ee17e3a8164fcfbb
https://doi.org/10.1128/aac.46.2.478-486.2002
https://doi.org/10.1128/aac.46.2.478-486.2002
Autor:
Huiling Hu, Douglas A. Jabs, David V. Weinberg, Michael Forman, James P. Dunn, Karen K. Biron, Barbara K. Martin, Fausto Baldanti, Janet L. Davis
Publikováno v:
American Journal of Ophthalmology. 132:700-710
PURPOSE: Cytomegalovirus retinitis is the most common intraocular infection in patients with acquired immunodeficiency syndrome (AIDS). With prolonged suppressive anticytomegalovirus maintenance therapy, resistance occurs in over 25% of patients. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c818f8723c424658f6a54d1e212f36f9
https://doi.org/10.1016/s0002-9394(01)01161-8
https://doi.org/10.1016/s0002-9394(01)01161-8
Autor:
Lloyd Frick, John C. Drach, Joseph H. Chan, Dean W. Selleseth, Stanley D. Chamberlain, George W. Koszalka, Ernest H. Dark, Robert J. Harvey, Karen K. Biron, Leroy B. Townsend, R E Dornsife, Michelle G. Davis
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:101-123
A series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94) were synthesized and evaluated for activity against human cytomegalovirus (HCMV) and for cytotoxicity. The 2-subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e3c56352778834b481dfb60df98d2e
https://doi.org/10.1080/15257770008032999
https://doi.org/10.1080/15257770008032999
Autor:
Karen K. Biron, Eric A. Meade, John E. Reardon, Wayne H. Miller, Lilia M. Beauchamp, Albert A. Smith, Charles A. Goss, Richard L. Miller
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:341-356
A racemic mixture of ganciclovir phosphonate was resolved by stereoselective phosphorylation using GMP kinase. The R-enantiomer of ganciclovir phosphonate was active against human cytomegalovirus but the S-enantiomer was less active. We show that ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4a92a1dfc121d556957acf25d5856b
https://doi.org/10.1080/15257770008033013
https://doi.org/10.1080/15257770008033013
Publikováno v:
Journal of Virology. 73:7271-7277
Although a number of antiviral drugs inhibit replication of Epstein-Barr virus (EBV) in cell culture, and acyclovir (ACV) suppresses replication in vivo, currently available drugs have not proven effective for treatment of EBV-associated diseases oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb56ddd02067902615b7b14a1f9b09f1
https://doi.org/10.1128/jvi.73.9.7271-7277.1999
https://doi.org/10.1128/jvi.73.9.7271-7277.1999
Autor:
Roger G. Ptak, Paula M. Krosky, Kathryne W.-H. Feng, John C. Drach, Mark R. Underwood, Allison C. Westerman, Leroy B. Townsend, Steven R. Turk, Karen K. Biron, Rajeev K. Jain
Publikováno v:
Journal of Virology. 72:4721-4728
2,5,6-Trichloro-1-β- d -ribofuranosyl benzimidazole (TCRB) is a potent and selective inhibitor of human cytomegalovirus (HCMV) replication. TCRB acts via a novel mechanism involving inhibition of viral DNA processing and packaging. Resistance to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de663d7851e8f6935bf8b79bdc934785
https://doi.org/10.1128/jvi.72.6.4721-4728.1998
https://doi.org/10.1128/jvi.72.6.4721-4728.1998
Autor:
Antonella Sarasini, Fausto Baldanti, Mark R. Underwood, Sylvia C. Stanat, Enrico Silini, Sunwen Chou, Karen K. Biron, Giuseppe Gerna
Publikováno v:
Scopus-Elsevier
Three human cytomegalovirus (HCMV) strains (VR4760, VR4955, and VR5120) showing double resistance to ganciclovir (GCV) and foscarnet (PFA) were isolated from three patients with AIDS who underwent multiple sequential courses of therapy with GCV and P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c0fe328c13771d01d49a7f5b990340
https://doi.org/10.1128/jvi.70.3.1390-1395.1996
https://doi.org/10.1128/jvi.70.3.1390-1395.1996
Autor:
Alan Hay, Stephen A. Spector, David W. Kimberlin, Richard J. Whitley, Douglas L. Mayers, Karen K. Biron, Edgar L. Hill
Publikováno v:
Antiviral Research. 26:403-413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5c4da74a4b182d79a5b34373c73f85
https://doi.org/10.1016/0166-3542(95)00028-k
https://doi.org/10.1016/0166-3542(95)00028-k