Výsledky vyhledávání - "K, Biggadike"

Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile

Autor: I J, Uings, D, Needham, J, Matthews, M, Haase, R, Austin, D, Angell, K, Leavens, J, Holt, K, Biggadike, S N, Farrow

Publikováno v: British journal of pharmacology. 169(6)

Glucocorticoids are highly effective therapies for a range of inflammatory diseases. Advances in the understanding of the diverse molecular mechanisms underpinning glucocorticoid action suggest that anti-inflammatory molecules with reduced side effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3dfa5b59b30a27ccc1556767933a9118
https://pubmed.ncbi.nlm.nih.gov/23639214

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ChemInform Abstract: Chiral Carbocyclic Nucleosides: The Synthesis and Antiviral Activity of 4′-Hydroxy- and 4′-Fluorocarbocyclic 2′-Deoxyguanosines

Autor: D. J. Knight, Jonathan A. V. Coates, I. L. Paternoster, K. Biggadike, Alan D. Borthwick

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32ff7636d3f74e72a7ae958dceb70f13
https://doi.org/10.1002/chin.199427247

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X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain

Autor: Eugene L. Stewart, Anne M. Hassell, Iain M. McLay, Randy K. Bledsoe, Lisa M. Shewchuk, Barrie E. Kirk, K. Biggadike

Publikováno v: Journal of medicinal chemistry. 51(12)

An X-ray crystal structure is reported for the novel enhanced-affinity glucocorticoid agonist fluticasone furoate (FF) in the ligand binding domain of the glucocorticoid receptor. Comparison of this structure with those of dexamethasone and fluticaso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884e49e15bf381805b44ef49d0aeeb46
https://pubmed.ncbi.nlm.nih.gov/18522385

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Synthesis of fluorinated carbocyclic nucleosides: preparation of (±)-carbocyclic-FMAU and some congeners

Autor: Les Stephenson, Anne M. Exall, Alexandra M. Z. Slawin, Peter Youds, Barrie E. Kirk, Alan D. Borthwick, Stanley M. Robberts, K. Biggadike, Derek Evans, David J. Williams

Publikováno v: J. Chem. Soc., Chem. Commun.. :251-254

The alcohols (7) and (19) and the ketone (28) were treated with diethylaminosulphur trifluoride (DAST) to give the fluoro-compounds (8), (21), and (29) respectively: compound (8) was converted into the potential anti-viral agents carbocyclic-FMAU (14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3af06388f5e8bc0c265669d10fc4e88
https://doi.org/10.1039/c39870000251

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Synthesis of functionalised cephalosporins

Autor: M.V.J. Ramsay, B. Laundon, D.C. Humber, K. Biggadike, A.G. Long

Publikováno v: Tetrahedron. 41:2025-2031

The N-formamido cephalosporins 4a and 4b undergo direct methoxylation at the Pα-position to give the 7α-methoxy derivatives 5a and 5b . These were converted to other 7β-acylamido compounds by the sequence : oxidation, deformylation, acylation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d69e55b971f9b76249b1ffd84017bc1
https://doi.org/10.1016/s0040-4020(01)96571-8

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ChemInform Abstract: SYNTHESIS OF FUNCTIONALIZED CEPHALOSPORINS. DIPHENYLMETHYL (1S,6R,7S)-3-BROMOMETHYL-7-FORMAMIDO-7-METHOXYCEPH-3-EM-4-CARBOXYLATE 1-OXIDE: A USEFUL INTERMEDIATE IN THE PREPARATION OF 7α-METHOXYCEPHALOSPORINS

Autor: K. BIGGADIKE, D. C. HUMBER, B. LAUNDON, A. G. LONG, M. V. J. RAMSAY

Publikováno v: Chemischer Informationsdienst. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e69e191fc84b319e841e41334b8665cd
https://doi.org/10.1002/chin.198539355

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ChemInform Abstract: Synthesis of Fluorinated Carbocyclic Nucleosides: Preparation of (.+-.)-Carbocyclic-FMAU and Some Congeners

Autor: Barrie E. Kirk, Alan D. Borthwick, Alexandra M. Z. Slawin, David J. Williams, Dennis F. Evans, Les Stephenson, Peter Youds, K. Biggadike, Stanley M. Roberts, Anne M. Exall

Publikováno v: ChemInform. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7b9620f3b2599c07e2f3bec62605951
https://doi.org/10.1002/chin.198733343

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ChemInform Abstract: Use of Diethylaminosulfur Trifluoride (DAST) in the Preparation of Synthons of Carbocyclic Nucleosides

Autor: Dennis F. Evans, Les Stephenson, Alan D. Borthwick, Peter Youds, K. Biggadike, Stanley M. Roberts, Barrie E. Kirk, Anne M. Exall

Publikováno v: ChemInform. 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16998c251ba3b0802c9096e32b51a0b0
https://doi.org/10.1002/chin.198824350

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ChemInform Abstract: Synthesis and Enzymatic Resolution of Carbocyclic 2′-Ara-fluoroguanosine (I): A Potent New Anti-Herpetic Agent

Autor: J. M. Cameron, Peter Youds, Alan D. Borthwick, S. Butt, K. Biggadike, Anne M. Exall, C. L. P. Marr, M. D. Shill, Barrie E. Kirk, B. R. Booth, Stanley M. Roberts, S. W. Cox

Publikováno v: ChemInform. 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::616e0dd71c563dc003a350229457b1a7
https://doi.org/10.1002/chin.198843355

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