Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Jyrki Taskinen"'
Publikováno v:
Drug Metabolism and Disposition. 33:1017-1026
The initial glucuronidation rates were determined for eight recombinant human UDP-glucuronosyltransferases (UGTs) of the 1A subfamily, and the bisubstrate kinetics and inhibition patterns were analyzed. At low substrate concentrations, the reactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538dc8e36682448f3144084555703ff2
https://doi.org/10.1124/dmd.105.004093
https://doi.org/10.1124/dmd.105.004093
Autor:
Jyrki Taskinen, Julius Sipilae
Publikováno v:
Journal of Chemical Information and Computer Sciences. 44:97-104
Three-dimensional QSAR models with different charge calculation methods (MOPAC-AM1-ESP, MOPAC-AM1-Coulson and Gasteiger-Hückel) were developed for predicting all three enzyme kinetic parameters Km, Vmax and Vmax/Km for catecholic substrates of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b339d709cbd16b712633aca84cf23dc1
https://doi.org/10.1021/ci034189k
https://doi.org/10.1021/ci034189k
Autor:
Pia Pihlavisto, Alan M. Hood, Jyrki Taskinen, Michael W.H. Coughtrie, Brian T. Ethell, Brian Burchell
Publikováno v:
ResearcherID
Conjugation of a structurally diverse set of 53 catechol compounds was studied in vitro using six recombinant human sulfotransferases (SULTs), five UDP-glucuronosyltransferases (UGT) and the soluble form of catechol O-methyltransferase (S-COMT) as ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11c4c933c95fff1984b05711064d3f1
https://doi.org/10.1124/dmd.31.9.1187
https://doi.org/10.1124/dmd.31.9.1187
Autor:
Risto Kostiainen, Leena Luukkanen, Jouni Hirvonen, Mika Kurkela, J. Arturo Garcı́a-Horsman, Marc Baumann, Moshe Finel, Saila Mörsky, Jyrki Taskinen
Publikováno v:
Journal of Biological Chemistry. 278:3536-3544
Eight human liver UDP-glucuronosyltransferases (UGTs) were expressed in baculovirus-infected insect cells as fusion proteins carrying a short C-terminal extension that ends with 6 histidine residues (His tag). The activity of recombinant UGT1A1, UGT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec109829075bcb7abb85be2532904088
https://doi.org/10.1074/jbc.m206136200
https://doi.org/10.1074/jbc.m206136200
Autor:
Eivor Elovaara, Jacques Magdalou, Sylvie Fournel-Gigleux, Laurence Antonio, Marie-Helene Piet, Mohamed Ouzzine, Joël-Paul Grillasca, Brian T. Ethell, Jyrki Taskinen, Brian Burchell
Publikováno v:
Drug Metabolism and Disposition. 30:199-207
Catechols are a class of substances from natural or synthetic origin that contain a 1,2-dihydroxybenzene group. We have characterized the glucuronidation by rat liver microsomes and by the rat liver recombinant UDP-glucuronosyltransferase isoforms UG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619b1f1c614c8cb469fe83094cf7d1bb
https://doi.org/10.1124/dmd.30.2.199
https://doi.org/10.1124/dmd.30.2.199
Autor:
Pia Lautala, Mohamed Ouzzine, Katia Monastyrskaia, Brian Burchell, Jyrki Taskinen, Kenneth Lundstrom, Ismo Ulmanen, Tarja Forsman
Publikováno v:
Life Sciences. 67:2473-2484
Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31d63c4c9c6d775662c326d86b6adc1
https://doi.org/10.1016/s0024-3205(00)00831-6
https://doi.org/10.1016/s0024-3205(00)00831-6
Publikováno v:
Tetrahedron Letters. 41:2443-2446
The preparation of 5-substituted 2-carboxyindoles on solid support is reported. In the approach, the indole moiety is synthesized in solution phase, followed by nitro-group reduction, reductive amination and alkylation on solid support. The method pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3183475ce3d740ac3be205602df51390
https://doi.org/10.1016/s0040-4039(00)00151-9
https://doi.org/10.1016/s0040-4039(00)00151-9
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 749:253-263
Direct, quantitative capillary electrophoresis-electrospray ionisation mass spectrometric (CE-ESI-MS) and tandem mass spectrometric (CE-ESI-MS-MS) methods are described for the quantitation of 3-O-glucuronides of E- and Z-entacapone isomers (EEG and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd02e4aa687b12ead3d38a06ddc9682
https://doi.org/10.1016/s0378-4347(00)00413-8
https://doi.org/10.1016/s0378-4347(00)00413-8
Autor:
Sandeep Modi, Gary R. Manchee, Anne Hersey, Robert M. Cooke, Harren Jhoti, Anne Cleasby, Margarete Neu, Alan J. Wonacott, Alan M. Hood, Jyrki Taskinen, Michael W.H. Coughtrie, Rana Dajani
Publikováno v:
Journal of Biological Chemistry. 274:37862-37868
Humans are one of the few species that produce large amounts of catecholamine sulfates, and they have evolved a specific sulfotransferase, SULT1A3 (M-PST), to catalyze the formation of these conjugates. An orthologous protein has yet to be found in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8eff0b594c5663fd3200c73d6fced88
https://doi.org/10.1074/jbc.274.53.37862
https://doi.org/10.1074/jbc.274.53.37862
Publikováno v:
Rapid Communications in Mass Spectrometry. 13:1680-1684
Tandem mass spectrometric behaviour was studied for a small combinatorial library of alkyl 3-hydroxy-5-(4′-nitrophenoxy) benzoates (A1–A5) and alkyl 3-hydroxy-5-(2′, 4′-dinitrophenoxy) benzoates (B1–B5). The spectra were recorded by negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5bcf500850f705dccc5c9dc982fb6a
https://doi.org/10.1002/(sici)1097-0231(19990830)13:16<1680::aid-rcm698>3.0.co
https://doi.org/10.1002/(sici)1097-0231(19990830)13:16<1680::aid-rcm698>3.0.co