Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity.

Autor: Ainoleena Turku, Maiju K Rinne, Gustav Boije Af Gennäs, Henri Xhaard, Dan Lindholm, Jyrki P Kukkonen

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178526 (2017)

Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties. One of them, 1-(3,4-dichlorophenyl)-2-[2-imino-3-(4-methylbenzyl)-2,3-dihydro-1H-benzo[d]imi

Externí odkaz: https://doaj.org/article/d9d6d479432e4f74a00380e93b4b81dc

The G protein preference of orexin receptors is currently an unresolved issue

Autor: Jyrki P. Kukkonen

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)

Externí odkaz: https://doaj.org/article/719fddcabb9047b09cd61cc7f040e535

No evidence of autoimmunity to human OX1 or OX2 orexin receptors in Pandemrix-vaccinated narcoleptic children

Autor: Krister Melén, Pinja Jalkanen, Jyrki P. Kukkonen, Markku Partinen, Hanna Nohynek, Arja Vuorela, Outi Vaarala, Tobias L. Freitag, Seppo Meri, Ilkka Julkunen

Publikováno v: Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100055- (2020)

Narcolepsy type 1, likely an immune-mediated disease, is characterized by excessive daytime sleepiness and cataplexy. The disease is strongly associated with human leukocyte antigen (HLA) DQB1∗06:02. A significant increase in the incidence of child

Externí odkaz: https://doaj.org/article/f3009f34c6144c4e93177ff51a7b65dc

Measurement of orexin levels is currently an uncertain business

Autor: Jyrki P. Kukkonen

Publikováno v: Sleep Medicine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a5eecad346981b56cfe9c132146397c
https://doi.org/10.1016/j.sleep.2023.05.022

The Concise Guide To Pharmacology 2021/22: G Protein-Coupled Receptors

Autor: Nigel J. M. Birdsall, Stephen J Lolait, Hans-Jürgen Wester, Paul L. Chazot, Sadashiva S. Karnik, Simon D. Harding, Celine Valant, Stephen P.H. Alexander, Olivier Civelli, Zsolt Csaba, Mastgugu Horiuchi, Khuraijam Dhanachandra Singh, Theodore L. Goodfriend, Morley D. Hollenberg, Duuamene Nyimanu, Shlomo Melmed, G. Enrico Rovati, Xavier Norel, Leigh A. Stoddart, Klemens Kaupmann, Robyn Macrae, Nicholas D. Holliday, Deborah L. Segaloff, Justo P. Castaño, Tony Ngo, Gordon Dent, Jean-Martin Beaulieu, Thomas L Williams, Antonia Cianciulli, Paweł Kozielewicz, Xaria X. Li, Jyrki P. Kukkonen, Craig A. McArdle, John D. Lee, Philippe Rondard, Steven D. Douglas, Hubert Vaudry, Khaled A. Al-Hosaini, Nan Chiang, Bernhard Bettler, Giovanni Tulipano, Corinne Bousquet, Karen J. Gregory, Craig Gerard, Robert T. Jensen, Stefan Schulz, Rithwik Ramachandran, Ross A. D. Bathgate, Deepa Jonnalagadda, David M. Thal, Takio Kitazawa, Manisha Ray, Bice Chini, Thomas Unger, Marta Fumagalli, Jean-Pierre Vilardaga, Donald T. Ward, Roger G. Pertwee, Stefan Offermanns, Marvin C. Gershengorn, Marc Parmentier, Pieter Timmermans, Eamonn Kelly, Yukihiko Sugimoto, Hamiyet Unal, Vincenzo Mitolo, Alistair Mathie, Emma L. Veale, Andrew L. Gundlach, Anthony P. Davenport, Mark T. Quinn, Jérôme Leprince, Christa E. Müller, Geoffrey Burnstock, Akos Heinemann, Jacqueline R. Kemp, Richard D. Ye, Bernard Mouillac, Roger J. Summers, Raul R. Gainetdinov, Girolamo Calò, Philip N. Murphy, Amelie Lupp, Kalyan C. Tirupula, Walter G. Thomas, Julien Hanson, Ahsan Husain, Katie Leach, Lucie H. Clapp, Hans Bräuner-Osborne, Gunnar Schulte, Kenneth E. Bernstein, Jean Mazella, Torsten Schöneberg, Satoru Eguchi, Martin C. Michel, Maria Antonietta Panaro, Kevin J. Catt, Rainer K. Reinscheid, Hans-Jürgen Kreienkamp, Wayne R. Alexander, Emanuel Escher, Anne Marie O'Carroll, Magnus Bäck, Laurence J. Miller, Jane F. Armstrong, Chiara Ruzza, Trent M. Woodruff, Daniel Hoyer, Chengcan Yao, Maria P. Abbracchio, John A. Peters, Gary B. Willars, Jean-Philippe Pin, David Vaudry, Debbie L. Hay, François Boulay, Davide Lecca, Eric R. Prossnitz, Arthur Christopoulos, Victoria A. Blaho, Yasuyuki Kihara, Charles Kennedy, Christopher Southan, László Hunyady, Pascal Dournaud, Fernand Gobeil, Cyril Goudet, Charles N. Serhan, Claes Dahlgren, Jörg Hamann, Tobias Langenhan, Ralf Jockers, Nicholas M. Barnes, Jean-Louis Nahon, Richard L. Hauger, Adam J. Pawson, Gareth J. Sanger, Tung Fong, Susan E. Leeman, Elena Faccenda, Edward J. Filardo, Valerie P. Tan, Marc de Gasparo, Ji Ming Wang, Jamie A. Davies, Jerold Chun, Stefania Ceruti, Tadashi Inagami, Réjean Couture, Kenneth A. Jacobson, Patrick Vanderheyden, Adriaan P. IJzerman, Janet J. Maguire, Christopher S. Walker

Publikováno v: British Journal of Pharmacology, 178, S27-S156. Wiley
Alexander, S P, Christopoulos, A, Davenport, A P, Kelly, E, Mathie, A, Peters, J A, Veale, E L, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Abbracchio, M P, Alexander, W, Al-Hosaini, K, Bäck, M, Barnes, N M, Bathgate, R, Beaulieu, J-M, Bernstein, K E, Bettler, B, Birdsall, N J M, Blaho, V, Boulay, F, Bousquet, C, Bräuner-Osborne, H, Burnstock, G, Caló, G, Castaño, J P, Catt, K J, Ceruti, S, Chazot, P, Chiang, N, Chini, B, Chun, J, Cianciulli, A, Civelli, O, Clapp, L H, Couture, R, Csaba, Z, Dahlgren, C, Dent, G, Singh, K D, Douglas, S D, Dournaud, P, Eguchi, S, Escher, E, Filardo, E J, Fong, T, Fumagalli, M, Gainetdinov, R R, Gasparo, M D, Gerard, C, Gershengorn, M, Gobeil, F, Goodfriend, T L, Goudet, C, Gregory, K J, Gundlach, A L, Hamann, J, Hanson, J, Hauger, R L, Hay, D L, Heinemann, A, Hollenberg, M D, Holliday, N D, Horiuchi, M, Hoyer, D, Hunyady, L, Husain, A, IJzerman, A P, Inagami, T, Jacobson, K A, Jensen, R T, Jockers, R, Jonnalagadda, D, Karnik, S, Kaupmann, K, Kemp, J, Kennedy, C, Kihara, Y, Kitazawa, T, Kozielewicz, P, Kreienkamp, H-J, Kukkonen, J P, Langenhan, T, Leach, K, Lecca, D, Lee, J D, Leeman, S E, Leprince, J, Li, X X, Williams, T L, Lolait, S J, Lupp, A, Macrae, R, Maguire, J, Mazella, J, McArdle, C A, Melmed, S, Michel, M C, Miller, L J, Mitolo, V, Mouillac, B, Müller, C E, Murphy, P, Nahon, J-L, Ngo, T, Norel, X, Nyimanu, D, O'Carroll, A-M, Offermanns, S, Panaro, M A, Parmentier, M, Pertwee, R G, Pin, J-P, Prossnitz, E R, Quinn, M, Ramachandran, R, Ray, M, Reinscheid, R K, Rondard, P, Rovati, G E, Ruzza, C, Sanger, G J, Schöneberg, T, Schulte, G, Schulz, S, Segaloff, D L, Serhan, C N, Stoddart, L A, Sugimoto, Y, Summers, R, Tan, V P, Thal, D, Thomas, W W, Timmermans, P B M W M, Tirupula, K, Tulipano, G, Unal, H, Unger, T, Valant, C, Vanderheyden, P, Vaudry, D, Vaudry, H, Vilardaga, J-P, Walker, C S, Wang, J M, Ward, D T, Wester, H-J, Willars, G B, Woodruff, T M, Yao, C & Ye, R D 2021, ' THE CONCISE GUIDE TO PHARMACOLOGY 2021/22 : G protein-coupled receptors ', British Journal of Pharmacology, vol. 178 Suppl 1, no. S1, pp. S27-S156 . https://doi.org/10.1111/bph.15538
British journal of pharmacology, 178(S1), S27-S156. Wiley-Blackwell
Alexander, S P, Christopoulos, A, Davenport, A P, Kelly, E, Mathie, A, Peters, J A, Veale, E L, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Abbracchio, M P, Alexander, W, Al-Hosaini, K, Bäck, M, Barnes, N M, Bathgate, R, Beaulieu, J-M, Bernstein, K E, Bettler, B, Birdsall, N J M, Blaho, V, Boulay, F, Bousquet, C, Bräuner-Osborne, H, Burnstock, G, Caló, G, Castaño, J P, Catt, K J, Ceruti, S, Chazot, P, Chiang, N, Chini, B, Chun, J, Cianciulli, A, Civelli, O, Clapp, L H, Couture, R, Csaba, Z, Dahlgren, C, Dent, G, Singh, K D, Douglas, S D, Dournaud, P, Eguchi, S, Escher, E, Filardo, E J, Fong, T, Fumagalli, M, Gainetdinov, R R, Gasparo, M D, Gerard, C, Gershengorn, M, Gobeil, F, Goodfriend, T L, Goudet, C, Gregory, K J, Gundlach, A L, Hamann, J, Hanson, J, Hauger, R L, Hay, D L, Heinemann, A, Hollenberg, M D, Holliday, N D, Horiuchi, M, Hoyer, D, Hunyady, L, Husain, A, IJzerman, A P, Inagami, T, Jacobson, K A, Jensen, R T, Jockers, R, Jonnalagadda, D, Karnik, S, Kaupmann, K, Kemp, J, Kennedy, C, Kihara, Y, Kitazawa, T, Kozielewicz, P, Kreienkamp, H-J, Kukkonen, J P, Langenhan, T, Leach, K, Lecca, D, Lee, J D, Leeman, S E, Leprince, J, Li, X X, Williams, T L, Lolait, S J, Lupp, A, Macrae, R, Maguire, J, Mazella, J, McArdle, C A, Melmed, S, Michel, M C, Miller, L J, Mitolo, V, Mouillac, B, Müller, C E, Murphy, P, Nahon, J-L, Ngo, T, Norel, X, Nyimanu, D, O'Carroll, A-M, Offermanns, S, Panaro, M A, Parmentier, M, Pertwee, R G, Pin, J-P, Prossnitz, E R, Quinn, M, Ramachandran, R, Ray, M, Reinscheid, R K, Rondard, P, Rovati, G E, Ruzza, C, Sanger, G J, Schöneberg, T, Schulte, G, Schulz, S, Segaloff, D L, Serhan, C N, Stoddart, L A, Sugimoto, Y, Summers, R, Tan, V P, Thal, D, Thomas, W W, Timmermans, P B M W M, Tirupula, K, Tulipano, G, Unal, H, Unger, T, Valant, C, Vanderheyden, P, Vaudry, D, Vaudry, H, Vilardaga, J-P, Walker, C S, Wang, J M, Ward, D T, Wester, H-J, Willars, G B, Woodruff, T M, Yao, C & Ye, R D 2021, ' THE CONCISE GUIDE TO PHARMACOLOGY 2021/22 : G protein-coupled receptors ', British Journal of Pharmacology, vol. 178, no. S1, pp. S27-S156 . https://doi.org/10.1111/bph.15538

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef5f3d1320e3d9fb87604fe0e7987c5
https://cris.maastrichtuniversity.nl/en/publications/e6053af4-7c66-44a3-97bc-f7b87d1745a9