Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jyrki, Lehtimäki"'
Publikováno v:
The Journal of Sexual Medicine. 18:1677-1689
Background Premature ejaculation is the most common sexual dysfunction in young men, and it often leads to reduced relationship satisfaction and quality of life. Aim To determine the role of central and peripheral α2-adrenoceptors in the control of
Autor:
Jyrki, Lehtimäki, Niina, Jalava, Kaisa, Unkila, John, Aspegren, Antti, Haapalinna, Ullamari, Pesonen
Publikováno v:
European journal of pharmacology. 923
The pharmacological profile of tasipimidine, a novel orally active α
Autor:
Minja Hyttila-Hopponen, Jyrki Lehtimäki, Tarja Kuosmanen, Joost F M Lensen, Tiina Leino, Stefan Karlsson
Publikováno v:
Toxicologic pathology. 49(7)
Intracellular inclusions were observed in urinary bladder epithelium of male Wistar rats, following oral treatment with high doses of the α2A-adrenoceptor agonist tasipimidine for 28 days. No cell death or inflammation was associated with the bright
Tasipimidine—the pharmacological profile of a novel orally active selective α2A-adrenoceptor agonist
Autor:
Jyrki Lehtimäki, Niina Jalava, Kaisa Unkila, John Aspegren, Antti Haapalinna, Ullamari Pesonen
Publikováno v:
European Journal of Pharmacology. 923:174949
Publikováno v:
The journal of sexual medicine. 18(10)
Premature ejaculation is the most common sexual dysfunction in young men, and it often leads to reduced relationship satisfaction and quality of life.To determine the role of central and peripheral αSexual incentive motivation was studied in a large
Publikováno v:
European journal of pharmacology. 882
Fadolmidine is an α2-adrenoceptor full agonist developed for spinal analgesia with a local mode of action. The purpose of this study was to demonstrate the safety of fadolmidine on known α2-adrenoceptor-related effects: kidney function, urodynamics
Autor:
Jelena Mijatovic, Petteri Piepponen, Katja Kuokkanen, Heikki Tanila, Johanna Holappa, Jukka Sallinen, Raimo Virtanen, Jouni Sirviö, Hugh Chapman, Antti Haapalinna, Ari Koivisto, Jyrki Lehtimäki
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 113:239-249
The α2-adrenoceptors (ARs) are important modulators of a wide array of physiological responses. As only a few selective compounds for the three α2-AR subtypes (α2A , α2B and α2C ) have been available, the pharmacological profile of a new α2C-se
Publikováno v:
Pharmacology Biochemistry and Behavior. 103:345-352
Premature ejaculation is the most common sexual disorder in young men. Consequently, there is an intense search for efficient and safe pharmacological treatments. Insofar, almost no effective treatment with acute effects is available. In this study,
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 380:539-550
The present experiments compared the peripheral and central pharmacological effects of three alpha(2)-adrenoceptor agonists: fadolmidine, clonidine, and dexmedetomidine after single intrathecal bolus injections at analgesic dose level in rats. Effect
Autor:
Ari Koivisto, Raimo Virtanen, Tiina Leino, Tarja Lehtimäki, Katja Kuokkanen, Antti Haapalinna, Jyrki Lehtimäki, Timo Viitamaa
Publikováno v:
European Journal of Pharmacology. 599:65-71
Alpha2-adrenergic receptors (alpha2-adrenoceptors) mediate various physiological actions of endogenous catecholamines in the central and peripheral nervous systems being involved in alertness, heart rate regulation, vasomotor control and nociceptive