Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Jyrki, Heino"'
Autor:
Zihan Xia, Stephanie Vermeulen, Ujjwal Suwal, Pekka Rappu, Jyrki Heino, Felix De Vuyst, Sandor Dedeyne, An Hendrix, Hannelore Denys, Olivier De Wever
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/c08971295d3049dcbe317f98cac8c015
Autor:
Salli Talvi, Johanna Jokinen, Kalle Sipilä, Pekka Rappu, Fu-Ping Zhang, Matti Poutanen, Pia Rantakari, Jyrki Heino
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108914- (2024)
Summary: Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone marrow. Here, we show that embigin expression is at high level during ear
Externí odkaz:
https://doaj.org/article/d136b79b5d374405a192181d8e634d5d
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (EC
Externí odkaz:
https://doaj.org/article/db096414230048f187091d3ab6166f56
Autor:
Richard Farndale, Arnoud Sonnenberg, C. Michael DiPersio, Johannes A Eble, Jyrki Heino, Donald Gullberg
Publikováno v:
Matrix Biology. 115:128-132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0e0e82c01bbf6921f974a1ba124822
https://doi.org/10.1016/j.matbio.2022.12.004
https://doi.org/10.1016/j.matbio.2022.12.004
Autor:
Bert Dhondt, Edward Geeurickx, Joeri Tulkens, Jan Van Deun, Glenn Vergauwen, Lien Lippens, Ilkka Miinalainen, Pekka Rappu, Jyrki Heino, Piet Ost, Nicolaas Lumen, Olivier De Wever, An Hendrix
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Extracellular vesicles (EV) are increasingly being recognized as important vehicles of intercellular communication and promising diagnostic and prognostic biomarkers in cancer. Despite this enormous clinical potential, the plethora of methods to sepa
Externí odkaz:
https://doaj.org/article/193086442b6948d7aff7333ad45c415a
Autor:
Kalle H. Sipilä, Vipin Ranga, Pekka Rappu, Markku Mali, Laura Pirilä, Ilona Heino, Johanna Jokinen, Jarmo Käpylä, Mark S. Johnson, Jyrki Heino
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract We report the extent, specific sites and structural requirements of joint inflammation related citrullination in extracellular proteins. A total of 40 synovial fluid samples derived from chronically inflamed human joints were analysed by hep
Externí odkaz:
https://doaj.org/article/1499297be840416aa311dd65cde115bb
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large ligands, such as human
Externí odkaz:
https://doaj.org/article/dbf99cfe587e47e9a99e9658e71ebd1f
Autor:
Carlos J Diaz Osterman, Duygu Ozmadenci, Elizabeth G Kleinschmidt, Kristin N Taylor, Allison M Barrie, Shulin Jiang, Lisa M Bean, Florian J Sulzmaier, Christine Jean, Isabelle Tancioni, Kristen Anderson, Sean Uryu, Edward A Cordasco, Jian Li, Xiao Lei Chen, Guo Fu, Marjaana Ojalill, Pekka Rappu, Jyrki Heino, Adam M Mark, Guorong Xu, Kathleen M Fisch, Vihren N Kolev, David T Weaver, Jonathan A Pachter, Balázs Győrffy, Michael T McHale, Denise C Connolly, Alfredo Molinolo, Dwayne G Stupack, David D Schlaepfer
Publikováno v:
eLife, Vol 8 (2019)
Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities,
Externí odkaz:
https://doaj.org/article/7193db572cdc40948c8a07915a6afd96
Autor:
Jan Van Deun, Quentin Roux, Sarah Deville, Thibaut Van Acker, Pekka Rappu, Ilkka Miinalainen, Jyrki Heino, Frank Vanhaecke, Bruno G. De Geest, Olivier De Wever, An Hendrix
Publikováno v:
Cells, Vol 9, Iss 8, p 1797 (2020)
Biomimetic functionalization to confer stealth and targeting properties to nanoparticles is a field of intense study. Extracellular vesicles (EV), sub-micron delivery vehicles for intercellular communication, have unique characteristics for drug deli
Externí odkaz:
https://doaj.org/article/7954e922a9234bacbf83d6b8935b1207
Publikováno v:
Biology Open, Vol 7, Iss 11 (2018)
Long non-coding RNAs (lncRNAs) regulate various cellular processes, and they have emerged as potential biomarkers and therapeutic targets in cancer. We have previously characterized the oncogenic role of lncRNA PICSAR (p38 inhibited cutaneous squamou
Externí odkaz:
https://doaj.org/article/1ac8b8a7ab774ce9ac81ad7bceaf4743