Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jyotsna U. Rao"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
Abstract Gliomas maintain an acidic extracellular pH (pHe), which promotes tumor growth and builds resistance to therapy. Given evidence that acidic pHe beyond the tumor core indicates infiltration, we hypothesized that imaging the intratumoral pHe i
Externí odkaz:
https://doaj.org/article/9101447783b94692a1bde5eeeb7ffa36
Autor:
Henri J.L.M. Timmers, Fred C.G.J. Sweep, Henricus P.M. Kunst, Arjen R. Mensenkamp, Ad R.M.M. Hermus, Jacques W.M. Lenders, Angelina G. Goudswaard, Benno Kusters, Nan Qin, Graeme Eisenhofer, Karel Pacak, Ron A. Wevers, Richard J.T. Rodenburg, Udo F.H. Engelke, Jyotsna U. Rao
Supplementary Figure 1 Examples of 1H NMR spectra for different genotypes A. Example of NMR spectrum of a sporadic tumor depicting the peak positions of lactic acid, acetic acid and catecholamines. B. Example of NMR spectrum of a SDHB tumor depicting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b4e7f36498fde85425c773f15e2f0a
https://doi.org/10.1158/1078-0432.22447437.v1
https://doi.org/10.1158/1078-0432.22447437.v1
Autor:
Henri J.L.M. Timmers, Fred C.G.J. Sweep, Henricus P.M. Kunst, Arjen R. Mensenkamp, Ad R.M.M. Hermus, Jacques W.M. Lenders, Angelina G. Goudswaard, Benno Kusters, Nan Qin, Graeme Eisenhofer, Karel Pacak, Ron A. Wevers, Richard J.T. Rodenburg, Udo F.H. Engelke, Jyotsna U. Rao
Supplementary legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b6ff919beca05025dd012afd308857
https://doi.org/10.1158/1078-0432.22447434
https://doi.org/10.1158/1078-0432.22447434
Autor:
Henri J.L.M. Timmers, Fred C.G.J. Sweep, Henricus P.M. Kunst, Arjen R. Mensenkamp, Ad R.M.M. Hermus, Jacques W.M. Lenders, Angelina G. Goudswaard, Benno Kusters, Nan Qin, Graeme Eisenhofer, Karel Pacak, Ron A. Wevers, Richard J.T. Rodenburg, Udo F.H. Engelke, Jyotsna U. Rao
Purpose: Pheochromocytomas and paragangliomas (PGL) are neuroendocrine tumors of sympathetic and parasympathetic paraganglia. This study investigated the relationships between genotype-specific differences in mitochondrial function and catecholamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210db00b089c299d37bc60772e7448cc
https://doi.org/10.1158/1078-0432.c.6521073
https://doi.org/10.1158/1078-0432.c.6521073
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
Scientific Reports
Scientific Reports
Gliomas maintain an acidic extracellular pH (pHe), which promotes tumor growth and builds resistance to therapy. Given evidence that acidic pHe beyond the tumor core indicates infiltration, we hypothesized that imaging the intratumoral pHe in relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef93cc303014a61f865e4ac5e30713c
https://doaj.org/article/9101447783b94692a1bde5eeeb7ffa36
https://doaj.org/article/9101447783b94692a1bde5eeeb7ffa36
Autor:
Lihong Jiang, Gen Kaneko, Jane R. Taylor, Basavaraju G. Sanganahalli, Helen Wang, Katherine M. Rich, Jyotsna U. Rao, Robin A. de Graaf, Stephanie M. Groman, Fahmeed Hyder, Peter Herman, Daniel Coman
Publikováno v:
Biological Psychiatry. 81:503-513
Background Schizophrenia is a debilitating neuropsychiatric disorder typically diagnosed from late adolescence to adulthood. Subthreshold behavioral symptoms (e.g., cognitive deficits and substance abuse) often precede the clinical diagnosis of schiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fee2db7207f926cc5de31ae9093517f
https://doi.org/10.1016/j.biopsych.2016.05.019
https://doi.org/10.1016/j.biopsych.2016.05.019
Autor:
Maria Fala, Richard Mair, Anastasia Tsyben, Katherine Gibson, Jyotsna U. Rao, Kevin M. Brindle, Alan J. Wright, Richard J. A. Goodwin, Gregory Hamm
Publikováno v:
Neuro Oncol
INTRODUCTION. Glioblastoma multiforme (GBM) has a dismal prognosis, which has been attributed to extensive inter- and intra-tumoural heterogeneity. To investigate the metabolic heterogeneity of GBM, we employed desorption electrospray ionization (DES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d909ada4d9c485d07788fa70e6b8127
https://europepmc.org/articles/PMC6847263/
https://europepmc.org/articles/PMC6847263/
Publikováno v:
NMR in Biomedicine. 29:1364-1372
Biosensor imaging of redundant deviation in shifts (BIRDS), an ultrafast chemical shift imaging technique, requires infusion of paramagnetic probes such as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis methylene phosphonate (DOTP(8-) ) complexed w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56006c3e4d7fa31869322f03577234c0
https://doi.org/10.1002/nbm.3578
https://doi.org/10.1002/nbm.3578
Autor:
Lester R. Drewes, Fahmeed Hyder, Kevin L. Behar, Jean Francois H. Geschwind, Jyotsna U. Rao, Douglas L. Rothman, Kirby Madden-Hennessey, Kevan Ip, Henk M. De Feyter, Robin A. de Graaf
Publikováno v:
Neuro-Oncology. 18:1079-1087
Background The dependence of tumor cells, particularly those originating in the brain, on glucose is the target of the ketogenic diet, which creates a plasma nutrient profile similar to fasting: increased levels of ketone bodies and reduced plasma gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0dda0a3099ff2885ab95374dee8c23f
https://doi.org/10.1093/neuonc/now088
https://doi.org/10.1093/neuonc/now088
Autor:
Christoph Juchem, Henk M. De Feyter, Douglas L. Rothman, Yuegao Huang, Jyotsna U. Rao, Daniel Coman, Fahmeed Hyder
Publikováno v:
NMR in Biomedicine. 29:309-319
Solid tumors have an acidic extracellular pH (pHe ) but near neutral intracellular pH (pHi ). Because acidic pHe milieu is conducive to tumor growth and builds resistance to therapy, simultaneous mapping of pHe inside and outside the tumor (i.e., int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68b50ebb691d3dd4fcd0191c991c5985
https://doi.org/10.1002/nbm.3466
https://doi.org/10.1002/nbm.3466