Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jyotika Varshney"'
Autor:
Victor Antontsev, Aditya Jagarapu, Yogesh Bundey, Hypatia Hou, Maksim Khotimchenko, Jason Walsh, Jyotika Varshney
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution a
Externí odkaz:
https://doaj.org/article/5e7fa5ef5904452a887724f1bb44840c
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 594 (2021)
Fluoroquinolones (FQs) are a widespread class of broad-spectrum antibiotics prescribed as a first line of defense, and, in some cases, as the only treatment against bacterial infection. However, when administered orally, reduced absorption and bioava
Externí odkaz:
https://doaj.org/article/439579b7fc484e069b89232e7d01baab
Autor:
Kaushik Chakravarty, Victor G. Antontsev, Maksim Khotimchenko, Nilesh Gupta, Aditya Jagarapu, Yogesh Bundey, Hypatia Hou, Neha Maharao, Jyotika Varshney
Publikováno v:
Molecules, Vol 26, Iss 7, p 1912 (2021)
The COVID-19 pandemic has reached over 100 million worldwide. Due to the multi-targeted nature of the virus, it is clear that drugs providing anti-COVID-19 effects need to be developed at an accelerated rate, and a combinatorial approach may stand to
Externí odkaz:
https://doaj.org/article/fa828343863b4c448ca76ad350be4eaa
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 284 (2021)
The use of opioid analgesics in treating severe pain is frequently associated with putative adverse effects in humans. Topical agents that are shown to have high efficacy with a favorable safety profile in clinical settings are great alternatives for
Externí odkaz:
https://doaj.org/article/38f8715ebd6348d2b5db3f4da14380c4
Autor:
Daniel M. Walden, Yogesh Bundey, Aditya Jagarapu, Victor Antontsev, Kaushik Chakravarty, Jyotika Varshney
Publikováno v:
Molecules, Vol 26, Iss 1, p 182 (2021)
Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API solubility with various carriers in the API–carrier mixture and the principa
Externí odkaz:
https://doaj.org/article/284e4016118a446da0839634845c15a7
Publikováno v:
Veterinary Sciences, Vol 3, Iss 1, p 3 (2016)
Osteosarcoma is an aggressive primary bone tumor in humans and is among the most common cancer afflicting dogs. Despite surgical advancements and intensification of chemo- and targeted therapies, the survival outcome for osteosarcoma patients is, as
Externí odkaz:
https://doaj.org/article/cec8ce77f9e044608d21740110630c62
Autor:
Aaron L. Sarver, Subbaya Subramanian, Jaime F. Modiano, David A. Largaespada, Logan G. Spector, Timothy D. O'Brien, Branden S. Moriarity, Natalie K. Wolf, Jyotika Varshney, Susan K. Rathe, Rebecca S. LaRue, Anne E. Sarver, Nuri A. Temiz, Milcah C. Scott
Supplemental Table 4. Gene lists identified in the clustering. Tab 1 Genes in Human clusters (n=7), mouse clusters (n=11), dog clusters (n=5), GSE212257 (n=14) Tab 2 Overlap counts of RNASEQ cluster lists. Tab 3 Overlap of human cluster 1 and human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6ac347fe5933328a8c86e312901e86
https://doi.org/10.1158/0008-5472.22417361.v1
https://doi.org/10.1158/0008-5472.22417361.v1
Autor:
Aaron L. Sarver, Subbaya Subramanian, Jaime F. Modiano, David A. Largaespada, Logan G. Spector, Timothy D. O'Brien, Branden S. Moriarity, Natalie K. Wolf, Jyotika Varshney, Susan K. Rathe, Rebecca S. LaRue, Anne E. Sarver, Nuri A. Temiz, Milcah C. Scott
Supplemental Table 6. Gene Cluster Expression Summary Scores. Tab 1 Human GCESS values Tab 2 Mouse GCESS values Tab 3 Dog GCESS values Tab 4 GSE212257 GCESS values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83be76ee4053f2797af54bda0a198a03
https://doi.org/10.1158/0008-5472.22417355
https://doi.org/10.1158/0008-5472.22417355
Autor:
Aaron L. Sarver, Subbaya Subramanian, Jaime F. Modiano, David A. Largaespada, Logan G. Spector, Timothy D. O'Brien, Branden S. Moriarity, Natalie K. Wolf, Jyotika Varshney, Susan K. Rathe, Rebecca S. LaRue, Anne E. Sarver, Nuri A. Temiz, Milcah C. Scott
Read Counts, mapping percentage and expressed gene count for all RNAseq samples. Tab 1 Human Tab 2 Dog Tab 3 Mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0f0149af7e6fdd4e43279f93adf1b8
https://doi.org/10.1158/0008-5472.22417364
https://doi.org/10.1158/0008-5472.22417364
Autor:
Aaron L. Sarver, Subbaya Subramanian, Jaime F. Modiano, David A. Largaespada, Logan G. Spector, Timothy D. O'Brien, Branden S. Moriarity, Natalie K. Wolf, Jyotika Varshney, Susan K. Rathe, Rebecca S. LaRue, Anne E. Sarver, Nuri A. Temiz, Milcah C. Scott
Supplementary methods contains additional information describing methods used and description of all supplemental data included. Supplemental Figures Supplemental Figure 1. Real human data clustered Supplemental Figure 2. Random human data clustered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c097dee86316a8f3ef1e4edd23e780
https://doi.org/10.1158/0008-5472.22417349
https://doi.org/10.1158/0008-5472.22417349