Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jyoti R. Misra"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The paralogous oncogenic transcriptional coactivators YAP and TAZ are the distal effectors of the Hippo signaling pathway, which plays a critical role in cell proliferation, survival and cell fate specification. They are frequently deregulated in mos
Externí odkaz:
https://doaj.org/article/1d6482387d174a3f8c9e7eefcb9ca425
Autor:
Artem Gridnev, Jyoti R. Misra
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Dachsous (Ds) and Fat are evolutionarily conserved cell adhesion molecules that play a critical role in development of multiple organ systems, where they coordinate tissue growth and morphogenesis. Much of our understanding of Ds-Fat signaling pathwa
Externí odkaz:
https://doaj.org/article/c250806d6a1842869a7d2e33a3b18314
Publikováno v:
Cancers, Vol 14, Iss 4, p 1029 (2022)
YAP/TAZ are transcriptional coactivators that function as the key downstream effectors of Hippo signaling. They are commonly misregulated in most human cancers, which exhibit a higher level of expression and nuclear localization of YAP/TAZ, and displ
Externí odkaz:
https://doaj.org/article/67fe41626e2d4a51bc8e65db8dafe898
Autor:
Artem Gridnev, Jyoti R. Misra
Publikováno v:
Frontiers in cell and developmental biology. 10
Dachsous (Ds) and Fat are evolutionarily conserved cell adhesion molecules that play a critical role in development of multiple organ systems, where they coordinate tissue growth and morphogenesis. Much of our understanding of Ds-Fat signaling pathwa
Autor:
Kenneth D. Irvine, Jyoti R. Misra
Publikováno v:
Developmental Cell. 39:254-266
Summary The protocadherins Dachsous and Fat initiate a signaling pathway that controls growth and planar cell polarity by regulating the membrane localization of the atypical myosin Dachs. How Dachs is regulated by Fat signaling has remained unclear.
Autor:
Kenneth D. Irvine, Jyoti R. Misra
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007955 (2019)
PLoS Genetics
PLoS Genetics
The Drosophila protocadherins Dachsous and Fat regulate growth and tissue polarity by modulating the levels, membrane localization and polarity of the atypical myosin Dachs. Localization to the apical junctional membrane is critical for Dachs functio
Autor:
Kenneth D. Irvine, Jyoti R. Misra
Hippo signaling is an evolutionarily conserved network that has a central role in regulating cell proliferation and cell fate to control organ growth and regeneration. It promotes activation of the LATS kinases, which control gene expression by inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4648ffc073f4cce1d2d2a8a6db6a54
https://europepmc.org/articles/PMC6322405/
https://europepmc.org/articles/PMC6322405/
Publikováno v:
Insect Biochemistry and Molecular Biology. 43:1116-1124
Pesticide resistance poses a major challenge for the control of vector-borne human diseases and agricultural crop protection. Although a number of studies have defined how mutations in specific target proteins can lead to insecticide resistance, much
Publikováno v:
Biophysical Chemistry. 137:13-18
The GTPase effector domain (GED) of dynamin forms large soluble oligomers in vitro, while its mutant--I697A--lacks this property at low concentrations. With a view to understand the intrinsic structural characteristics of the polypeptide chain, the g
Publikováno v:
Genesdevelopment. 25(17)
Living organisms, from bacteria to humans, display a coordinated transcriptional response to xenobiotic exposure, inducing enzymes and transporters that facilitate detoxification. Several transcription factors have been identified in vertebrates that