Steroidogenic control of liver metabolism through a nuclear receptor-network

Autor: Alexandra Milona, Vittoria Massafra, Harmjan Vos, Jyoti Naik, Natalia Artigas, Helen A.B. Paterson, Ingrid T.G.W. Bijsmans, Ellen C.L. Willemsen, Jose M. Ramos Pittol, Irene Miguel-Aliaga, Piter Bosma, Boudewijn M.T. Burgering, Catherine Williamson, Santiago Vernia, Waljit S. Dhillo, Saskia W.C. van Mil, Bryn M. Owen

Publikováno v: Molecular Metabolism, Vol 30, Iss , Pp 221-229 (2019)

Objective: Coupling metabolic and reproductive pathways is essential for the survival of species. However, the functions of steroidogenic enzymes expressed in metabolic tissues are largely unknown. Methods and results: Here, we show that in the liver

Externí odkaz: https://doaj.org/article/f03fe7de90804886b4db2443d1f7e1c8

CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia

Autor: Jyoti Naik, Maria Themeli, Regina de Jong-Korlaar, Ruud W.J. Ruiter, Pino J Poddighe, Huipin Yuan, Joost D. de Bruijn, Gert J. Ossenkoppele, Sonja Zweegman, Linda Smit, Tuna Mutis, Anton C.M. Martens, Niels W.C.J. van de Donk, Richard W.J. Groen

Publikováno v: Haematologica, Vol 104, Iss 3 (2019)

Externí odkaz: https://doaj.org/article/89ff26f4897c498783e18e45ab598f0c

Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Autor: Afroditi Katsarou, Maria Sjöstrand, Jyoti Naik, Jorge Mansilla-Soto, Dionysia Kefala, Georgios Kladis, Alexandros Nianias, Ruud Ruiter, Renée Poels, Irene Sarkar, Yash R. Patankar, Elena Merino, Rogier M. Reijmers, Kristine A. Frerichs, Huipin Yuan, Joost de Bruijn, Dina Stroopinsky, David Avigan, Niels W. C. J. van de Donk, Sonja Zweegman, Tuna Mutis, Michel Sadelain, Richard W. J. Groen, Maria Themeli

Publikováno v: Sci Transl Med
Katsarou, A, Sjöstrand, M, Naik, J, Mansilla-Soto, J, Kefala, D, Kladis, G, Nianias, A, Ruiter, R, Poels, R, Sarkar, I, Patankar, Y R, Merino, E, Reijmers, R M, Frerichs, K A, Yuan, H, de Bruijn, J, Stroopinsky, D, Avigan, D, van de Donk, N W C J, Zweegman, S, Mutis, T, Sadelain, M, Groen, R W J & Themeli, M 2021, ' Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence ', Science Translational Medicine, vol. 13, no. 623, pp. eabh1962 . https://doi.org/10.1126/scitranslmed.abh1962
Science Translational Medicine, 13(623). American Association for the Advancement of Science

Despite the high remission rates achieved using T cells bearing a chimeric antigen receptor (CAR) against hematogical malignancies, there is still a considerable proportion of patients who eventually experience tumor relapse. Clinical studies have es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765463c7f1b19d6ab9e114dacaf8699c
https://europepmc.org/articles/PMC9869449/

CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia

Autor: Regina de Jong-Korlaar, Anton C.M. Martens, Joost D. de Bruijn, Ruud W.J. Ruiter, Jyoti Naik, Richard W.J. Groen, Pino J. Poddighe, Huipin Yuan, Niels W.C.J. van de Donk, Gert J. Ossenkoppele, Maria Themeli, Sonja Zweegman, Linda Smit, Tuna Mutis

Publikováno v: Haematologica, 104(3), e100-e103. Ferrata Storti Foundation
Naik, J, Themeli, M, de Jong-Korlaar, R, Ruiter, R W J, Poddighe, P J, Yuan, H, de Bruijn, J D, Ossenkoppele, G J, Zweegman, S, Smit, L, Mutis, T, Martens, A C M, van de Donk, N W C J & Groen, R W J 2019, ' CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia ', Haematologica, vol. 104, no. 3, pp. e100-e103 . https://doi.org/10.3324/haematol.2018.192757

Acute leukemia is a clonal expansion of malignant hematopoietic cells leading to impaired production of normal blood cells in the bone marrow (BM). Acute leukemia can be classified, according to the lineage involved, into acute myeloid leukemia (AML)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe9a9250bcc439c5f5daecb96e6859d
https://research.vumc.nl/en/publications/3c8b5f25-1305-4d6f-a88e-856d787ba37c

Hepatic Cyp17a1 regulates the adaptive starvation response aia a nuclear receptor network

Autor: Alexandra Milona, Saski van Mil, Helen A.B. Paterson, Ellen C.L. Willemsen, Harmjan R. Vos, Irene Miguel-Aliaga, Santiago Vernia, Bryn M. Owen, Jyoti Naik, Boudewijn M.T. Burgering, Catherine Williamson, Piter J. Bosma, Natalia Artigas

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e54475b6cb1e7b3bb1c7008b8fd85c3b
https://doi.org/10.1530/endoabs.59.p175