Výsledky vyhledávání - "Jyoti, Mehrotra"

Evaluation of GSTP1 and APC methylation as indicators for repeat biopsy in a high-risk cohort of men with negative initial prostate biopsies

Autor: Eric A. Klein, David G. McLeod, Michelle Brotzman, Leslie A. Mangold, Joseph Bigley, Theresa McAskill, J. Stephen Jones, Bruce J. Trock, Jonathan I. Epstein, Alan W. Partin, Bhargavi Raghavan, Jyoti Mehrotra, Songbai Wang

Publikováno v: BJU International. 110:56-62

OBJECTIVE To evaluate the performance of DNA methylation biomarkers in the setting of repeat biopsy in men with an initially negative prostate biopsy but a high index of suspicion for missed prostate cancer. PATIENTS AND METHODS We prospectively eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d6e310476ffc7bc596f819249b8ed27
https://doi.org/10.1111/j.1464-410x.2011.10718.x

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Development of a Multiplexed Urine Assay for Prostate Cancer Diagnosis

Autor: Tatiana Vener, Carlo Derecho, Dondapati Chowdary, Haiying Wang, Georg Schäfer, Shobha Varde, Sebastian Mannweiler, Peter Amersdorfer, Marco Auprich, Howard Robin, Alexandre E. Pelzer, Yashoda Rajpurohit, Jonathan Baden, Joanne Skelton, Bradley C. Leibovich, Abhijit Mazumder, Jyoti Mehrotra, Walt Stallings

Publikováno v: Clinical Chemistry. 54:874-882

Background: Several studies have demonstrated the value of DNA methylation in urine-based assays for prostate cancer diagnosis. However, a multicenter validation with a clinical prototype has not been published. Methods: We developed a multiplexed, q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968d03cae5148d41e2a1c7ecef8bfd3a
https://doi.org/10.1373/clinchem.2007.094912

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Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer

Autor: Pang Kuo Lo, Mary Jo Fackler, Jyoti Mehrotra, Saraswati Sukumar, Pedram Argani, Elizabeth Garrett-Mayer, Anisha D’costa

Publikováno v: Cancer Biology & Therapy. 5:281-286

Expression of Secreted frizzled related protein 1 (SFRP1), a recently identified tumor suppressor gene encoding a WNT signaling antagonist, has been found to be frequently down-regulated in breast cancer and is associated with disease progression and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173d7b9f1b3db71b253fbfb56f873b5a
https://doi.org/10.4161/cbt.5.3.2384

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Quantitative Multiplex Methylation-Specific PCR Assay for the Detection of Promoter Hypermethylation in Multiple Genes in Breast Cancer

Autor: Mary Jo Fackler, Megan McVeigh, Pedram Argani, Elizabeth Garrett, Saraswati Sukumar, Amanda Lapides, Jyoti Mehrotra, Julie R. Lange, Marissa A. Blum

Publikováno v: Cancer Research. 64:4442-4452

If detected early, breast cancer is eminently curable. To detect breast cancer in samples with little cellularity, a high level of sensitivity is needed. Tumor-specific promoter hypermethylation has provided such a valuable tool for detection of canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0913ff3376ea4daf74eb14fda0a6dd
https://doi.org/10.1158/0008-5472.can-03-3341

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Estrogen Receptor/Progesterone Receptor-Negative Breast Cancers of Young African-American Women Have a Higher Frequency of Methylation of Multiple Genes than Those of Caucasian Women1

Autor: Megan McVeigh, Giovanni Parmigiani, Kornelia Polyak, Yasmine Kanaan, Carolyn Broome, Pedram Argani, Tammy Naab, Mary Jo Fackler, Jyoti Mehrotra, Jaana Lahti-Domenici, Saraswati Sukumar, Elizabeth Garrett, M. Michelle Ganpat

Publikováno v: Clinical Cancer Research. 10:2052-2057

Purpose: To provide a molecular rationale for negative prognostic factors more prevalent in African-American (AA) than Caucasian (Cau) women, we investigated the frequency of promoter hypermethylation in invasive ductal breast cancers in the two race

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::695e3efb078995228cf0b65f4d384357
https://doi.org/10.1158/1078-0432.ccr-03-0514

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DNA methylation ofRASSF1A, HIN-1, RAR-?, Cyclin D2 andTwist inin situ and invasive lobular breast carcinoma

Autor: Saraswati Sukumar, Ella Evron, Megan McVeigh, Pedram Argani, Mary Jo Fackler, Jyoti Mehrotra, Elizabeth Garrett, Kornelia Polyak

Publikováno v: International Journal of Cancer. 107:970-975

Little is known about epigenetic silencing of genes by promoter hypermethylation in lobular breast cancers. The promoter methylation status of 5 cancer-related genes (RASSF1A, HIN-1, RAR-β, Cyclin D2 and Twist) was evaluated in 2 types of lobular ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08811e4558b5c98469cc92e21c2ea33f
https://doi.org/10.1002/ijc.11508

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Reduced immunopathology and mortality despite tissue persistence in aMycobacterium tuberculosismutant lacking alternative σ factor, SigH

Autor: Liane Carpenter, William R. Bishai, Jyoti Mehrotra, Sandeep Tyagi, Tetsuyuki Yoshimatsu, Deepak Kaushal, Benjamin G. Schroeder, Robert D. Fleischmann, Chiew Ko, Cherise P. Scott, Yukari C. Manabe

Publikováno v: Proceedings of the National Academy of Sciences. 99:8330-8335

The pathogenesis of tuberculosis involves multiple phases and is believed to involve both a carefully deployed series of adaptive bacterial virulence factors and inappropriate host immune responses that lead to tissue damage. A definedMycobacterium t

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https://doi.org/10.1073/pnas.102055799

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Regulation of virulence genes in Mycobacterium tuberculosis

Autor: William R. Bishai, Jyoti Mehrotra

Publikováno v: International Journal of Medical Microbiology. 291:171-182

Mycobacterium tuberculosis has demonstrated remarkable ability to survive in diverse conditions encountered during the infection process. These involve surviving the bactericidal stresses within the macrophage, the anaerobic and nutritionally altered

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https://doi.org/10.1078/1438-4221-00113

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DNA Intercalation and Photoinduced Cleavage by 4-Nitro(N-Hexylamine)1,8-Naphthalimide

Autor: Krishna Misra, Rakesh Mishra, Jyoti Mehrotra

Publikováno v: Nucleosides and Nucleotides. 13:963-978

A novel intercalator, 4-nitro(N-hexylamine)1,8-naphthalimide, was synthesised and its DNA binding and photoinduced DNA cleavage properties were studied. The DNA unwinding results show that it binds through intercalation. Absorption and fluorescence s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54444399839da0425f14d02aeab9bd62
https://doi.org/10.1080/15257779408011870

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Sequence Specific Chemical Recognition Of DNA

Autor: Rakesh Mishra, Krishna Misra, Jyoti Mehrotra

Publikováno v: Nucleosides and Nucleotides. 10:609-613

DNA intercalators which can covalently modify DNA, under specified conditions, have been synthesised. These compo- unds have been linked to heptathymildilic acid which has potential to recognise DNA sequence specifically, by triple helix formation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15d39fc19cbaac7931213d7675280b6a
https://doi.org/10.1080/07328319108046547

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