Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jyoti, Disa"'
Autor:
Tayeba Khan, Hans Weber, Jillian DiMuzio, Andrea Matter, Belma Dogdas, Tosha Shah, Anil Thankappan, Jyoti Disa, Vasant Jadhav, Laura Lubbers, Laura Sepp-Lorenzino, Walter R Strapps, Marija Tadin-Strapps
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Short interfering RNAs (siRNAs) are a valuable tool for gene silencing with applications in both target validation and therapeutics. Many advances have recently been made to improve potency and specificity, and reduce toxicity and immunostimulation.
Externí odkaz:
https://doaj.org/article/9a7acd7483d440b2819be46e26aa76dd
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
Autor:
Zhu Chen, Bin Luo, Tian-Quan Cai, Anil Thankappan, Yiming Xu, Weizhen Wu, Jillian DiMuzio, Traci Lifsted, Marty DiPietro, Jyoti Disa, Bruce Ng, Karen Leander, Seth Clark, Lizbeth Hoos, Yuchen Zhou, Nina Jochnowitz, Christine Jachec, Peter Szczerba, Marian E Gindy, Walter Strapps, Laura Sepp-Lorenzino, Dietmar A Seiffert, Laura Lubbers, Marija Tadin-Strapps
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA
Externí odkaz:
https://doaj.org/article/da51b10ff9c64e0ebedcb655dbab5e3c
Autor:
Andus Hon-Kit Wong, Robert E. Drolet, Galya Vassileva, Cheryl A. Gretzula, Paige Cramer, Jyoti Disa, Marija Tadin-Strapps, David J. Stone, Bhavya Voleti, Sarah Jinn, Dawn Toolan
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2389-2394
Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies, depositions of insoluble α-synuclein, and other proteins that likely contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac18fc109c991ebfd1af11dfbf9d4505
https://doi.org/10.1073/pnas.1616332114
https://doi.org/10.1073/pnas.1616332114
Autor:
Anil Thankappan, Laura Sepp-Lorenzino, Andrea Matter, Vasant Jadhav, Tosha Shah, Jyoti Disa, Belma Dogdas, Walter Strapps, Marija Tadin-Strapps, Tayeba Khan, Hans Weber, Jillian DiMuzio, Laura S. Lubbers
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Short interfering RNAs (siRNAs) are a valuable tool for gene silencing with applications in both target validation and therapeutics. Many advances have recently been made to improve potency and specificity, and reduce toxicity and immunostimulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35236a138dff84ad422078733f39733
Autor:
Mcmillan Lynette Jane, David J. Behm, Jian Jin, Kalindi Vaidya, Zining Wu, Michael J. Neeb, Dongchuan Shi, Karl F. Erhard, Feng Wang, Brian F. Guida, Sarah K. Lawrence, Christopher P. Evans, Stephen A. Douglas, Yonghui Wang, Ralph A. Rivero, Jyoti Disa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2860-2864
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93b7e819e4a3037dabc6f377d61bfb1
https://doi.org/10.1016/j.bmcl.2008.03.078
https://doi.org/10.1016/j.bmcl.2008.03.078
Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells
Autor:
Douglas G. Johns, Nambi Aiyar, Stephen A. Douglas, Haisong Ju, Sandhya S. Nerurkar, Jyoti Disa, Colin H. Macphee, Zhaohui Ao, Robert N. Willette
Publikováno v:
Molecular and Cellular Biochemistry. 295:113-120
Lysophosphatidylcholine (LPC) is the major bioactive lipid component of oxidized LDL, thought to be responsible for many of the inflammatory effects of oxidized LDL described in both inflammatory and endothelial cells. Inflammation-induced transforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddbbbc3a7ff7ac8496adac4e852eb42
https://doi.org/10.1007/s11010-006-9280-x
https://doi.org/10.1007/s11010-006-9280-x
Autor:
Richard M. Keenan, Henry M. Sarau, Nambi Aiyar, David J. Behm, Schmidt Stanley J, Lisa T. Christmann, Steven D. Knight, William E. Wixted, Lance Ridgers, Peter T. Buckley, Timothy Francis Gallagher, James J. Foley, Graham J. Riley, John G Gleason, Jyoti Disa, Diane Naselsky, Dashyant Dhanak, Stephen A. Douglas, Jian Jin, Widdowson Katherine L, Dulcie B. Schmidt, David P. Brooks, Eliot H. Ohlstein
Publikováno v:
British Journal of Pharmacology. 145:620-635
1. SB-706375 potently inhibited [(125)I]hU-II binding to both mammalian recombinant and 'native' UT receptors (K(i) 4.7+/-1.5 to 20.7+/-3.6 nM at rodent, feline and primate recombinant UT receptors and K(i) 5.4+/-0.4 nM at the endogenous UT receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512cc94fd61162d159591dcd2189f2bc
https://doi.org/10.1038/sj.bjp.0706229
https://doi.org/10.1038/sj.bjp.0706229
Autor:
Douglas G. Johns, Peter T. Buckley, Henry M. Sarau, Nabil Elshourbagy, James J. Foley, David J. Behm, Nambi V. Aiyar, Jyoti Disa, Zhaohui Ao, Stephen A. Douglas, Harjeet K. van-der-Keyl
Publikováno v:
Biochemical Pharmacology. 69:1069-1079
Urotensin-II (U-II), acting through its G-protein-coupled receptor, UT, is a possible contributor to hypertension. Variable functional responses to U-II, both within and between species studied to date, complicate the characterization of UT antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be61db4caa83c7ddb27d80795c79c90
https://doi.org/10.1016/j.bcp.2004.12.016
https://doi.org/10.1016/j.bcp.2004.12.016
Autor:
James J. Foley, Donald C. Carptenter, Diane P. Naselsky, Henry M. Sarau, Nambi V. Aiyar, Appelbaum Edward Robert, Jyoti Disa, Sujoy Ghosh, Klaudia Steplewski, Eric N. Johnson, Richard F. Cox, Mark A. Pullen, Samuel R. Scheff, Meirav Zaks-Zilberman
Publikováno v:
The Journal of Immunology. 173:7230-7238
Neuromedin U (NmU), originally isolated from porcine spinal cord and later from other species, is a novel peptide that potently contracts smooth muscle. NmU interacts with two G protein-coupled receptors designated as NmU-1R and NmU-2R. This study de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a1c7fee8f1d24d7433370df26e95ed
https://doi.org/10.4049/jimmunol.173.12.7230
https://doi.org/10.4049/jimmunol.173.12.7230
Autor:
Nambi Aiyar, Diane Naselsky, Zhaohui Ao, Christopher L Herold, Frank Lynch, Stephen A. Douglas, Jyoti Disa
Publikováno v:
British Journal of Pharmacology. 142:921-932
1 In an effort to identify endogenous, native mammalian urotensin-II (U-II) receptors (UT), a diverse range of human, primate and rodent cell lines (49 in total) were screened for the presence of detectable [125I]hU-II binding sites. 2 UT mRNA (North
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e519430918a9e1dc2ccb774cfdc5a8ed
https://doi.org/10.1038/sj.bjp.0705743
https://doi.org/10.1038/sj.bjp.0705743