Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jyothsna Visweswaraiah"'
Autor:
Silvia Crescioli, Hélène Kaplon, Alicia Chenoweth, Lin Wang, Jyothsna Visweswaraiah, Janice M. Reichert
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTThe ‘Antibodies to Watch’ article series provides an annual summary of commercially sponsored monoclonal antibody therapeutics currently in late-stage clinical development, regulatory review, and those recently granted a first approval in
Externí odkaz:
https://doaj.org/article/78f76dc3c6894aaab7db6a160a50fdc8
Autor:
Hélène Kaplon, Silvia Crescioli, Alicia Chenoweth, Jyothsna Visweswaraiah, Janice M. Reichert
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTIn this 14th installment of the annual Antibodies to Watch article series, we discuss key events in commercial monoclonal antibody therapeutics development that occurred in 2022 and forecast events that might occur in 2023. As of mid-November
Externí odkaz:
https://doaj.org/article/2ffd642807bf49b48c679d5a0397d669
Autor:
Swati Gaikwad, Fardin Ghobakhlou, David J Young, Jyothsna Visweswaraiah, Hongen Zhang, Alan G Hinnebusch
Publikováno v:
eLife, Vol 10 (2021)
In eukaryotes, 43S preinitiation complex (PIC) formation is a rate-determining step of translation. Ribosome recycling following translation termination produces free 40S subunits for re-assembly of 43S PICs. Yeast mutants lacking orthologs of mammal
Externí odkaz:
https://doaj.org/article/e39deb7ff5ef4afcb85e31f01fb99d02
Publikováno v:
eLife, Vol 6 (2017)
The eukaryotic pre-initiation complex (PIC) bearing the eIF2·GTP·Met-tRNAiMet ternary complex (TC) scans the mRNA for an AUG codon in favorable context. AUG recognition evokes rearrangement of the PIC from an open, scanning to a closed, arrested co
Externí odkaz:
https://doaj.org/article/83981e19367942159ed87d951631531e
Publikováno v:
eLife, Vol 4 (2015)
The eukaryotic 43S pre-initiation complex bearing tRNAiMet scans the mRNA leader for an AUG start codon in favorable context. Structural analyses revealed that the β-hairpin of 40S protein Rps5/uS7 protrudes into the 40S mRNA exit-channel, contactin
Externí odkaz:
https://doaj.org/article/253b6eaef25b4dbf9610a17b99b14a99
Autor:
Hélène Kaplon, Silvia Crescioli, Alicia Chenoweth, Jyothsna Visweswaraiah, Janice M. Reichert
Publikováno v:
mAbs. 15
In this 14th installment of the annual Antibodies to Watch article series, we discuss key events in commercial monoclonal antibody therapeutics development that occurred in 2022 and forecast events that might occur in 2023. As of mid-November, 12 ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c74d053d8e49ae777e751a24d6da6ef
https://doi.org/10.1080/19420862.2022.2153410
https://doi.org/10.1080/19420862.2022.2153410
Autor:
Bridget M Larkin, Jyothsna Visweswaraiah, Bilian Li, Komal Pradhan, Michael Rowe, Gaurav Rajani, Celesztina Nagy-Domonkos, Nathan Higginson-Scott, Joanne L Viney, Kevin L Otipoby, Hussam H Shaheen, Ivan Mascanfroni
Publikováno v:
The Journal of Immunology. 206:28.20-28.20
Regulatory T cells (Treg) play a critical role in maintaining graft tolerance following organ transplantation, and increased numbers of Tregs in solid-tissue grafts such as the kidney are associated with improved graft survival and function. Therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3de40a01ab7f5d2eedf66a12743a1b
https://doi.org/10.4049/jimmunol.206.supp.28.20
https://doi.org/10.4049/jimmunol.206.supp.28.20
Autor:
Jyothsna Visweswaraiah, Erik R Sampson, Timothy Kiprono, Parika Petaipimol, Adrianne Monsef, Katalin Kis-Toth, Kevin L Otipoby, John Sundy, Nathan Higginson-Scott, Joanne L Viney
Publikováno v:
The Journal of Immunology. 206:66.14-66.14
Regulatory T cells (Treg) are vital for immune homeostasis and are dysfunctional in autoimmunity. Interleukin 2 (IL-2) drives the proliferation and function of Tregs via its heterotrimeric receptor (CD25/CD122/CD132). Low dose IL-2 is being evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65768ddf9e253248a7bec80943d34b0c
https://doi.org/10.4049/jimmunol.206.supp.66.14
https://doi.org/10.4049/jimmunol.206.supp.66.14