Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jyothishmathi Swaminathan"'
Autor:
Ashutosh Singh, Donghang Cheng, Jyothishmathi Swaminathan, Yanwen Yang, Yan Zheng, Nancy Gordon, Vidya Gopalakrishnan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The RE1 silencing transcription factor (REST) is a driver of sonic hedgehog (SHH) medulloblastoma genesis. Our previous studies showed that REST enhances cell proliferation, metastasis and vascular growth and blocks neuronal differentiation
Externí odkaz:
https://doaj.org/article/1ed74e9c2f9940068158fa62483d53f1
Autor:
Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W. Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J. Lazar, J. Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C. Daw, Nicholas E. Navin, Richard Gorlick, Joseph A. Ludwig
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell level. Classification of bulk tumors by their individual cellular constit
Externí odkaz:
https://doaj.org/article/482dd5ae5a4547e1b7a5b46f06fd1adc
Autor:
Robert Siddaway, Scott Milos, Arun Kumaran Anguraj Vadivel, Tara H. W. Dobson, Jyothishmathi Swaminathan, Scott Ryall, Sanja Pajovic, Palak G. Patel, Javad Nazarian, Oren Becher, Michael Brudno, Arun Ramani, Vidya Gopalakrishnan, Cynthia Hawkins
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Targeting genetic drivers of high grade diffuse glioma (HGG) has not improved patient survival, suggesting the involvement of other mechanisms. Here, across cancer types, the authors identify increased alternative splicing burden in cancer drivers co
Externí odkaz:
https://doaj.org/article/16682e61ebb34dd9b0ee5d0b70707f1e
Autor:
Shavali Shaik, Shinji Maegawa, Amanda R Haltom, Feng Wang, Xue Xiao, Tara Dobson, Ajay Sharma, Yanwen Yang, Jyothishmathi Swaminathan, Vikas Kundra, Xiao Nan Li, Keri Schadler, Arif Harmanci, Lin Xu, Vidya Gopalakrishnan
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1486-1506 (2021)
Expression of the RE1‐silencing transcription factor (REST), a master regulator of neurogenesis, is elevated in medulloblastoma (MB) tumors. A cell‐intrinsic function for REST in MB tumorigenesis is known. However, a role for REST in the regulati
Externí odkaz:
https://doaj.org/article/2fd985365fb74e1ca2c9a58c50c1a78b
Autor:
Jyothishmathi Swaminathan, Shinji Maegawa, Shavali Shaik, Ajay Sharma, Javiera Bravo-Alegria, Lei Guo, Lin Xu, Arif Harmanci, Vidya Gopalakrishnan
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The RE1 Silencing Transcription Factor (REST) is a major regulator of neurogenesis and brain development. Medulloblastoma (MB) is a pediatric brain cancer characterized by a blockade of neuronal specification. REST gene expression is aberrantly eleva
Externí odkaz:
https://doaj.org/article/adbcf35e4afc4f71ab1fa836a5a1653c
Autor:
Vidya Gopalakrishnan, Gianluca Sbardella, Pete H. Taylor, Sabrina Castellano, Ciro Milite, Rong-Hua Tao, Shavali Shaik, Chandra M. Das, Jyothishmathi Swaminathan, Rashieda J. Hatcher, Tara H.W. Dobson
Primers for QRT-PCR Assay, Antibodies for ChIP, Primers for qChIP Assay, Antibodies for Western Blotting and Antibodies for IHC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d70c00d4a1aae24675d61370216f2b
https://doi.org/10.1158/1541-7786.22515493.v1
https://doi.org/10.1158/1541-7786.22515493.v1
Autor:
Vidya Gopalakrishnan, Gianluca Sbardella, Pete H. Taylor, Sabrina Castellano, Ciro Milite, Rong-Hua Tao, Shavali Shaik, Chandra M. Das, Jyothishmathi Swaminathan, Rashieda J. Hatcher, Tara H.W. Dobson
The deubiquitylase (DUB) USP37 is a component of the ubiquitin system and controls cell proliferation by regulating the stability of the cyclin-dependent kinase inhibitor 1B, (CDKN1B/p27Kip1). The expression of USP37 is downregulated in human medullo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::299d376b39ac7da31036534d14be7f73
https://doi.org/10.1158/1541-7786.c.6541108
https://doi.org/10.1158/1541-7786.c.6541108
Autor:
Amanda R. Haltom, Ajay Sharma, Vidya Gopalakrishnan, Shinji Maegawa, Lin Xu, Jyothishmathi Swaminathan, Tara Dobson, Xue Xiao, Vikas Kundra, Xiao-Nan Li, Yanwen Yang, Shavali Shaik, Arif Harmanci, Keri Schadler, Feng Wang
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1486-1506 (2021)
Molecular Oncology
Molecular Oncology
Expression of the RE1‐silencing transcription factor (REST), a master regulator of neurogenesis, is elevated in medulloblastoma (MB) tumors. A cell‐intrinsic function for REST in MB tumorigenesis is known. However, a role for REST in the regulati
Autor:
Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W. Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J. Lazar, John A. Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C. Daw, Richard Gorlick, Joseph A. Ludwig
BackgroundSingle-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell level. Classification of bulk tumors by their individual cellular constituents has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a65eca7e4fdd36aeec0be5f7b84ccc3
https://doi.org/10.1101/2022.01.21.476982
https://doi.org/10.1101/2022.01.21.476982
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2423
Studies of DNA-protein interactions have revealed regulatory mechanisms of DNA replication, repair, remodeling, and transcription. Perturbation of any or all of these processes result in differential gene expression that can lead to tumor development