Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jyothi Mahadevaswamy"'
Autor:
Vijender Panduga, Manoranjan Panda, Radha Shandil, Shridhar Narayanan, Naveen Kumar, M Sreenivasaiah, Monalisa Chatterji, Pravin S. Shirude, Claire Sadler, Vasan K. Sambandamurthy, Tommasi Ruben A, Supreeth Guptha, Jyothi Mahadevaswamy, Meenakshi Mallya, Pravin Iyer, Sreevalli Sharma, Vasanthi Ramachandran, Christopher B. Cooper, Anisha Ambady, Ashwini Narayan, Manjunatha M R, Khisi Mdluli, Scott Butler
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report a novel benzimidazole (BI) based DprE1 inhibitor that resulted from scaffold morphing of a 1,4-azaindole series. The clinical progression of the 1,4-azaindole series from our previous work validates the potential of explor
Autor:
Vaishali Humnabadkar, Claire Sadler, Tanjore S. Balganesh, Prakash Vachaspati, Disha Awasthy, Manoranjan Panda, Mick D. Fellows, Parvinder Kaur, Stewart T. Cole, Florence Pojer, Vasan K. Sambandamurthy, João Neres, Sreevalli Sharma, V. Balasubramanian, Kannan Murugan, Meenakshi Mallya, Suresh Rudrapatna, Balachandra Bandodkar, Sudhir Landge, Bheemarao G. Ugarkar, Jyothi Mahadevaswamy, Kavitha Nagalapur, Amrita B. Mullick, Vasanthi Ramachandran, Anirban Ghosh, Venkita Subbulakshmi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7694-7710
We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign. Benzothiazoles exert their bactericidal activity against Mycobacterium tuberculosis (Mtb) through potent inhibition o
Autor:
Parvinder Kaur, Anisha Ambady, Sreevalli Sharma, Vinayak Hosagrahara, Ashwini Narayan, Vasanthi Ramachandran, Suresh Rudrapatna, Supreeth Guptha, Pravin S. Shirude, Vasan K. Sambandamurthy, Jyothi Mahadevaswamy, Ramachandran Sreekanth A, Kavitha Nagalapur, Anandkumar Raichurkar, Naina Hegde, Manoranjan Panda, Vaishali Humnabadkar
Publikováno v:
Journal of Medicinal Chemistry. 57:4761-4771
A novel pyrazolopyridone class of inhibitors was identified from whole cell screening against Mycobacterium tuberculosis (Mtb). The series exhibits excellent bactericidality in vitro, resulting in a 4 log reduction in colony forming units following c
Autor:
Monalisa Chatterji, João Neres, Sreevalli Sharma, Prashanti Madhavapeddi, Vijender Panduga, James D. Whiteaker, Suresh Rudrapatna, Chandan Narayan, Krishna Koushik, Laurent R. Chiarelli, Gajanan Shanbhag, Vaishali Humnabadkar, Gopinath Gorai, Claudia Binda, Sandeep R. Ghorpade, Radha Shandil, Neeraj Dhar, Maria Rosalia Pasca, Stefan Kavanagh, Vasan K. Sambandamurthy, M. R. Manjunatha, K.R. Prabhakar, Vijayashree Achar, John D. McKinney, Neela Dinesh, Naina Hegde, Praveena Manjrekar, François Signorino-Gelo, Parvinder Kaur, Shridhar Narayanan, Jitendar Reddy, Subramanyam J. Tantry, Ashwini Narayan, Sandesh Jatheendranath, Lalit kumar Jena, Tommasi Ruben A, Jyothi Mahadevaswamy, Disha Awasthy, Ramanatha Saralaya, Manoranjan Panda, Bob McLaughlin, Anisha Ambady, Vinayak Hosagrahara, Pravin Iyer, Chandramohan Bathula, Maruti Naik, Giovanna Riccardi, Supreeth Guptha, Sudha Ravishankar, Vasanthi Ramachandran
Publikováno v:
Journal of medicinal chemistry. 57(12)
4-Aminoquinolone piperidine amides (AQs) were identified as a novel scaffold starting from a whole cell screen, with potent cidality on Mycobacterium tuberculosis (Mtb). Evaluation of the minimum inhibitory concentrations, followed by whole genome se
Autor:
Jyothi Mahadevaswamy, Naina Hegde, Shridhar Narayanan, Vijender Panduga, Ashwini Narayan, Ramesh R. Kale, Pravin Iyer, Claire Sadler, Parvinder Kaur, Abhishek Srivastava, Chandramohan Bathula, Vinayak Hosagrahara, Sowmya Bharath, K. G. Vishwas, Chandan Narayan, Suresh Solapure, Prashanti Madhavapeddi, James D. Whiteaker, Maruti Naik, Vaishali Humnabadkar, Nilanjana Roy Choudhury, Supreeth Guptha, Monalisa Chatterji, Humphrey Gardner, Anisha Ambady, K.R. Prabhakar, Radha Shandil, Vasan K. Sambandamurthy, Disha Awasthy, Vasanthi Ramachandran, Vijaykamal Ahuja, Jitendar Reddy, Robert E. McLaughlin, Shahul Hameed, Sreevalli Sharma, Pravin S. Shirude, Naveen Kumar, Manjunatha Ramaiah, Vikas Shinde
Publikováno v:
Journal of medicinal chemistry. 56(23)
We report 1,4-azaindoles as a new inhibitor class that kills Mycobacterium tuberculosis in vitro and demonstrates efficacy in mouse tuberculosis models. The series emerged from scaffold morphing efforts and was demonstrated to noncovalently inhibit d