MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology.

Autor: Jyothi K Mallajosyula, Deepinder Kaur, Shankar J Chinta, Subramanian Rajagopalan, Anand Rane, David G Nicholls, Donato A Di Monte, Heather Macarthur, Julie K Andersen

Publikováno v: PLoS ONE, Vol 3, Iss 2, p e1616 (2008)

Age-related increases in monoamine oxidase B (MAO-B) may contribute to neurodegeneration associated with Parkinson's disease (PD). The MAO-B inhibitor deprenyl, a long-standing antiparkinsonian therapy, is currently used clinically in concert with th

Externí odkaz: https://doaj.org/article/b8482a61d62f4122afaf4ad8c7643b7a

Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: Implications for early intervention on disease progression

Autor: Almas Siddiqui, Jyothi K. Mallajosyula, Anand Rane, Julie K. Andersen

Publikováno v: Neurobiology of Disease, Vol 40, Iss 2, Pp 444-448 (2010)

We previously demonstrated that elevation of astrocytic monoamine oxidase B (MAO-B) levels in a doxycycline (dox)-inducible transgenic mouse model following 14 days of dox induction results in several neuropathologic features similar to those observe

Externí odkaz: https://doaj.org/article/1dc1a0e789444e4e87db97fe7acbd9a5

Corrigendum to 'Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: Implications for early intervention on disease progression' [Neurobiol Dis. 40/2 (2010) 444–448]

Autor: Almas Siddiqui, Jyothi K. Mallajosyula, Anand Rane, Julie K. Andersen

Publikováno v: Neurobiology of Disease, Vol 43, Iss 2, Pp 526- (2011)

Externí odkaz: https://doaj.org/article/aa586546f977440b8be077f1229db4a2

In planta Production of Flock House Virus Transencapsidated RNA and Its Potential Use as a Vaccine

Autor: Payal D. Maharaj, Christopher M. Kearney, Alison A. McCormick, Yiyang Zhou, Jyothi K. Mallajosyula

Publikováno v: Molecular Biotechnology. 57:325-336

We have developed a transencapsidated vaccine delivery system based on the insect virus, Flock House virus (FHV). FHV is attractive due to its small genome size, simple organization, and nonpathogenic characteristics. With the insertion of a Tobacco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4984822a934e06efa9965c2a7cb07c
https://doi.org/10.1007/s12033-014-9826-1

Nanoparticle Encapsidation of Flock House Virus by Auto Assembly of Tobacco Mosaic Virus Coat Protein

Autor: Yiyang Zhou, Christopher M. Kearney, Phillip Thi, Alison A. McCormick, Payal D. Maharaj, Gloria Lee, Jyothi K. Mallajosyula

Publikováno v: International Journal of Molecular Sciences
Volume 15
Issue 10
Pages 18540-18556
International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 18540-18556 (2014)

Tobacco Mosaic virus (TMV) coat protein is well known for its ability to self-assemble into supramolecular nanoparticles, either as protein discs or as rods originating from the ~300 bp genomic RNA origin-of-assembly (OA). We have utilized TMV self-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01c75f91194fe3dd242cc850dfbd21b
http://europepmc.org/articles/PMC4227231