Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jyothi Dhuguru"'
Publikováno v:
Nutrients, Vol 15, Iss 13, p 3064 (2023)
Dietary vitamin B3 components, such as nicotinamide and nicotinic acid, are precursors to the ubiquitous redox cofactor nicotinamide adenine dinucleotide (NAD+). NAD+ levels are thought to decline with age and disease. While the drivers of this decli
Externí odkaz:
https://doaj.org/article/a26dc73ed81e469db7acfe5754be1311
Autor:
Jyothi Dhuguru, Marie E. Migaud
Publikováno v:
Molbank, Vol 2022, Iss 4, p M1463 (2022)
Isotope labelling of otherwise endogenous metabolites has emerged as a powerful approach to study metabolism-related biological processes, when used in conjunction with nuclear magnetic resonance or chromatography-supported mass spectrometry. Given t
Externí odkaz:
https://doaj.org/article/9f89e4f51b2d48acb88d8763b4fa6c94
Autor:
Jyothi Dhuguru, Ola A. Ghoneim
Publikováno v:
Molecules, Vol 27, Iss 7, p 2294 (2022)
Cancer is the most devastating disease and second leading cause of death around the world. Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocrine therapy, immunotherapy, ra
Externí odkaz:
https://doaj.org/article/0bba851a35544599961ec3844c0bd59d
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 66 (2022)
Despite the scientific advancements, organophosphate (OP) poisoning continues to be a major threat to humans, accounting for nearly one million poisoning cases every year leading to at least 20,000 deaths worldwide. Oximes represent the most importan
Externí odkaz:
https://doaj.org/article/d336654885f04546ac7dd7a390fe328c
Autor:
Jyothi Dhuguru, Rachid Skouta
Publikováno v:
Molecules, Vol 25, Iss 7, p 1615 (2020)
Lung cancer is the leading cause of death in men and women worldwide, affecting millions of people. Between the two types of lung cancers, non-small cell lung cancer (NSCLC) is more common than small cell lung cancer (SCLC). Besides surgery and radio
Externí odkaz:
https://doaj.org/article/0db0350b18ec424d9827bb5aba191108
Publikováno v:
Inflammation. 39:2053-2061
Pro-inflammatory mediators including TNF-alpha, IL-6, and nitric oxide are important for the regulation of the immune response when an infection is present, but when overproduced, it can be responsible for the development of tissue and organ injury s
Publikováno v:
Journal of Chemical Education. 94:1388-1390
The addition of a nucleophilic functional group to an electron-deficient aromatic ring is a versatile reaction in the modern organic chemistry arsenal. The proper positioning of a leaving group on this ring effectively allows for a substitution react
Publikováno v:
Bioorganicmedicinal chemistry. 26(14)
Infection triggers the release of pro-inflammatory cytokines (TNF-alpha and IL-6). Over-production, however, cause tissue injury seen in severe asthma. The ability of enaminone E121 to reduce pro-inflammatory cytokines in our laboratory encouraged fu
Publikováno v:
Biochemical pharmacology. 146
Agonism of the G protein-coupled free-fatty acid receptor-4 (FFA4) has been shown to promote numerous anti-inflammatory effects in macrophages that arise due to interaction with β-arrestin partner proteins. Humans express functionally distinct short
Autor:
Doreen Szollosi, Mohammed Manzoor, Victoria Lucero, Jyothi Dhuguru, Ivan Edafiogho, Ola Ghoneim
Publikováno v:
The Journal of Immunology. 198:72.5-72.5
Previous experiments in our laboratory have screened several novel compounds for anti-inflammatory activity, including enaminone E121 and the related JODI series. These studies have concluded that these compounds decrease the release of pro-inflammat