Výsledky vyhledávání - "Jyothi, Manohar"

Akademický článek

The evolution of metastatic upper tract urothelial carcinoma through genomic-transcriptomic and single-cell protein markers analysis

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract The molecular characteristics of metastatic upper tract urothelial carcinoma (UTUC) are not well understood, and there is a lack of knowledge regarding the genomic and transcriptomic differences between primary and metastatic UTUC. To addres

Externí odkaz: https://doaj.org/article/1f8f0d770af047ad8d9323c78d5a4be4

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Akademický článek

Deciphering the origin and therapeutic targets of cancer of unknown primary: a case report that illustrates the power of integrative whole-exome and transcriptome sequencing analysis

Publikováno v: Frontiers in Oncology, Vol 13 (2024)

Cancer of unknown primary (CUP) represents a significant diagnostic and therapeutic challenge, being the third to fourth leading cause of cancer death, despite advances in diagnostic tools. This article presents a successful approach using a novel ge

Externí odkaz: https://doaj.org/article/13acdf4ab307414bb760f79ae7f83824

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Akademický článek

Case report: Metastatic urothelial cancer with an exceptional response to immunotherapy and comprehensive understanding of the tumor and the tumor microenvironment

Autor: Cora N. Sternberg, Nara Shin, Konstantin Chernyshov, Fabio Calabro, Linda Cerbone, Giuseppe Procopio, Natalia Miheecheva, Georgy Sagaradze, Alisa Zaichikova, Naira Samarina, Alexandra Boyko, Jessica H. Brown, Leysan Yunusova, Daniela Guevara, Jyothi Manohar, Michael Sigouros, Majd Al Assaad, Olivier Elemento, Juan Miguel Mosquera

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Although immune checkpoint inhibitors (ICIs) are increasingly used as second-line treatments for urothelial cancer (UC), only a small proportion of patients respond. Therefore, understanding the mechanisms of response to ICIs is critical to improve c

Externí odkaz: https://doaj.org/article/261fadd6de394c4e909ca5e76ae4df64

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Akademický článek

Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis

Autor: Vincenza Conteduca, Sheng-Yu Ku, Luisa Fernandez, Angel Dago-Rodriquez, Jerry Lee, Adam Jendrisak, Megan Slade, Cole Gilbertson, Jyothi Manohar, Michael Sigouros, Yipeng Wang, Ryan Dittamore, Rick Wenstrup, Juan Miguel Mosquera, Joseph D. Schonhoft, Himisha Beltran

Publikováno v: npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021)

Abstract Neuroendocrine prostate cancer is an aggressive variant of prostate cancer that may arise de novo or develop from pre-existing prostate adenocarcinoma as a mechanism of treatment resistance. The combined loss of tumor suppressors RB1, TP53,

Externí odkaz: https://doaj.org/article/192f8c4983314673aa85a47274caaba0

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Akademický článek

Functional comparison of exome capture-based methods for transcriptomic profiling of formalin-fixed paraffin-embedded tumors

Autor: Kyrillus S. Shohdy, Rohan Bareja, Michael Sigouros, David C. Wilkes, Princesca Dorsaint, Jyothi Manohar, Daniel Bockelman, Jenny Z. Xiang, Rob Kim, Kentaro Ohara, Kenneth Eng, Juan Miguel Mosquera, Olivier Elemento, Andrea Sboner, Alicia Alonso, Bishoy M. Faltas

Publikováno v: npj Genomic Medicine, Vol 6, Iss 1, Pp 1-10 (2021)

Abstract The availability of fresh frozen (FF) tissue is a barrier for implementing RNA sequencing (RNA-seq) in the clinic. The majority of clinical samples are stored as formalin-fixed, paraffin-embedded (FFPE) tissues. Exome capture platforms have

Externí odkaz: https://doaj.org/article/be290d96afc142fb9fcbd3a2e94604c7

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Akademický článek

Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology

Publikováno v: Translational Oncology, Vol 14, Iss 1, Pp 100944- (2021)

Background: Frequency of clinically relevant mutations in solid tumors by targeted and whole-exome sequencing is ∼30%. Transcriptome analysis complements detection of actionable gene fusions in advanced cancer patients. Goal of this study was to de

Externí odkaz: https://doaj.org/article/8726c544cc9845559727803f01fd27f6

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Akademický článek

INFLUENCE OF INDUSTRIAL WASTEWATER ON MORPHOLOGICAL AND CHLOROPHYLL CONTENT OF GROUNDNUT (ARACHIS HYPOGAEA L.).

Autor: SUDHAKAR, V., CH, JYOTHI MANOHAR, ABRAHAM, K., DAMODHARAM, T.

Publikováno v: Pollution Research; 2024, Vol. 43 Issue 1/2, p22-26, 5p

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