Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jyh-Ming Lin"'
Autor:
Krishne Gowda, Asif Raza, Venugopal Vangala, Nazir Ahmad Lone, Jyh Ming Lin, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Todd D. Schell, Gavin P. Robertson, Shantu Amin, Arun K. Sharma
Publikováno v:
Molecules, Vol 29, Iss 13, p 3114 (2024)
Aldehyde dehydrogenases (ALDHs) are a family of enzymes that aid in detoxification and are overexpressed in several different malignancies. There is a correlation between increased expression of ALDH and a poor prognosis, stemness, and resistance to
Externí odkaz:
https://doaj.org/article/df10bcda0e884b7ba107ccfdd1982f9a
Autor:
Gowda, Krishne, Raza, Asif, Vangala, Venugopal, Lone, Nazir Ahmad, Jyh Ming Lin, Singh, Jaikee Kumar, Srivastava, Sandeep Kumar, Schell, Todd D., Robertson, Gavin P., Amin, Shantu, Sharma, Arun K.
Publikováno v:
Molecules; Jul2024, Vol. 29 Issue 13, p1-25, 25p, 5 Charts, 13 Graphs
Autor:
Gijs Rikken, Kayla J. Smith, Noa J.M. van den Brink, Jos P.H. Smits, Krishne Gowda, Angela Alnemri, Gulsum E. Kuzu, Iain A. Murray, Jyh-Ming Lin, Jos G.A. Smits, Ivonne M. van Vlijmen-Willems, Shantu G. Amin, Gary H. Perdew, Ellen H. van den Bogaard
Publikováno v:
Biochemical Pharmacology, 208
Therapeutic aryl hydrocarbon receptor (AHR) modulating agents gained attention in dermatology as non-steroidal anti-inflammatory drugs that improve skin barrier properties. By exploiting AHR's known ligand promiscuity, we generated novel AHR modulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7172d2666ec03b70eb38539132641e5
https://hdl.handle.net/2066/290126
https://hdl.handle.net/2066/290126
Autor:
Troy D. Hubbard, Krishne Gowda, Jyh Ming Lin, Iain A. Murray, Qing Liu, Shantu Amin, Fangcong Dong, Philip B. Smith, Andrew D. Patterson, Gary H. Perdew, Charles A. Miller
Publikováno v:
J Proteome Res
The aryl hydrocarbon receptor (AHR) is a major regulator of immune function within the gastrointestinal tract. Resident microbiota are capable of influencing AHR-dependent signaling pathways via production of an array of bioactive molecules that act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4af10fec01cbab58a0efc92053099e1
https://doi.org/10.1021/acs.jproteome.8b00946
https://doi.org/10.1021/acs.jproteome.8b00946
Autor:
Jyh Ming Lin, Christopher G. Bazewicz, Raghavendra Gowda, Saketh S. Dinavahi, Robert Chitren, Madhu Babu Battu, Gavin P. Robertson, Krishne Gowda, Manoj K. Pandey, Shantu Amin
Publikováno v:
European journal of medicinal chemistry. 187
The aldehyde dehydrogenases (ALDHs) are a family of detoxifying enzymes that are overexpressed in various cancers. Increased expression of ALDH is associated with poor prognosis, stemness, and drug resistance. Because of the critical role of ALDH in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a325cdc57f8222f43266e31d2df90a7
https://pubmed.ncbi.nlm.nih.gov/31887569
https://pubmed.ncbi.nlm.nih.gov/31887569
Autor:
Hong Gang Wang, Christopher M. Dower, Kenichiro Doi, Qiang Liu, Shen Shu Sung, Krishne Gowda, David F. Claxton, Shantu Amin, Jyh Ming Lin, Thomas P. Loughran
Publikováno v:
Cancer Biology & Therapy. 15:1688-1699
Mcl-1, a pro-survival member of the Bcl-2 protein family, is an attractive target for cancer therapy. We have recently identified the natural product marinopyrrole A (maritoclax) as a novel small molecule Mcl-1 inhibitor. Here, we describe the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85b89f3a997d415897ba86b030a2615
https://doi.org/10.4161/15384047.2014.972799
https://doi.org/10.4161/15384047.2014.972799
Autor:
Arun Sharma, Gowdahalli Krishnegowda, Dhimant Desai, A. S. Prakasha Gowda, Jacek Krzeminski, Jyh Ming Lin, Shantu Amin, Thomas E. Spratt
Publikováno v:
Chemical Research in Toxicology. 24:960-967
O(2)-[4-(3-Pyridyl)-4-oxobut-1-yl]thymidine (O(2)-POB-dThd) is the most persistent adduct detected in the lung and liver of rats treated with tobacco specific nitrosamines: N'-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619a308db0cf0e599ae49455a1ebb4d5
https://doi.org/10.1021/tx200127j
https://doi.org/10.1021/tx200127j
Autor:
Brett C. DiNatale, Colin A. Flaveny, Gary H. Perdew, Jyh Ming Lin, Chris R. Chiaro, Gowdahalli Krishnegowda, Shantu Amin, Iain A. Murray, Arun Sharma
Publikováno v:
Chemical Research in Toxicology. 23:955-966
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, the role of the AHR in normal physiology is still an area of intense investigation. For example
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10f8f91370e714ad49cbd63da729053
https://doi.org/10.1021/tx100045h
https://doi.org/10.1021/tx100045h
Publikováno v:
BJU International. 105:1136-1140
Study Type – Prognosis (case series) Level of Evidence 4 OBJECTIVE To investigate the association of type 2 diabetes mellitus (T2DM) and metabolic syndrome with lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in Taiwanese men aged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63016440da6f014d54b6fc06aa91a1e0
https://doi.org/10.1111/j.1464-410x.2009.08913.x
https://doi.org/10.1111/j.1464-410x.2009.08913.x
Autor:
Kun Ming Chen, Joseph B. Guttenplan, Thomas E. Spratt, Zonglin Zhao, James D. Bortner, Joel L. Schwartz, John P. Richie, Arunangshu Das, Telih Boyiri, Peter G. Sacks, Karam El-Bayoumy, Jyh Ming Lin, Ana Calcagnotto, Shantu Amin
Publikováno v:
Biochemical and Biophysical Research Communications. 383:151-155
Tobacco smoking is an important cause of human oral squamous cell carcinoma (SCC). Tobacco smoke contains multiple carcinogens include polycyclic aromatic hydrocarbons typified by benzo[a]pyrene (B[a]P). Surgery is the conventional treatment approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab520862a85c54ae2043b58ef37b0c7a
https://doi.org/10.1016/j.bbrc.2009.03.145
https://doi.org/10.1016/j.bbrc.2009.03.145