Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Jya-Wei Cheng"'
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The global spread of antibiotic-resistant infections has meant that there is an urgent need to develop new antimicrobial alternatives. In this study, we developed a strategy to boost and/or synergize the activity of conventional antibiotics by combin
Externí odkaz:
https://doaj.org/article/89c61db6db0d4a60b4772107b6b82d23
Autor:
Chih-Lung Wu, Ya-Han Chih, Hsin-Ying Hsieh, Kuang-Li Peng, Yi-Zong Lee, Bak-Sau Yip, Shih-Che Sue, Jya-Wei Cheng
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1351 (2022)
Cecropins are a family of antimicrobial peptides (AMPs) that are widely found in the innate immune system of Cecropia moths. Cecropins exhibit a broad spectrum of antimicrobial and anticancer activities. The structures of Cecropins are composed of 34
Externí odkaz:
https://doaj.org/article/8b9e4f85ae9c43a9b821706969cca2f8
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1097 (2022)
There is an urgent and imminent need to develop new agents to fight against cancer. In addition to the antimicrobial and anti-inflammatory activities, many antimicrobial peptides can bind to and lyse cancer cells. P-113, a 12-amino acid clinically ac
Externí odkaz:
https://doaj.org/article/e0d7d930f0e9440196940bb60c7a93c4
Autor:
Jing-Jing Wang, Walana Williams, Bing Wang, Jing Wei, Xia Lu, Jya-Wei Cheng, John R Gordon, Jing-Min Li, Fang Li
Publikováno v:
International Journal of Ophthalmology, Vol 11, Iss 8, Pp 1277-1283 (2018)
AIM: To investigate the effect of interleukin-8 (IL-8) on neural retinal ganglion cells (RGCs) and whether it can be alleviated by G31P. METHODS: RGC-5 cells were exposed to IL-8 with or without its specific receptor antagonist G31P for 24h, and the
Externí odkaz:
https://doaj.org/article/e19bf66acb0b4b2d98f4af7b66c463af
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background P-113 (AKRHHGYKRKFH-NH2) is a 12-amino-acid histidine-rich peptide derived from histatin 5 that is highly degradable in high salt concentrations and biological fluids such as serum, plasma and saliva. Nal-P-113, a novel antimicrob
Externí odkaz:
https://doaj.org/article/5af27bda97714368b7c80c78f418b07c
Autor:
Hung-Lun Chu, Ya-Han Chih, Kuang-Li Peng, Chih-Lung Wu, Hui-Yuan Yu, Doris Cheng, Yu-Ting Chou, Jya-Wei Cheng
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6810 (2020)
A strategy was described to design antimicrobial peptides (AMPs) with enhanced salt resistance and antiendotoxin activities by linking two helical AMPs with the Ala-Gly-Pro (AGP) hinge. Among the designed peptides, KR12AGPWR6 demonstrated the best an
Externí odkaz:
https://doaj.org/article/b6e13ddbe4724eae98ad8a3a00d677ea
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 13, p 4578 (2020)
There is an urgent and imminent need to develop new antimicrobials to fight against antibiotic-resistant bacterial and fungal strains. In this study, a checkerboard method was used to evaluate the synergistic effects of the antimicrobial peptide P-11
Externí odkaz:
https://doaj.org/article/33c58290101b45ca8778add9184b441a
Autor:
Kuang-Ting Cheng, Chih-Lung Wu, Bak-Sau Yip, Ya-Han Chih, Kuang-Li Peng, Su-Ya Hsu, Hui-Yuan Yu, Jya-Wei Cheng
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2654 (2020)
In the absence of proper immunity, such as in the case of acquired immune deficiency syndrome (AIDS) patients, Candida albicans, the most common human fungal pathogen, may cause mucosal and even life-threatening systemic infections. P-113 (AKRHHGYKRK
Externí odkaz:
https://doaj.org/article/7a865c7d555c437e87676e2bea10d5ce
Autor:
Kuang-Ting Cheng, Chih-Lung Wu, Bak-Sau Yip, Hui-Yuan Yu, Hsi-Tsung Cheng, Ya-Han Chih, Jya-Wei Cheng
Publikováno v:
Molecules, Vol 23, Iss 4, p 800 (2018)
P-113, which was originally derived from the human saliva protein histatin 5, is a histidine-rich antimicrobial peptide with the sequence AKRHHGYKRKFH. P-113 is currently undergoing phase II clinical trial as a pharmaceutical agent to fight against f
Externí odkaz:
https://doaj.org/article/3e461f2bb2c44184a95a59b3d1f2938e
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131240 (2015)
Dengue viruses (DENVs) are members of Flaviviridae family, which are associated with human disease. The envelope (E) protein plays an important role in viral infection. However, there is no effective antibody for clinical treatment due to antibody de
Externí odkaz:
https://doaj.org/article/95708627246240e99092b7c4370badaa