High throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by Methylated DNA sequencing (MeD-seq) of LpnPI digested fragments

Autor: Martijn P. Lolkema, Joost Gribnau, M. M. van der Put, Lindsay Angus, Zakia Azmani, Cees Verhoef, L. F. van Dessel, Stefan Sleijfer, Teoman Deger, Joachim Boers, Saskia M. Wilting, Ruben Boers, Dirk J. Grünhagen, V. de Weerd, Jwm Martens, W F J van IJcken

BackgroundDNA methylation detection in liquid biopsies provides a highly promising and much needed means for real-time monitoring of disease load in advanced cancer patient care. Compared to the often-used somatic mutations, tissue- and cancer-type s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30269831b5e6d5ed57b19a7618da2814
https://doi.org/10.1101/2021.07.12.452012

Abstract P6-19-01: Evaluation of multiple transcriptomic gene risk signatures in male breast cancer

Autor: Jwm Martens, Oliver Bogler, Stéphanie Peeters, C. P. Schroder, EP Winer, Isabel T. Rubio, Barbro Linderholm, Larissa A. Korde, Judith Fraser, C.H.M. van Deurzen, Aleksandra Peric, Ingrid Hedenfalk, C. Poncet, Lavinia P. Middleton, Fatima Cardoso, Carrie Cunningham, Catherine M. Kelly, Joanna Vermeij, Peggy L. Porter, Melissa Murray, Sharon H. Giordano, L. Dal Lago, Cecilia Nilsson, M Nowaczyk, CQ Yao, Monika Sobol, Stefan Aebi, E van Leeuwen-Stok, D van den Weyngaert, T Piper, Jms Bartlett, Kathryn J. Ruddy, Kim Benstead, FH Hilbers, Jane Bayani, C. J. van Asperen, N Anouk, Paul C. Boutros, Cheryl Crozier

Publikováno v: Cancer Research. 79:P6-19

Introduction: Male breast cancer (MBC) is a rare disease accounting for less than 1% of all breast cancers (BC) and 1% of all cancers in males. The clinical management is largely extrapolated from female BC. Several multigene assays are increasingly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faed4d8eae31f535255b8f19b4ade3bc
https://doi.org/10.1158/1538-7445.sabcs18-p6-19-01

Abstract GS1-07: The genomic landscape of 501 metastatic breast cancer patients

Autor: Stefan Sleijfer, Neeltje Steeghs, Jwm Martens, Emile E. Voest, J. van Riet, Martijn P. Lolkema, Saskia M Wilting, Tessa G Steenbruggen, Haiko J. Bloemendal, Mariette Labots, VC Tjan-Heijnen, JM van Riel, A. Jager, Lindsay Angus, H.J.G. van de Werken, Edwin Cuppen, Marcel Smid

Publikováno v: Cancer Research. 79:GS1-07

Background: In depth sequencing of primary breast cancer (BC) has identified a heterogeneous repertoire of disease drivers, evidence of clonal evolution and underlying mutational processes. As cancer evolves over time and under treatment pressure, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0befd148230f72bb6b0bbda61af5b3f6
https://doi.org/10.1158/1538-7445.sabcs18-gs1-07

Interconnectivity between molecular subtypes and tumor stage in colorectal cancer

Autor: Anieta M. Sieuwerts, Jan Paul Medema, R. R. J. Coebergh van den Braak, Marcel Smid, Jan N. M. IJzermans, Jurriaan B. Tuynman, C.J.A. Punt, S. ten Hoorn, Louis Vermeulen, Saskia M. Wilting, John A. Foekens, Jwm Martens

Publikováno v: BMC Cancer, 20(1):850. BioMed Central Ltd.
BMC Cancer, Vol 20, Iss 1, Pp 1-7 (2020)
BMC Cancer
BMC Cancer, 20(1):850. BioMed Central
Coebergh van den Braak, R R J, ten Hoorn, S, Sieuwerts, A M, Tuynman, J B, Smid, M, Wilting, S M, Martens, J W M, Punt, C J A, Foekens, J A, Medema, J P, Ijzermans, J N M & Vermeulen, L 2020, ' Interconnectivity between molecular subtypes and tumor stage in colorectal cancer ', BMC Cancer, vol. 20, no. 1, 850 . https://doi.org/10.1186/s12885-020-07316-z
BMC cancer, 20(1):850. BioMed Central

Background There are profound individual differences in clinical outcomes between colorectal cancers (CRCs) presenting with identical stage of disease. Molecular stratification, in conjunction with the traditional TNM staging, is a promising way to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294945704f74d065767415f7ea25aaa6
https://doi.org/10.1186/s12885-020-07316-z

Abstract P5-23-01: Clinical and biological characterization of male breast cancer (BC) EORTC 10085/TBCRC 029/BOOG 2013-02/BIG 2-07: Baseline results from the prospective registry

Autor: Awg van der Velden, Jms Bartlett, I Bozovic-Spasojevic, MM Vleugel, Nicola S. Russell, Isabel T. Rubio, S Hilsenbeck, Sharon H. Giordano, C. Poncet, Miguel Henriques Abreu, A Wolff, Chm van Deurzen, C. Van Poznak, Barbro Linderholm, Larissa A. Korde, David Cameron, Idm den Hoed, Carolien P. Schröder, N Dijkstra, KJ Ruddy, Aafke H. Honkoop, D Morganstern, Jwm Martens, Fatima Cardoso, K Aalders, Oliver Bogler, Tineke J. Smilde, T Goulioti, M van 't Riet, Konstantinos Tryfonidis, E van Leeuwen-Stok

Publikováno v: Cancer Research. 78:P5-23

BACKGROUND: Through the International Male Breast Cancer Program, a prospective registry for male BC was created with the goals of evaluating 1) the clinical and biological features of this disease and 2) assessing feasibility of a prospective therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::473913f67607b4cfaf3ccb47347e6ef1
https://doi.org/10.1158/1538-7445.sabcs17-p5-23-01