Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors

Autor: Mc, Michel, Jw, Regan, Ma, Gerhardt, Richard Neubig, Pa, Insel, Hj, Motulsky

Publikováno v: Europe PubMed Central

We have recently demonstrated that the alpha 2-adrenergic radioligand [3H]idazoxan also labels additional sites that do not recognize catecholamines but bind with high affinity several chemically distinct drugs previously assumed to be highly selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6c289f3254632cab6880119e356f4c2d
https://pubmed.ncbi.nlm.nih.gov/2153910

Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E 2 by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells.

Autor: Kitagawa K; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Hamaguchi A; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Fukushima K; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Nakano Y; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Regan JW; Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, 85721-0207, USA., Mashimo M; Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, 610-0311, Japan., Fujino H; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan. Electronic address: hfujino@tokushima-u.ac.jp.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2022 Apr 05; Vol. 920, pp. 174863. Date of Electronic Publication: 2022 Feb 28.

The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD 2 or PGE 2 .

Autor: Okura I; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan., Hasuoka N; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Senoo K; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Suganami A; Department of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan., Fukushima K; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Regan JW; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, 85721-0207, USA., Mashimo M; Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Kyoto, 610-0311, Japan., Murayama T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan., Tamura Y; Department of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan. yutaka_tamura@faculty.chiba-u.jp., Fujino H; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan. hfujino@tokushima-u.ac.jp.

Publikováno v: Pharmacological reports : PR [Pharmacol Rep] 2021 Jun; Vol. 73 (3), pp. 946-953. Date of Electronic Publication: 2021 Mar 30.

Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP 4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells.

Autor: Kurata N; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan., Tokashiki N; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Fukushima K; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Misao T; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Hasuoka N; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Kitagawa K; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan., Mashimo M; Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, 610-0311, Japan., Regan JW; Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, 85721-0207, USA., Murayama T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan., Fujino H; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences, Tokushima University, Tokushima, 770-8505, Japan. Electronic address: hfujino@tokushima-u.ac.jp.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2019 Jun 15; Vol. 853, pp. 308-315. Date of Electronic Publication: 2019 Apr 10.

PGE 1 and E 3 show lower efficacies than E 2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors.

Autor: Araki Y; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan., Suganami A; Department of Bioinformatics, Graduate School of Medicine, Chiba University, Japan., Endo S; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan., Masuda Y; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan., Fukushima K; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan., Regan JW; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, USA., Murayama T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan., Tamura Y; Department of Bioinformatics, Graduate School of Medicine, Chiba University, Japan., Fujino H; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan.

Publikováno v: FEBS letters [FEBS Lett] 2017 Nov; Vol. 591 (22), pp. 3771-3780. Date of Electronic Publication: 2017 Nov 12.