Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jw, Kappler"'
Publikováno v:
Europe PubMed Central
It has previously been demonstrated that mature mouse T cells live for many weeks in vivo. In contrast, explanted lymph node or splenic T cells undergo spontaneous death within days, suggesting that survival factors supplied in vivo are not present i
Publikováno v:
Europe PubMed Central
Publikováno v:
Europe PubMed Central
The Staphylococcus aureus enterotoxins are known to be potent T cell activators, stimulating cell proliferation and lymphokine production. Two additional S. aureus proteins, exfoliating toxin and toxic shock syndrome toxin, share these properties. Re
Autor:
Philippa Marrack, Jw, Kappler
Publikováno v:
Europe PubMed Central
Publikováno v:
Europe PubMed Central
A 17-amino acid tryptic peptide of chicken ovalbumin, designated P323-339, that substituted for processed antigen when presented by glutaraldehyde prefixed accessory cells to specific I-restricted T hybridomas was characterized. The peptide antigen c
Publikováno v:
Europe PubMed Central
KJ23a+ T cell clones, which bear the determinant encoded by the V beta 17a T cell receptor gene segment, frequently recognize IE molecules of various murine H-2 haplotypes. In the presence of IE molecules, thymic maturation of KJ23a+ clones is infreq
Publikováno v:
Europe PubMed Central
Research on the specificities, functions, and maturation of T cells would be greatly aided by a collection of monoclonal antibodies which distinguishes different types of TCR. With this end in mind hamsters were immunized and tested for production of
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2010 May 01; Vol. 184 (9), pp. 4592-5.
Publikováno v:
Europe PubMed Central
The TCR alpha/beta variable element V beta 17a is expressed in all strains of mice carrying the V beta a complex in which about half of the V beta elements have been lost due to a large deletion. The mAb KJ23a detects V beta 17a containing alpha/beta
Publikováno v:
Europe PubMed Central
We determined if self-reactive T cells are able to escape thymic tolerance in autoimmune New Zealand mice. T cells utilizing V beta 17a and V beta 11 encoded receptors have been shown to be clonally eliminated in nonautoimmune mice expressing I-E bec