Výsledky vyhledávání

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice

Autor: Pa, Burns, Cj, Kemp, Jv, Gannon, Dp, Lane, Rod Bremner, Balmain A

Publikováno v: Europe PubMed Central

Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model systems would greatly facilitate the detection and manipulation of such genes. We describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7863b4f9ae1cc55dd31ac9dfea287444
http://europepmc.org/abstract/med/1766680

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Host proteins that bind to or mimic SV40 large T antigen: using antibodies to look at protein interactions and their significance

Autor: Sara Mole, Jv, Gannon, Ia, Anton, Mj, Ford, Dp, Lane

Publikováno v: Europe PubMed Central

The papovavirus SV40 is able to induce tumours in susceptible hosts and will transform cells in vitro. Its major early protein, large T antigen, is required for viral DNA synthesis, both in vivo and in vitro, and is also responsible for the oncogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::59ed0ef369376337b67ed16b763e27fb
http://europepmc.org/abstract/med/2478459

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Akademický článek

A measure of the mitotic index: studies of the abundance and half-life of p34cdc2 in cultured cells and normal and neoplastic tissues.

Autor: Gannon JV; ICRF Laboratories, South Mimms, Herts, UK., Nebreda A, Goodger NM, Morgan PR, Hunt T

Publikováno v: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 1998 Jan; Vol. 3 (1), pp. 17-27.

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Akademický článek

Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.

Autor: Nebreda AR; ICRF Clare Hall Laboratories, South Mimms, Herts, UK., Gannon JV, Hunt T

Publikováno v: The EMBO journal [EMBO J] 1995 Nov 15; Vol. 14 (22), pp. 5597-607.

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Akademický článek

Simian virus 40 large T antigen associates with cyclin A and p33cdk2.

Autor: Adamczewski JP; ICRF Clare Hall Laboratories, South Mimms, Herts, England., Gannon JV, Hunt T

Publikováno v: Journal of virology [J Virol] 1993 Nov; Vol. 67 (11), pp. 6551-7.

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Akademický článek

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

Autor: Burns PA; Beatson Institute for Cancer Research, Glasgow, UK., Kemp CJ, Gannon JV, Lane DP, Bremner R, Balmain A

Publikováno v: Oncogene [Oncogene] 1991 Dec; Vol. 6 (12), pp. 2363-9.

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Akademický článek

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

Autor: Bártek J; Department of Immunology and Molecular Biology, Masaryk Institute of Oncology, Brno, Czechoslovakia., Bártková J, Vojtĕsek B, Stasková Z, Lukás J, Rejthar A, Kovarík J, Midgley CA, Gannon JV, Lane DP

Publikováno v: Oncogene [Oncogene] 1991 Sep; Vol. 6 (9), pp. 1699-703.

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Akademický článek

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport.

Autor: Gannon JV; Imperial Cancer Research Fund, Clare Hall Laboratories, Potters Bar, Herts, UK., Lane DP

Publikováno v: Nature [Nature] 1991 Feb 28; Vol. 349 (6312), pp. 802-6.

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Akademický článek

p53 mutations in colorectal cancer.

Autor: Rodrigues NR; Director's Laboratory, Imperial Cancer Research Fund, Lincolns Inn Fields, London, United Kingdom., Rowan A, Smith ME, Kerr IB, Bodmer WF, Gannon JV, Lane DP

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1990 Oct; Vol. 87 (19), pp. 7555-9.

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