Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

Autor: Suijker J, Oosting J, Koornneef A, Ea, Struys, Gs, Salomons, Fg, Schaap, Cathelijn Waaijer, Pm, Wijers-Koster, Ih, Briaire-De Bruijn, Haazen L, Sm, Riester, Dudakovic A, Danen E, Am, Cleton-Jansen, Aj, Wijnen, Jv, Bovée

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8b63814c53fa796732c951c3f78c18bb
http://europepmc.org/abstract/med/25895133

Loss of NF2 defines a genetic subgroup of non-FOS-rearranged osteoblastoma.

Autor: Saba KH; Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden., Cornmark L; Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden., Hofvander J; Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden., Magnusson L; Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden., Nilsson J; Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden., van den Bos H; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Spierings DC; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Staaf J; Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden., Brosjö O; Department of Orthopedics, Karolinska University Hospital, Stockholm, Sweden., Sumathi VP; Department of Musculoskeletal Pathology, Royal Orthopaedic Hospital, Birmingham, UK., Lam SW; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Szuhai K; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Bovée JV; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Kovac M; Bone Tumour Reference Centre at the Institute of Pathology, University Hospital and University of Basel, Basel, Switzerland., Baumhoer D; Bone Tumour Reference Centre at the Institute of Pathology, University Hospital and University of Basel, Basel, Switzerland., Styring E; Department of Orthopedics, Lund University, Skåne University Hospital, Lund, Sweden., Nord KH; Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden.

Publikováno v: The journal of pathology. Clinical research [J Pathol Clin Res] 2020 Oct; Vol. 6 (4), pp. 231-237. Date of Electronic Publication: 2020 Jun 16.

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy.

Autor: Luk SJ; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., van der Steen DM; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Hagedoorn RS; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Jordanova ES; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.; Center for Gynecological Oncology Amsterdam, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands., Schilham MW; Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands., Bovée JV; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Cleven AH; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Falkenburg JF; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Szuhai K; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands., Heemskerk MH; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Oncoimmunology [Oncoimmunology] 2018 Sep 11; Vol. 7 (12), pp. e1507600. Date of Electronic Publication: 2018 Sep 11 (Print Publication: 2018).

Immune checkpoint inhibitors in sarcomas: in quest of predictive biomarkers.

Autor: Veenstra R; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Kostine M; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Cleton-Jansen AM; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., de Miranda NF; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Bovée JV; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2018 Jan; Vol. 98 (1), pp. 41-50. Date of Electronic Publication: 2017 Nov 20.

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.

Autor: Ratcliffe P; Target Discovery Institute, University of Oxford; The Francis Crick Institute, London, UK., Koivunen P; Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Myllyharju J; Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Ragoussis J; McGill University and Genome Quebec Innovation Centre, McGill University, Montreal, Canada., Bovée JV; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands., Batinic-Haberle I; Department of Radiation Oncology, Duke University School of Medicine, Durham, NC, USA., Vinatier C; INSERM UMR 1229, Regenerative Medicine and Skeleton-RMeS, Team STEP, University of Nantes, UFR Odontology., Trichet V; UMR 1238 INSERM, Université de Nantes, Faculté de Médecine., Robriquet F; CRCINA, INSERM, Université de Nantes, Nantes., Oliver L; CRCINA, INSERM, Université de Nantes, Nantes., Gardie B; CRCINA, INSERM, Université de Nantes, Nantes; Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France.

Publikováno v: Hypoxia (Auckland, N.Z.) [Hypoxia (Auckl)] 2017 Mar 15; Vol. 5, pp. 11-20. Date of Electronic Publication: 2017 Mar 15 (Print Publication: 2017).