Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Juvvadi, P"'
Autor:
Bikash Parida, Satya Sundar Gajendra Mohapatra, Sumita Swain, Kaushik Rao Juvvadi, Somadatta Das
Publikováno v:
JK Science, Vol 26, Iss 2 (2024)
Background: Years after SARS recovery, residual pulmonary abnormalities may still exist. This raises the question of whether or not Covid-19 could have comparable late consequences. Structural changes in the Lungs after recovery can be better visuali
Externí odkaz:
https://doaj.org/article/1c6f3379afe840839fb23e7f77aa3fc2
Publikováno v:
Journal of Neuroanaesthesiology and Critical Care, Vol 10, Iss 02, Pp 128-131 (2023)
Guillain-Barre syndrome (GBS) is one of the common causes for acute flaccid paralysis in adults and mostly preceded by infection. Miller Fisher syndrome (MFS) is a rare variant of GBS with incidence of 1 to 2 in 1,000,000. This syndrome has a triad o
Externí odkaz:
https://doaj.org/article/56fcf23063fd4c898f92e4410b4020e0
Autor:
Angela Rivera, Won Young Lim, Eunchong Park, Patrick A. Dome, Michael J. Hoy, Ivan Spasojevic, Sheng Sun, Anna Floyd Averette, Sergio Pina-Oviedo, Praveen R. Juvvadi, William J. Steinbach, Maria Ciofani, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Fungal infections are of mounting global concern, and the current limited treatment arsenal poses challenges when treating such infections. In particular, infections by Cryptococcus neoformans are associated with high mortality, emphasizing
Externí odkaz:
https://doaj.org/article/ce0b324bccb346759ee1b133f5211833
Autor:
Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Calcineurin is an essential virulence factor that is conserved across human fungal pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans. Although an excellent target for antifungal drug development, the s
Externí odkaz:
https://doaj.org/article/117f01418524456e8457bbd3d23cdecf
Akademický článek
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Autor:
Sophie M.-C. Gobeil, Benjamin G. Bobay, Praveen R. Juvvadi, D. Christopher Cole, Joseph Heitman, William J. Steinbach, Ronald A. Venters, Leonard D. Spicer
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so e
Externí odkaz:
https://doaj.org/article/0963e345cfb74f47bf957fdadaef28c6
Publikováno v:
Journal of Fungi, Vol 8, Iss 12, p 1281 (2022)
Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens. The immunosuppressive drugs, tacrolimus (FK506) and cyclosporin A (CsA), are fungistatic and specif
Externí odkaz:
https://doaj.org/article/6872ee6340a742b0881e3265c8ffab07
Autor:
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less imm
Externí odkaz:
https://doaj.org/article/4b8d65315776423982c1bea6612cead9
Akademický článek
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Autor:
E. Keats Shwab, Praveen R. Juvvadi, Greg Waitt, Shareef Shaheen, John Allen, Erik J. Soderblom, Benjamin G. Bobay, Yohannes G. Asfaw, M. Arthur Moseley, William J. Steinbach
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism. The fungus Aspergillus fumigatus is a leading infectious ca
Externí odkaz:
https://doaj.org/article/3ece9604418c42c0a8b4f8936774ea35