Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Juvid, Aryaman"'
Autor:
Mikael G. Pezet, Aurora Gomez-Duran, Florian Klimm, Juvid Aryaman, Stephen Burr, Wei Wei, Mitinori Saitou, Julien Prudent, Patrick F. Chinnery
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Using an in vitro culture system, Pezet et al. studied the influence of oxygen on the mitochondrial DNA (mtDNA) in primordial germ cell-like cells (PGCLCs) in vitro. Low oxygen levels resembling in vivo reduced the cell mtDNA content causing a geneti
Externí odkaz:
https://doaj.org/article/2ddd821695224939802015f7ff5f8b03
Autor:
Michael J. Keogh, Wei Wei, Juvid Aryaman, Lauren Walker, Jelle van den Ameele, Jon Coxhead, Ian Wilson, Matthew Bashton, Jon Beck, John West, Richard Chen, Christian Haudenschild, Gabor Bartha, Shujun Luo, Chris M. Morris, Nick S. Jones, Johannes Attems, Patrick F. Chinnery
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Similar to cancers, somatic mutations might lead to neurodegenerative diseases. Here, the authors perform ultra-deep sequencing of 102 genes in 173 adult human brains, detect somatic mutations in 54 brains, and develop a mathematical model to estimat
Externí odkaz:
https://doaj.org/article/4340dcba8f0b45e0b3cd339e05e6fd88
Publikováno v:
Frontiers in Genetics, Vol 9 (2019)
Cell-to-cell heterogeneity drives a range of (patho)physiologically important phenomena, such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly of mitochondria, is increasingly being recognized as an important exp
Externí odkaz:
https://doaj.org/article/57eedd4176c2419bbd741384d19501e2
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
The expansion of mitochondrial DNA molecules with deletions has been associated with aging, particularly in skeletal muscle fibers; its mechanism has remained unclear for three decades. Previous accounts have assigned a replicative advantage (RA) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ec1ddec6ab94b0a25a145df2406c14
https://pubmed.ncbi.nlm.nih.gov/36442091
https://pubmed.ncbi.nlm.nih.gov/36442091
Autor:
Haixin Zhang, Marco Esposito, Mikael G. Pezet, Juvid Aryaman, Wei Wei, Florian Klimm, Claudia Calabrese, Stephen P. Burr, Carolina H. Macabelli, Carlo Viscomi, Mitinori Saitou, Marcos R. Chiaratti, James B. Stewart, Nick Jones, Patrick F. Chinnery
Publikováno v:
Sci Adv
Science Advances
Science Advances
Description
Single-cell analysis of mouse oocytes implicates the preferential transmission of a pathogenic mitochondrial DNA (mtDNA) mutation.
Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a
Single-cell analysis of mouse oocytes implicates the preferential transmission of a pathogenic mitochondrial DNA (mtDNA) mutation.
Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a9ff27a2ee844a9756e003ff345aa7
http://hdl.handle.net/10044/1/93484
http://hdl.handle.net/10044/1/93484
Autor:
Aurora Gomez-Duran, Mikael G. Pezet, Stephen P. Burr, Julien Prudent, Patrick F. Chinnery, Mitinori Saitou, Juvid Aryaman, Wei Wei, Florian Klimm
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology
Most humans carry a mixed population of mitochondrial DNA (mtDNA heteroplasmy) affecting ~1–2% of molecules, but rapid percentage shifts occur over one generation leading to severe mitochondrial diseases. A decrease in the amount of mtDNA within th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724cd215bb7443a569d303f4cc5b6980
The expansion of deleted mitochondrial DNA molecules has been associated with ageing 1,2, particularly in skeletal muscle fibres 3–5; its mechanism has remained unclear for three decades. Previous accounts have assigned a replicative advantage to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa705d9610f189eb41370655a83b2195
https://doi.org/10.1101/2020.09.01.277137
https://doi.org/10.1101/2020.09.01.277137
Publikováno v:
Frontiers in Genetics
Cell-to-cell heterogeneity drives a range of (patho)physiologically important phenomena, such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly of mitochondria, is increasingly being recognized as an important exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb2bd133fb0056e3b590f069deaaa287
https://pubmed.ncbi.nlm.nih.gov/30740126
https://pubmed.ncbi.nlm.nih.gov/30740126
Publikováno v:
Genetics
Mitochondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with healthy aging. MtDNA is stochastically replicated and degraded, and exists within organelles which undergo dynamic fusion and fission. The role of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb4d60fdd1a92d05fecc5a338f0485e
Publikováno v:
Biochemical Journal
Mitochondrial dysfunction is involved in a wide array of devastating diseases, but the heterogeneity and complexity of the symptoms of these diseases challenges theoretical understanding of their causation. With the explosion of omics data, we have t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72a81fae700823e170b0077482dfb973
https://pubmed.ncbi.nlm.nih.gov/29079678
https://pubmed.ncbi.nlm.nih.gov/29079678