Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis

Autor: Shankar, S, Stolp, J, Juvet, SC, Beckett, J, Macklin, PS, Issa, F, Hester, J, Wood, KJ

Publikováno v: Nature Communications. 13

Regulatory B cells (Breg) are a heterogenous population with immune-modulating functions. The rarity of human IL-10+ Breg makes translational studies difficult. Here we report ex vivo expansion of human B cells with in vivo regulatory function (expBr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d30f46479af1ad778a3415eda75dfc3
https://doi.org/10.1038/s41467-022-30613-z

Unlocking the potential of RNA-based therapeutics in the lung: current status and future directions.

Autor: Man HSJ; Temerty Faculty of Medicine, Institute of Medical Science, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, Toronto, ON, Canada.; Division of Respirology and Critical Care Medicine, Department of Medicine, University Health Network, Toronto, ON, Canada., Moosa VA; Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, Toronto, ON, Canada.; Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON, Canada., Singh A; Thoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., Wu L; Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, Toronto, ON, Canada.; Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON, Canada., Granton JT; Division of Respirology and Critical Care Medicine, Department of Medicine, University Health Network, Toronto, ON, Canada., Juvet SC; Temerty Faculty of Medicine, Institute of Medical Science, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, Toronto, ON, Canada.; Division of Respirology and Critical Care Medicine, Department of Medicine, University Health Network, Toronto, ON, Canada., Hoang CD; Thoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., de Perrot M; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, Toronto, ON, Canada.; Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON, Canada.

Publikováno v: Frontiers in genetics [Front Genet] 2023 Nov 23; Vol. 14, pp. 1281538. Date of Electronic Publication: 2023 Nov 23 (Print Publication: 2023).

Robust segregation of donor and recipient cells from single-cell RNA-sequencing of transplant samples.

Autor: Wilson GW; Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada., Duong A; Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada., Moshkelgosha S; Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada., Bader G; The Donnelly Centre, University of Toronto, Toronto, ON, Canada., Keshavjee S; Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada.; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada., Martinu T; Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada.; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada., Juvet SC; Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada.; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada., Yeung JC; Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada.; Toronto Lung Transplant Program, Toronto General Hospital, Toronto, ON, Canada.

Publikováno v: Frontiers in transplantation [Front Transplant] 2023 Jun 12; Vol. 2, pp. 1161146. Date of Electronic Publication: 2023 Jun 12 (Print Publication: 2023).

Donor and recipient human leukocyte antigen-G polymorphisms modulate the risk of adverse immunologic events following lung transplantation.

Autor: Riddell P; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Ma J; Biostatistics Research Unit, University Health Network, University of Toronto, Toronto, Canada., Lazarte J; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada., Birriel D; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Ulahannan A; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Ghany R; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Delgado D; Heart Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Rao V; Heart Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Keshavjee S; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Martinu T; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Tikkanen J; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada., Juvet SC; Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Canada. Electronic address: stephen.juvet@uhn.ca.

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2023 Mar; Vol. 23 (3), pp. 393-400. Date of Electronic Publication: 2023 Jan 04.

A biomarker assay to risk-stratify patients with symptoms of respiratory tract infection.

Autor: Husain S; Division of Infectious Diseases, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Sage AT; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Del Sorbo L; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada.; Interdepartmental Division of Critical Care Medicine, Medical and Surgical Intensive Care Unit, University Health Network, University of Toronto, Toronto, ON, Canada., Cypel M; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada., Martinu T; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada., Juvet SC; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada., Mariscal A; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Wright J; Tropical Disease Unit, Department of Medicine, University of Toronto, Sandra Rotman Centre for Global Health, University Health Network, Toronto General Hospital, Toronto, ON, Canada., Chao BT; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada., Shamandy AA; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada., Mousavi SH; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada., Ma J; Biostatistics Research Unit, University Health Network, Toronto, ON, Canada., Wang B; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Vector Institute, Toronto, ON, Canada., Valero J; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Liu M; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Landes M; Department of Emergency Medicine, University Health Network, Toronto, ON, Canada.; Division of Emergency Medicine, Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada., Balachandran S; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Hudson K; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada., Ngai M; Tropical Disease Unit, Department of Medicine, University of Toronto, Sandra Rotman Centre for Global Health, University Health Network, Toronto General Hospital, Toronto, ON, Canada., Capuano M; Division of Emergency Medicine and High Dependency Unit, Cittá della Salute e della Scienza di Torino Hospital-Molinette Site, Department of Medical Sciences, University of Turin, Turin, Italy., Gelardi M; Division of Emergency Medicine and High Dependency Unit, Cittá della Salute e della Scienza di Torino Hospital-Molinette Site, Department of Medical Sciences, University of Turin, Turin, Italy., Lupia E; Division of Emergency Medicine and High Dependency Unit, Cittá della Salute e della Scienza di Torino Hospital-Molinette Site, Department of Medical Sciences, University of Turin, Turin, Italy., Marinowic DR; School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Friedrich FO; School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Schmitz CRR; Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Dos Santos LSM; School of Health, Sciences and Life, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Barbe-Tuana FM; School of Health, Sciences and Life, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Jones MH; School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Kain KC; Tropical Disease Unit, Department of Medicine, University of Toronto, Sandra Rotman Centre for Global Health, University Health Network, Toronto General Hospital, Toronto, ON, Canada., Mazzulli T; Department of Microbiology, Mount Sinai Hospital, Toronto, ON, Canada., Sabbah S; Department of Emergency Medicine, University Health Network, Toronto, ON, Canada.; Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada., Keshavjee S; Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada shaf.keshavjee@uhn.ca.; Ajmera Transplant Centre, University Health Network, University of Toronto, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Division of Thoracic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Publikováno v: The European respiratory journal [Eur Respir J] 2022 Dec 15; Vol. 60 (6). Date of Electronic Publication: 2022 Dec 15 (Print Publication: 2022).