Tetrazine Glycoconjugate for Pretargeted Positron Emission Tomography Imaging of trans-Cyclooctene-Functionalized Molecular Spherical Nucleic Acids

Autor: Tatsiana Auchynnikava, Antti Äärelä, Heidi Liljenbäck, Juulia Järvinen, Putri Andriana, Luciana Kovacs, Jarkko Rautio, Johan Rajander, Pasi Virta, Anne Roivainen, Xiang-Guo Li, Anu J. Airaksinen

Publikováno v: ACS Omega, Vol 8, Iss 48, Pp 45326-45336 (2023)

Externí odkaz: https://doaj.org/article/3e6295ea4662448287917705d70fe616

Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma

Autor: Tarapong Srisongkram, Katayun Bahrami, Juulia Järvinen, Juri Timonen, Jarkko Rautio, Natthida Weerapreeyakul

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 15, p 8446 (2022)

Sesamol is a compound reported to have anti-melanogenesis and anti-melanoma actions. Sesamol, however, has low intracellular drug concentration and fast excretion, which can limit its benefits in the clinic. To overcome this drawback and increase int

Externí odkaz: https://doaj.org/article/5d486ff149a142d0837509d7012738af

Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

Autor: Piman Pocasap, Natthida Weerapreeyakul, Juri Timonen, Juulia Järvinen, Jukka Leppänen, Jussi Kärkkäinen, Jarkko Rautio

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6, p 2132 (2020)

l-type amino acid transporter 1 (LAT1) is an amino acid transporter that is overexpressed in several types of cancer and, thus, it can be a potential target for chemotherapy. The objectives of this study were to (a) synthesize LAT1-targeted chlorambu

Externí odkaz: https://doaj.org/article/99f48a856ca942cdb0a3e5dd359a4122

Synthesis and

Autor: Jelena, Matović, Juulia, Järvinen, Iris K, Sokka, Philipp, Stockmann, Martin, Kellert, Surachet, Imlimthan, Mirkka, Sarparanta, Mikael P, Johansson, Evamarie, Hey-Hawkins, Jarkko, Rautio, Filip S, Ekholm

Publikováno v: ACS omega. 7(34)

Glucose- and sodium-dependent glucose transporters (GLUTs and SGLTs) play vital roles in human biology. Of the 14 GLUTs and 12 SGLTs, the GLUT1 transporter has gained the most widespread recognition because GLUT1 is overexpressed in several cancers a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::605ee06346d03ebe3fa17fea2d7cda23
https://pubmed.ncbi.nlm.nih.gov/36061667

Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates

Autor: Jan-Erik Raitanen, Mikael P. Johansson, Juulia Järvinen, Jarkko Rautio, Surachet Imlimthan, Hannu Maaheimo, Anu J. Airaksinen, Sirpa Peräniemi, Jelena Matovic, Ahmed Montaser, Iris Katariina Sokka, Mirkka Sarparanta, Kristiina M. Huttunen, Filip S. Ekholm

Publikováno v: Matović, J, Järvinen, J, Sokka, I K, Imlimthan, S, Raitanen, J E, Montaser, A, Maaheimo, H, Huttunen, K M, Peräniemi, S, Airaksinen, A J, Sarparanta, M, Johansson, M P, Rautio, J & Ekholm, F S 2021, ' Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT : Chemical Synthesis and in Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates ', Molecular Pharmaceutics, vol. 18, no. 1, pp. 285-304 . https://doi.org/10.1021/acs.molpharmaceut.0c00917

Boron neutron capture therapy (BNCT) is a noninvasive binary therapeutic modality applicable to the treatment of cancers. While BNCT offers a tumor-targeting selectivity that is difficult to match by other means, the last obstacles preventing the ful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4ebd61d3f900e8c6d0656aebc158ac
http://hdl.handle.net/10138/340053