Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Jutta Rohrbacher"'
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Akademický článek
The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose
Autor: Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman, David J. Gallacher
Publikováno v: Biomolecules, Vol 13, Iss 9, p 1355 (2023)
Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported. We evaluated loperamide in in vitro and in vivo cardiac
Externí odkaz: https://doaj.org/article/c7cdd87a46974314ad2466c9c4b2542c
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2
Akademický článek
Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
Autor: Elisa Passini, Oliver J. Britton, Hua Rong Lu, Jutta Rohrbacher, An N. Hermans, David J. Gallacher, Robert J. H. Greig, Alfonso Bueno-Orovio, Blanca Rodriguez
Publikováno v: Frontiers in Physiology, Vol 8 (2017)
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy in clinical risk prediction. Human-based computer models constitute a fast, cheap and pote
Externí odkaz: https://doaj.org/article/e99a42ad86a2401cb87ae68c3079f894
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7
Sustained synchronized neuronal network activity in a human astrocyte co-culture system
Autor: Winnok H. De Vos, Theo Meert, Miroslav Cik, Jacobine Kuijlaars, Peter Verstraelen, Pieter J. Peeters, An Verheyen, Bert Brône, Annick Diels, Marlies Verschuuren, Marianne Tuefferd, Rony Nuydens, Tutu Oyelami, Sofie Versweyveld, Jan R. Detrez, Jutta Rohrbacher, Giulia Meneghello
Publikováno v: Scientific Reports
Scientific reports
SCIENTIFIC REPORTS
Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative disorders such as autism, schizophrenia, and Alzheimer's disease and is typically studied using genetically modified cellular and animal models. Weak predict
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61aded235a5dd0895bef8a06ba5133b
http://hdl.handle.net/1942/22813
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8
Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2
Autor: Rob Towart, G McIntyre, Hua Rong Lu, Michael K. Pugsley, G Eichenbaum, JM Davenport, Jutta Rohrbacher, U Shukla, David J. Gallacher, V Hillsamer
Publikováno v: British Journal of Pharmacology. 166:1694-1707
BACKGROUND AND PURPOSE JNJ-Q2, a novel broad-spectrum fluoroquinolone with anti-methicillin-resistant Staphylococcus aureus activity, was evaluated in a comprehensive set of non-clinical and clinical cardiovascular safety studies. The effect of JNJ-Q
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a77b35e94561eb88b03b747dd06a9c0
https://doi.org/10.1111/j.1476-5381.2012.01874.x
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10
Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the ‘bad’ sodium current blockers
Autor: Karel Van Ammel, Gan-Xin Yan, Hua Rong Lu, Eddy Vlaminckx, David J. Gallacher, Jutta Rohrbacher
Publikováno v: British Journal of Pharmacology. 160:60-76
Background and purpose: The regulatory guidelines (ICHS7B) for the identification of only drug-induced long QT and pro-arrhythmias have certain limitations. Experimental approach: Conduction time (CT) was measured in isolated Purkinje fibres, left ve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4100c56b9d57571883858a18c6cf0a71
https://doi.org/10.1111/j.1476-5381.2010.00646.x
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