Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jutta Dr Hansen"'
Autor:
Helga Rübsamen-Waigmann, Jutta Mässen, Elisabeth Schmidt, Uwe Gottschalk, Jutta Dr Hansen, Heiner Apeler, Karl-Heinz Schneider, Marcus Schneidereit, Diana Guntermann
Publikováno v:
European Journal of Biochemistry. 247:890-895
An attractive target for anti-herpes chemotherapy is the herpes simplex virus 1 (HSV-1) protease encoded by the UL26 gene. Studies with HSV-1 strains that harbour mutations in the protease gene have demonstrated that the protease is essential for DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad9a0eea3373663a8243cf4d513f430
https://doi.org/10.1111/j.1432-1033.1997.t01-1-00890.x
https://doi.org/10.1111/j.1432-1033.1997.t01-1-00890.x
Autor:
Anusch Peyman, Karl-Heinz Budt, Jutta Dr Hansen, Ruppert Dieter, Arno Paessens, Christoph Dr. Meichsner, Bernd Stowasser, Jochen Knolle
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:559-571
A detailed structure-activity relationship of C 2 -symmetric diol inhibitors of HIV-1 protease leads to inhibitor 6 (HOE/BAY 793) which is outstanding in the inhibition of the enzyme and in the inhibition of viral replication in HIV infected cell cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63be7354aed17c968a5fc362384a529c
https://doi.org/10.1016/0968-0896(95)00069-s
https://doi.org/10.1016/0968-0896(95)00069-s
Autor:
Gerhard Breipohl, Wolfram Schäfer, Hans J. Schramm, Christoph Dr. Meichsner, Stephan Dr Henke, Wolfgang Schramm, Ernst Jaeger, Karl-Peter Rücknagel, Dieter Ruppert, Jutta Dr Hansen, Günther Rieß
Publikováno v:
Biochemical and Biophysical Research Communications. 184:980-985
The active HIV-1 protease is a homodimeric enzyme. A beta-sheet consisting of N- and C-terminal segments provides the main driving force for dimerization of the inactive protomers. Several short peptides with sequences derived from the N- and C-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ec1a7af4d4189af73e339636b6cd05
https://doi.org/10.1016/0006-291x(92)90687-g
https://doi.org/10.1016/0006-291x(92)90687-g
Autor:
Anusch Peyman, Jutta Dr Hansen, K.‐H. Budt, Jörg Spanig, Irvin Winkler, D. Ruppert, J. Knolle, C. Meichsner, Arnold Dr. Paessens, Bernd Stowasser, L. Jian-Qi
Publisher Summary This chapter describes a series of inhibitors in which a central building block, containing a transition-state mimetic and the P1 and P1’ residues of the HIV-PR cleavage site, is placed in a C 2 -symmetrical peptidic environment a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c2b2a60e7d427e044faac8f52112c2
https://doi.org/10.1016/s0165-7208(97)80081-5
https://doi.org/10.1016/s0165-7208(97)80081-5
