Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

Autor: Florian J Groelly, Manuela Porru, Jutta Zimmer, Hugo Benainous, Yanti De Visser, Anastasiya A Kosova, Serena Di Vito, Violeta Serra, Anderson Ryan, Carlo Leonetti, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-22 (2022)

Abstract The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to replication‐associated DNA damage and genomic instability, a signature of BRCA1/2‐mutated tumours. Targeted therapies again

Externí odkaz: https://doaj.org/article/02c619b0acf544c3b51f32c37322ca42

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Autor: Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, Madalena Tarsounas

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA s

Externí odkaz: https://doaj.org/article/a8a9dca4e29c43adad08bdc9e4343805

Genomic instability in patients with sex determination defects and germ cell cancer

Autor: Maria Krivega, Jutta Zimmer, Anna Slezko, Petra Frank-Herrmann, Julia Rehnitz, Markus Hohenfellner, Markus Bettendorf, Marcin Luzarowski, Thomas Strowitzki

The ability to transmit genetic information through generations depends on preservation of genome integrity. Genetic abnormalities affect cell differentiation, causing tissue specification defects and cancer. We addressed genomic instability in indiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7ef637122d5e396447baadeccc0b60a
https://doi.org/10.1101/2022.06.08.495249

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Autor: Wojciech Niedzwiedz, Sophie Badie, Xianning Lai, Ronan Broderick, Jutta Zimmer, Valérie Bergoglio, Madalena Tarsounas, Jean-Sébastien Hoffmann

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/ncomms15983⟩
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Failure to restart replication forks stalled at genomic regions that are difficult to replicate or contain endogenous DNA lesions is a hallmark of BRCA2 deficiency. The nucleolytic activity of MUS81 endonuclease is required for replication fork resta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20187f9bb369ab14c0a03cb6222ee495
https://hal.archives-ouvertes.fr/hal-02325713

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

Autor: Jutta, Zimmer, Eliana M C, Tacconi, Cecilia, Folio, Sophie, Badie, Manuela, Porru, Kerstin, Klare, Manuela, Tumiati, Enni, Markkanen, Swagata, Halder, Anderson, Ryan, Stephen P, Jackson, Kristijan, Ramadan, Sergey G, Kuznetsov, Annamaria, Biroccio, Julian E, Sale, Madalena, Tarsounas

Publikováno v: Molecular Cell

Summary G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c7cfbefbdb30f2e35eaad021b8a9a7a
https://pubmed.ncbi.nlm.nih.gov/26748828