Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jutta, Siegrist"'
Autor:
Max Cárdenas-Fernández, Jutta Siegrist, Fabiana Subrizi, Jennifer N. Andexer, Rebecca Roddan, Yu Wang, Daniel Méndez-Sánchez, Helen C. Hailes, John M. Ward, Benjamin Thair, Michael Richter
Publikováno v:
Angewandte Chemie (International Ed. in English)
The tetrahydroisoquinoline (THIQ) ring system is present in a large variety of structurally diverse natural products exhibiting a wide range of biological activities. Routes to mimic the biosynthetic pathways to such alkaloids, by building cascade re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5606bb0f767d452b26da3825034360c0
https://doi.org/10.1002/ange.202104476
https://doi.org/10.1002/ange.202104476
Autor:
Silja Mordhorst, Michael Müller, Michael Richter, Jutta Siegrist, Jun. Prof. Dr. Jennifer N. Andexer
Publikováno v:
Angewandte Chemie. 129:4095-4099
S-Adenosylmethionine-dependent methyltransferases are versatile tools for the specific alkylation of many compounds, such as pharmaceuticals, but their biocatalytic application is severely limited owing to the lack of a cofactor regeneration system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a48b6225a0ab79fd71fb5bdb17711d8
https://doi.org/10.1002/ange.201611038
https://doi.org/10.1002/ange.201611038
Autor:
Stefan Gerhardt, Jutta Siegrist, Jennifer N. Andexer, Oliver Einsle, Silja Mordhorst, Lukas Karst, Julia Netzer, Michael Richter
Publikováno v:
FEBS Letters. 591:312-321
Mg2+ -dependent catechol-O-methyltransferases occur in animals as well as in bacteria, fungi and plants, often with a pronounced selectivity towards one of the substrate's hydroxyl groups. Here, we show that the bacterial MxSafC exhibits excellent re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a6220a03909ef62e32919cae9c9cf3
https://doi.org/10.1002/1873-3468.12530
https://doi.org/10.1002/1873-3468.12530
Autor:
Jutta Siegrist, Silja Mordhorst, Jennifer N. Andexer, Michael Richter, Simon Aschwanden, Linda Thöny-Meyer
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(18)
S-Adenosylmethionine (SAM)-dependent enzymes have great potential for selective alkylation processes. In this study we investigated the regiocomplementary O-methylation of catechols. Enzymatic methylation is often hampered by the need for a stoichiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9299c5b9000a00e90adc2e69569b7f6
https://pubmed.ncbi.nlm.nih.gov/26437744
https://pubmed.ncbi.nlm.nih.gov/26437744
Autor:
Julia, Schlesier, Jutta, Siegrist, Stefan, Gerhardt, Annette, Erb, Simone, Blaesi, Michael, Richter, Oliver, Einsle, Jennifer N, Andexer
Publikováno v:
BMC Structural Biology
Background Methionine adenosyltransferases catalyse the synthesis of S-adenosylmethionine, a cofactor abundant in all domains of life. In contrast to the enzymes from bacteria and eukarya that show high sequence similarity, methionine adenosyltransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbba9ad08085d48dff0ff40bc310b573
https://pubmed.ncbi.nlm.nih.gov/24134203
https://pubmed.ncbi.nlm.nih.gov/24134203
Autor:
Jennifer N. Andexer, Jutta Siegrist, Simon Aschwanden, Michael Richter, Linda Thöny-Meyer, Silja Mordhorst
Publikováno v:
ChemBioChem. 16:2680-2680
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4054f016e8b81c45ba09029486decec2
https://doi.org/10.1002/cbic.201500638
https://doi.org/10.1002/cbic.201500638