Výsledky vyhledávání - "Juthika N. Menon"

A hypothesis for the existence of two types of tuberculosis, reflecting two distinct types of immune failure to control the pathogen, based upon prevalence of mycobacterium-specific IgG subclasses

Autor: V. H. Hoeppner, A. Judd, Peter A. Bretscher, Carl Power, Juthika N. Menon

Publikováno v: Scandinavian journal of immunology. 87(6)

Most people infected by Mycobacterium tuberculosis, about 90%, contain the pathogen and are healthy. Most investigators have concluded that pathogen-specific Th1 cells contribute to protection. Pulmonary tuberculosis, the most prevalent form of disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e936013b7a2aa531e373d3a4d1e3a6
https://pubmed.ncbi.nlm.nih.gov/29607526

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Vaccination against and treatment of tuberculosis, the leishmaniases and AIDS: perspectives from basic immunology and immunity to chronic intracellular infections

Autor: Juthika N. Menon, Jude E. Uzonna, Guojian Wei, P A Bretsche, Nahed Ismail, C A Power

Publikováno v: Cellular and Molecular Life Sciences CMLS. 58:1879-1896

The occurrence of infectious disease represents a failure of the immune system, a failure that must be prevented by effective vaccination or remedied by treatment. Vaccination against acute diseases such as smallpox and polio are very effective, due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dac56ffb3269a3d4cca9c6db1728a90
https://doi.org/10.1007/pl00000824

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Distinct immunity in patients with visceral leishmaniasis from that in subclinically infected and drug-cured people: implications for the mechanism underlying drug cure

Autor: Joseph Olobo, Petrus A. Kager, Peter A. Bretscher, Juthika N. Menon, Asrat Hailu, Lashitew Gedamu, Nega Berhe, Thomas Hassard

Publikováno v: Journal of infectious diseases, 184(1), 112-115. Oxford University Press
The Journal of Infectious Diseases, 184(1), 112-115. Oxford University Press

2,b Significant levels of IgG3 and IgG4 and high levels of IgG1 leishmania-specific antibody differentiated the immune states in 10 patients with visceral leishmaniasis from those of vir- tually all 20 drug-cured and 18 subclinically infected subject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbaa92c2727b50f0c6bd559707aca10
https://doi.org/10.1086/320994

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A Case for a Neonatal, Low-Dose BCG Vaccination Trial

Autor: Carl Power, Jude E. Uzonna, Guojian Wei, Peter A. Bretscher, Juthika N. Menon

Publikováno v: Scandinavian Journal of Infectious Diseases. 33:253-257

The rational design of a successful vaccination strategy against tuberculosis requires certain kinds of information and must take account of several considerations: (i) the nature of the immune response that protects the large majority of individuals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4987899bb500cc198bec79c0f6006bd
https://doi.org/10.1080/003655401300077207

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Detection of Mycobacterium-specific interferon-gamma- producing human T lymphocytes by flow cytometryNote

Autor: Peter A. G. Tilley, Juthika N. Menon

Publikováno v: APMIS. 108:57-66

Flow cytometry has proven to be a useful tool for the investigation of cytokine synthesis by selected cell subpopulations. While most reports have used mitogen stimulation or long-term cultures with antigen, we describe here a novel method to allow t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740377ce581f316531bc0bf39ff6979c
https://doi.org/10.1034/j.1600-0463.2000.d01-6.x

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Parasite dose determines the Th1/Th2 nature of the response toLeishmania major independently of infection route and strain of host or parasite

Autor: Juthika N. Menon, Peter A. Bretscher

Publikováno v: European Journal of Immunology. 28:4020-4028

Leishmania major causes cutaneous leishmaniasis in mice and man. Infection of mice with relatively low or high numbers of parasites leads respectively to parasite containment, associated with a Th1, cell-mediated response, or progressive disease, ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42e68e4fac7ec51ac198094513ef17dd
https://doi.org/10.1002/(sici)1521-4141(199812)28:12<4020::aid-immu4020>3.0.co

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Establishment of Stable, Cell-Mediated Immunity that Makes 'Susceptible' Mice Resistant toLeishmania major

Autor: Peter A. Bretscher, Juthika N. Menon, Helle Bielefeldt-Ohmann, Guojian Wei

Publikováno v: Science. 257:539-542

Cell-mediated, but not antibody-mediated, immune responses protect humans against certain pathogens that produce chronic diseases such as leishmaniasis. Effective vaccination against such pathogens must therefore produce an immunological "imprint" so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd160570ef2a054326935c379123d30
https://doi.org/10.1126/science.1636090

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Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge

Autor: Juthika N. Menon, Peter A. Bretscher

Publikováno v: European journal of immunology. 26(1)

BALB/c mice are susceptible to a high-dose infection of the protozoan Leishmania major, which induces a parasite-specific antibody, Th2-like response, exclusive of a significant and protective cell-mediated Th1 component. We have shown, in contrast,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8d5fa9cb98b8de6a0fbea707325240
https://pubmed.ncbi.nlm.nih.gov/8566074

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