Výsledky vyhledávání - "Justyna W. Adamiak"

Akademický článek

Acinetobacter baumannii Survival under Infection-Associated Stresses Depends on the Expression of Resistance–Nodulation–Division and Major Facilitator Superfamily Efflux Pumps

Autor: Inga V. Leus, Marcela Olvera, Justyna W. Adamiak, Lauren L. Nguyen, Helen I. Zgurskaya

Publikováno v: Antibiotics, Vol 13, Iss 1, p 7 (2023)

Multidrug efflux transporters are major contributors to the antibiotic resistance of Acinetobacter baumannii in clinical settings. Previous studies showed that these transporters are tightly integrated into the physiology of A. baumannii and have div

Externí odkaz: https://doaj.org/article/06414b1471d249febb4f7b09e7452ea3

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Making sense of drug-efflux transporters in the physiological environment

Autor: Helen I Zgurskaya, Justyna W Adamiak, Inga V Leus

Publikováno v: Current opinion in microbiology. 69

Bacterial drug-efflux transporters act synergistically with diffusion barriers of cellular membranes and other resistance mechanisms to protect cells from antibiotics and toxic metabolites. Their critical roles in clinical antibiotic and multidrug re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabf1509cb1dfbfcd639b5bac3fcd658
https://pubmed.ncbi.nlm.nih.gov/35882103

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Defining new chemical space for drug penetration into Gram-negative bacteria

Autor: Vincent Bonifay, Shibin Zhao, Helen I. Zgurskaya, Jitender Mehla, Justyna W. Adamiak, Derek S. Tan

Publikováno v: Nat Chem Biol

We live in the era of antibiotic resistance, and this problem will progressively worsen if no new solutions emerge. In particular, Gram-negative pathogens present both biological and chemical challenges that hinder the discovery of new antibacterial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da71679955acbb81263f47257018522c
https://doi.org/10.1038/s41589-020-00674-6

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Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii

Autor: Inga V. Leus, Robert K. Ernst, Richard D Smith, Helen I. Zgurskaya, Lauren Smith, Sophie Richardson, Justyna W. Adamiak, Anhthu Trinh

Publikováno v: Molecular Microbiology. 114:1049-1065

Multidrug resistant (MDR) strains of Acinetobacter baumannii present a serious clinical challenge. The development of antibiotic resistance in this species is enabled by efflux pumps of the Resistance-Nodulation-Division (RND) superfamily of proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9a7cf24cfd76317b97d2e13dab99d7
https://doi.org/10.1111/mmi.14594

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