Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Justyna Sosna"'
Autor:
Justyna Sosna, Stephan Philipp, Ricardo Albay, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M. LaFerla, Charles G. Glabe
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-11 (2018)
Abstract Background Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer’s disease (AD).
Externí odkaz:
https://doaj.org/article/8db6198de3d844b4b96a4f34ba01cb0b
Autor:
Mady Elbahri, Ramzy Abdelaziz, Duygu Disci-Zayed, Shahin Homaeigohar, Justyna Sosna, Dieter Adam, Lorenz Kienle, Torben Dankwort, Moheb Abdelaziz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Water can function as a sustainable reactor for the synthesis of size-controlled, functional nanoparticles. Here, the authors introduce an underwater Leidenfrost synthesis that reproduces the dynamic chemistry of the deep ocean, in which anticancer t
Externí odkaz:
https://doaj.org/article/fe020df06a0343b0bde5b6a479c8304c
Autor:
Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, Stephan Philipp, Justyna Sosna, Charles G Glabe, Tamir Gonen, David S Eisenberg
Publikováno v:
eLife, Vol 8 (2019)
Alzheimer’s disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles wh
Externí odkaz:
https://doaj.org/article/b2be6583aeff446ab32b99c277fc5857
Autor:
Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzold
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214847 (2019)
Due to their ability to preferentially induce cell death in tumor cells, while sparing healthy cells, TNF-related apoptosis-inducing ligand (TRAIL) and agonistic anti-TRAIL-R1 or anti-TRAIL-R2-specific antibodies are under clinical investigations for
Externí odkaz:
https://doaj.org/article/b399ac7566e0450e9157f35b7a9e1750
Autor:
Maciej Giefing, Supandi Winoto-Morbach, Justyna Sosna, Claudia Döring, Wolfram Klapper, Ralf Küppers, Sebastian Böttcher, Dieter Adam, Reiner Siebert, Stefan Schütze
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84928 (2013)
The membrane bound NADPH oxidase involved in the synthesis of reactive oxygen species (ROS) is a multi-protein enzyme encoded by CYBA, CYBB, NCF1, NCF2 and NCF4 genes. Growing evidence suggests a role of ROS in the modulation of signaling pathways of
Externí odkaz:
https://doaj.org/article/89bd4ba2ef5c4d85907788bf1b227ab1
Autor:
Philip L. Felgner, Rie Nakajima, Justyna Sosna, Charles G. Glabe, Ibtisam Baghallab, Taha A. Kumosani, Jorge Mauricio Reyes-Ruiz, Luki Goldschmidt, Phuong Nguyen Mai Ho
Publikováno v:
The Journal of Biological Chemistry
Antibodies against Aß amyloid are indispensable research tools and potential therapeutics for Alzheimer's disease. They display several unusual properties, such as specificity for aggregated forms of the peptide, the ability to distinguish polymorph
Author response: Structure-based inhibitors of amyloid beta core suggest a common interface with tau
Autor:
Stephan Philipp, Sarah Griner, David Eisenberg, Duilio Cascio, Jose A. Rodriguez, Shruti Sahay, Kevin A. Murray, Tamir Gonen, Paul M. Seidler, Justyna Sosna, Jeannette Bowler, Charles G. Glabe, Michael R. Sawaya, Tianxiao Peter Yang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f527b40639f1befa3978d36938b4a65
https://doi.org/10.7554/elife.46924.036
https://doi.org/10.7554/elife.46924.036
Autor:
Dieter Adam, Ufuk Mert, Sascha Rahn, Anna Trauzold, Anna Willms, Hella Schittek, Justyna Sosna
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214847 (2019)
PLoS ONE
PLoS ONE
Due to their ability to preferentially induce cell death in tumor cells, while sparing healthy cells, TNF-related apoptosis-inducing ligand (TRAIL) and agonistic anti-TRAIL-R1 or anti-TRAIL-R2-specific antibodies are under clinical investigations for
Autor:
Elgar Susanne Quabius, Dieter Adam, Sebastian Zeissig, Stefan Schütze, Jaydeep Bhat, Ole Ammerpohl, Jürgen Fritsch, Dieter Kabelitz, Justyna Sosna
Publikováno v:
Oncotarget
// Jaydeep Bhat 1,** , Justyna Sosna 1,5,* , Jurgen Fritsch 1,* , Elgar Susanne Quabius 1,2,* , Stefan Schutze 1 , Sebastian Zeissig 3,6,7 , Ole Ammerpohl 4 , Dieter Adam 1 and Dieter Kabelitz 1 1 Institute of Immunology, Christian-Albrechts-Universi
Autor:
Ricardo Albay, Frank M. LaFerla, Charles G. Glabe, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Justyna Sosna, Stephan Philipp
Publikováno v:
Molecular Neurodegeneration
Sosna, J; Philipp, S; III, AR; Reyes-Ruiz, JM; Baglietto-Vargas, D; LaFerla, FM; et al.(2018). Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. MOLECULAR NEURODEGENERATION, 13. doi: 10.1186/s13024-018-0244-x. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4vj8b7rz
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-11 (2018)
Sosna, J; Philipp, S; III, AR; Reyes-Ruiz, JM; Baglietto-Vargas, D; LaFerla, FM; et al.(2018). Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. MOLECULAR NEURODEGENERATION, 13. doi: 10.1186/s13024-018-0244-x. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4vj8b7rz
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-11 (2018)
Background Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer’s disease (AD). Microglia